Glucose and insulin levels in young subjects with different maternal histories of hypertension: The Hypertension in Pregnancy Offspring Study

Himmelmann, A; Himmelmann, Kate; Svensson, Anders; Hansson, Lennart

doi:10.1046/j.1365-2796.1997.66890000.x

Cited by 13 publications

(4 citation statements)

References 19 publications

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“…Thus in total, 25 publications were included in this systematic review. 9,10,18–40 These 25 publications originated from 16 population based studies. Eleven studies had one publication and five studies had multiple publications.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Hypertensive disorders of pregnancy and cardiometabolic outcomes in childhood: A systematic review

Jansen

Pluymen

Dalmeijer

et al. 2019

European Journal of Preventive Cardiology

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Background Hypertensive disorders of pregnancy (HDPs) are among the leading causes of maternal and perinatal morbidity and mortality worldwide and have been suggested to increase long-term cardiovascular disease risk in the offspring. Objective The objective of this study was to investigate whether HDPs are associated with cardiometabolic markers in childhood. Search strategy PubMed, The Cochrane Library and reference lists of included studies up to January 2019. Selection criteria Studies comparing cardiometabolic markers in 2–18-year-old children of mothers with HDP in utero, to children of mothers without HDP. Data collection and analysis Sixteen studies reported in 25 publications were included in this systematic review, of which three were considered as having high risk of bias. Thus 13 studies were included in the evidence synthesis: respectively two and eight reported pregnancy induced hypertension and preeclampsia, and three studies reported on both HDPs. Main results Most studies ( n = 4/5) found a higher blood pressure in children exposed to pregnancy induced hypertension. Most studies ( n = 7/10) found no statistically significantly higher blood pressure in children exposed to preeclampsia. No association was found between exposure to HDP and levels of cholesterol, triglycerides or glucose ( n = 5/5). No studies investigated an association with (carotid) intima-media thickness, glycated haemoglobin or diabetes mellitus type 2. Conclusions Most studies showed that exposure to pregnancy induced hypertension is associated with a higher offspring blood pressure. There is no convincing evidence for an association between exposure to preeclampsia and blood pressure in childhood. Based on current evidence, exposure to HDP is not associated with blood levels of cholesterol, triglycerides and glucose in childhood.

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Section: Resultsmentioning

confidence: 99%

“…Based on our predefined criteria, we identified three studies (one with preeclampsia and PIH, one with only PIH and one with only preeclampsia as the determinant) with a high risk of selection and information bias: the publications from the Hypertension in Pregnancy Offspring Study 9,21–23 and the studies by Lazdam et al. 27 and Hiller et al.…”

Section: Resultsmentioning

confidence: 99%

Hypertensive disorders of pregnancy and cardiometabolic outcomes in childhood: A systematic review

Jansen

Pluymen

Dalmeijer

et al. 2019

European Journal of Preventive Cardiology

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“…Several studies describe an increased risk of obesity, diabetes mellitus and hypertension in the offspring. [25][26][27][28][29] The risk of thromboembolism is not surprisingly increased in obese preg-nant women. Edwards.…”

Section: Obesity In Pregnancymentioning

confidence: 99%

Obesity and Antiphospholipid Syndrome: A Particular Challenge in Pregnancy

Mayer-Pickel

2015

Obes Res Open J

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“…This is especially true for the offspring of women who experienced gestational diabetes during the pregnancy [63]. In the Hypertension in Pregnancy Offspring Study, Himmelmann et al [66] reported that neonates born to women who were hypertensive during pregnancy appear to have a propensity to impaired glucose tolerance in later childhood [66]. Taittonen et al [67] have also reported an increased risk of hypertension in the children of women who are hypertensive during pregnancy.…”

Section: Perinatal Outcomesmentioning

confidence: 99%