1960
DOI: 10.1210/endo-66-2-280
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GLUCOSE AND ACETATE METABOLISM AND LIPOGENESIS IN MAMMARY GLANDS OF HYPOPHYSECTOMIZED RATS IN WHICH LACTATION WAS HORMONALLY INDUCED1

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Cited by 41 publications
(34 citation statements)
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“…The concentration of prolactin in the plasma of these rats was not significantly different from control rats. The requirement for prolactin and corticosteroids in the lactogenic complex of rats has been demonstrated previously in hypophysectomized animals (Bintarningshi et al 1958;Lyons et al 1958;Cowie and Lyons 1959;Abraham et al 1960). However, Kuhn (1969) has drawn attention to the care required in the interpretation of this type of experiment since lactogenesis can occur in hypophysectomized pregnant rats (Selye et al 1933;Yokoyama et al 1969) unless the foetuses and placentae are also removed Yokoyama et al 1969).…”
Section: Ovariectomized Ratsmentioning
confidence: 89%
“…The concentration of prolactin in the plasma of these rats was not significantly different from control rats. The requirement for prolactin and corticosteroids in the lactogenic complex of rats has been demonstrated previously in hypophysectomized animals (Bintarningshi et al 1958;Lyons et al 1958;Cowie and Lyons 1959;Abraham et al 1960). However, Kuhn (1969) has drawn attention to the care required in the interpretation of this type of experiment since lactogenesis can occur in hypophysectomized pregnant rats (Selye et al 1933;Yokoyama et al 1969) unless the foetuses and placentae are also removed Yokoyama et al 1969).…”
Section: Ovariectomized Ratsmentioning
confidence: 89%
“…Thus a decrease in the rate of NADPH utilization for lipogenesis will result in inhibition of the pentose phosphate pathway activity. Flux through the glycolytic and pentose phosphate pathways is closely 'coupled' in mammary gland and other lipogenic tissues, but the mechanism which brings this about is not clear [29,30,41]. The primary rate-limiting step in lactose synthesis appears to be galactosyltransferase (EC 2.4.1.22) [42].…”
Section: Potential Regulatory Enzymes Of Glucose Metabolismmentioning
confidence: 99%
“…The lactating mammary gland of the rat is considered to be an insulin sensitive tissue [41,54], although as yet the precise sites where insulin may act have not been elucidated. Glucose oxidation and its incorporation into lipid are decreased in mammary gland preparations (slices or cells) from lactating rats made insulin deficient with alloxan (2-3 days) [55,56] or anti-insulin serum (1 h) [55] and this impairment in glucose metabolism can be reversed by addition of insulin in vitro.…”
Section: Effects Of Short-term Insulin Deficiencymentioning
confidence: 99%
See 1 more Smart Citation
“…The activities of two of the enzymes of this pathway, glucose-6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase, are higher during lactation than during pregnancy in several species [ 1, . In viva studies have indicated an involvement of prolactin in this response [7,8].…”
Section: Introductionmentioning
confidence: 99%