Glucose-6-phosphate dehydrogenase deficiency with recurrent infections: case report

Rosa-Borges, Abertina; Sampaio, Márcia G.; Condino‐Neto, Antônio; Barreto, Orlando C.o.; Nudelman, Victor; Carneiro-Sampaio, Magda; Nogueira, Susie Andries; Abreu, Thalita; Rehder, Jussara; Costa‐Carvalho, Beatriz Tavares

doi:10.2223/jped.243

Cited by 6 publications

(8 citation statements)

References 7 publications

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“…In Brazil, G6PDd was suggested to contribute to haemolysis in patients with the viscerocutaneous form of loxoscelism, a condition produced by the bite of the recluse spiders of genus Loxosceles [ 118 ]. In Brazil, there have been reports of recurrent infections in children diagnosed with G6PDd [ 119 , 120 ]. In contrast, increased rates of urinary tract infections and neonatal jaundice were not substantiated among pregnant women from Puerto Rico, Dominican Republic, Mexico and other Caribbean areas living in the United States.…”

Section: Resultsmentioning

confidence: 99%

Clinical complications of G6PD deficiency in Latin American and Caribbean populations: systematic review and implications for malaria elimination programmes

Monteiro

Franca

Queiroz

et al. 2014

Malar J

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BackgroundAlthough G6PDd individuals are generally asymptomatic throughout their life, the clinical burden of this genetic condition includes a range of haematological conditions, including acute haemolytic anaemia (AHA), neonatal jaundice (NNJ) and chronic non-sphaerocytic anaemia (CNSA). In Latin America (LA), the huge knowledge gap regarding G6PDd is related to the scarce understanding of the burden of clinical manifestation underlying G6PDd carriage. The aim of this work was to study the clinical significance of G6PDd in LA and the Caribbean region through a systematic review.MethodsA systematic search of the published literature was undertaken in August 2013. Bibliographies of manuscripts were also searched and additional references were identified. Only original research was included. All study designs were included, as long as any clinical information was present. Studies were eligible for inclusion if they reported clinical information from populations living in LA or Caribbean countries or about migrants from these countries living in countries outside this continent.ResultsThe Medline search generated 487 papers, and the LILACS search identified 140 papers. After applying the inclusion criteria, 100 original papers with any clinical information on G6PDd in LA were retrieved. Additionally, 16 articles were included after reading the references from these papers. These 116 articles reported data from 18 LA and Caribbean countries. The major clinical manifestations reported from LA countries were those related to AHA, namely drug-induced haemolysis. Most of the published works regarding drug-induced haemolysis in LA referred to haemolytic crises in P. vivax malaria patients during the course of the treatment with primaquine (PQ). Favism, infection-induced haemolysis, NNJ and CNSA appear to play only a minor public health role in this continent.ConclusionHaemolysis in patients using PQ seems to be the major clinical manifestation of G6PDd in LA and contributes to the morbidity of P. vivax infection in this continent, although the low number of reported cases, which could be linked to under-reporting of complications. These results support the need for better strategies to diagnose and manage G6PDd in malaria field conditions. Additionally, Malaria Control Programmes in LA should not overlook this condition in their national guidelines.

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Section: Resultsmentioning

confidence: 99%

Clinical complications of G6PD deficiency in Latin American and Caribbean populations: systematic review and implications for malaria elimination programmes

Monteiro

Franca

Queiroz

et al. 2014

Malar J

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“…One of the primary mechanisms of host immune responses in combating C. violaceum infection is by antimicrobial activities of neutrophils via expression of superoxide dismutase enzyme and the release of reactive oxygen species (ROS) (14). G6PD is essential in maintaining redox equilibrium of cellular NADPH that results in the production of ROS, including hydrogen peroxide (H 2 O 2 ), for killing pathogens (14). Microorganisms also produce H 2 O 2 from their metabolic processes, which the host cells can utilize to fight against infection.…”

Section: Discussionmentioning

confidence: 99%

The Brief Case: Recurrent Chromobacterium violaceum Bloodstream Infection in a Glucose-6-Phosphate Dehydrogenase (G6PD)-Deficient Patient with a Severe Neutrophil Defect

et al. 2020

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“…Importantly, this pathway is a key component of innate immunity and is modulated by systemic inflammation. For example, it has been shown that changes in the oxidative burst capacity are associated with various autoimmune diseases such as multiple sclerosis, arthritis, and recurrent infections 10,11 . Currently there are no high throughput quantitative assays available to measure the oxidative burst in clinical samples.…”

Section: Introductionmentioning

confidence: 99%

Bioenergetics and the Oxidative Burst: Protocols for the Isolation and Evaluation of Human Leukocytes and Platelets

Kramer

Chacko

Ravi

et al. 2014

JoVE

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Mitochondrial dysfunction is known to play a significant role in a number of pathological conditions such as atherosclerosis, diabetes, septic shock, and neurodegenerative diseases but assessing changes in bioenergetic function in patients is challenging. Although diseases such as diabetes or atherosclerosis present clinically with specific organ impairment, the systemic components of the pathology, such as hyperglycemia or inflammation, can alter bioenergetic function in circulating leukocytes or platelets. This concept has been recognized for some time but its widespread application has been constrained by the large number of primary cells needed for bioenergetic analysis. This technical limitation has been overcome by combining the specificity of the magnetic bead isolation techniques, cell adhesion techniques, which allow cells to be attached without activation to microplates, and the sensitivity of new technologies designed for high throughput microplate respirometry. An example of this equipment is the extracellular flux analyzer. Such instrumentation typically uses oxygen and pH sensitive probes to measure rates of change in these parameters in adherent cells, which can then be related to metabolism. Here we detail the methods for the isolation and plating of monocytes, lymphocytes, neutrophils and platelets, without activation, from human blood and the analysis of mitochondrial bioenergetic function in these cells. In addition, we demonstrate how the oxidative burst in monocytes and neutrophils can also be measured in the same samples. Since these methods use only 8-20 ml human blood they have potential for monitoring reactive oxygen species generation and bioenergetics in a clinical setting.

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Glucose-6-phosphate dehydrogenase deficiency with recurrent infections: case report

Cited by 6 publications

References 7 publications

Clinical complications of G6PD deficiency in Latin American and Caribbean populations: systematic review and implications for malaria elimination programmes

Clinical complications of G6PD deficiency in Latin American and Caribbean populations: systematic review and implications for malaria elimination programmes

The Brief Case: Recurrent Chromobacterium violaceum Bloodstream Infection in a Glucose-6-Phosphate Dehydrogenase (G6PD)-Deficient Patient with a Severe Neutrophil Defect

Bioenergetics and the Oxidative Burst: Protocols for the Isolation and Evaluation of Human Leukocytes and Platelets

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