Glucose and magnetic-responsive approach toward in situ nitric oxide bubbles controlled generation for hyperglycemia theranostics

Yang, Fang; Li, Mingxi; Liu, Yang; Wang, Tuan‐Tuan; Feng, Zhenqiang; Cui, Huating; Gu, Ning

doi:10.1016/j.jconrel.2016.03.002

Cited by 41 publications

(29 citation statements)

References 50 publications

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“…All reagents were purchased from Sigma–Aldrich (United States). L-arg in P-selectin-modified microspheres was prepared by double emulsion, following the procedure described in a previous study [ 10 , 11 ]. Poly(D,L-lactide) (PLA, 0.50 g) was dissolved in a methylene chloride solution (10.00 ml) at 25°C.…”

Section: Methodsmentioning

confidence: 99%

Novel microspheres reduce the formation of deep venous thrombosis and repair the vascular wall in a rat model

Dai

et al. 2017

Blood Coagulation &Amp; Fibrinolysis

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L-Arginine (L-arg), widely known as a substrate for endogenous nitric oxide synthesis, can improve endothelial function associated with the vasculature, inhibit platelet aggregation, and alter the activity of vascular smooth muscle cells. P-selectin is a membrane component of the platelet alpha-granule and the endothelial cell-specific Wiebel–Palade body that plays a central role in mediating interactions between platelets and both leukocytes and the endothelium. The experiment was designed to evaluate the effect of novel microspheres with L-arg targeting P-selectin on the formation of deep vein thrombosis and repair of vascular wall in a rat model. Thrombosis of the inferior vena cava was induced by applying a piece of filter paper (5 mm × 10 mm) saturated with 10% FeCl3 solution for 5 min. Targeted microspheres with L-arg, targeted microspheres with water, and saline were injected into the tail veins of the rats after 30 min of applying the filter paper saturated with 10% FeCl3 solution. The dry weight and length of the thrombus isolated from the inferior vena cava were significantly decreased in the group with L-arg in microsphere after 24 h. No significant differences in prothrombin time, activated partial thromboplastin time, thrombin time, and fibrinogen among the groups were indicated. Images revealed that apoptosis in the vascular wall was less in the group injected with targeted microspheres with L-arg than in the other two groups at 1 and 8 d postsurgery. Meanwhile, cell proliferation was considerably excessive in the group injected with L-arg wrapped in targeted microspheres. Therefore, these novel microspheres could decrease the formation of thrombus in the early stages and in the subsequent periods of thrombosis. The microspheres can also enhance the vitality of impaired endothelial cells and reduce cell apoptosis.

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Section: Methodsmentioning

confidence: 99%

Novel microspheres reduce the formation of deep venous thrombosis and repair the vascular wall in a rat model

Dai

et al. 2017

Blood Coagulation &Amp; Fibrinolysis

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“…As shown in Figure 11 , once the arginine contacts with H 2 O 2 , NO gas can be continuously generated in the microcontainers. The microcontainers can thus be viewed as smart “microreactors” for synthesis of the interior NO gas 73 , 173 for US imaging and NO agents related disease therapy.…”

Section: Smart Nanoscale Ddsmentioning

confidence: 99%

The Smart Drug Delivery System and Its Clinical Potential

Liu¹,

Yang²,

Xiong³

et al. 2016

Theranostics

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With the unprecedented progresses of biomedical nanotechnology during the past few decades, conventional drug delivery systems (DDSs) have been involved into smart DDSs with stimuli-responsive characteristics. Benefiting from the response to specific internal or external triggers, those well-defined nanoplatforms can increase the drug targeting efficacy, in the meantime, reduce side effects/toxicities of payloads, which are key factors for improving patient compliance. In academic field, variety of smart DDSs have been abundantly demonstrated for various intriguing systems, such as stimuli-responsive polymeric nanoparticles, liposomes, metals/metal oxides, and exosomes. However, these nanoplatforms are lack of standardized manufacturing method, toxicity assessment experience, and clear relevance between the pre-clinical and clinical studies, resulting in the huge difficulties to obtain regulatory and ethics approval. Therefore, such relatively complex stimulus-sensitive nano-DDSs are not currently approved for clinical use. In this review, we highlight the recent advances of smart nanoplatforms for targeting drug delivery. Furthermore, the clinical translation obstacles faced by these smart nanoplatforms have been reviewed and discussed. We also present the future directions and perspectives of stimuli-sensitive DDS in clinical applications.

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“…Studies in diabetic patients show that MVs can affect vascular endothelial function. When two consecutive fat-rich mixed meals were given to T2DM patients, the results showed that impaired endothelium-dependent vasodilatation is associated with increased levels of circulating endothelial-derived MVs and platelet-derived MVs [68] . An increased level of endothelial-derived MVs is positively correlated with the impairment of coronary endothelial function in patients with T2DM [69] .…”

Section: Role Of Mvs In Endothelial Dysfunction and Vascular Inflammamentioning

confidence: 99%

Pathogenic roles of microvesicles in diabetic retinopathy

2017

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Diabetic retinopathy (DR) is a common complication of diabetes and has been recognized as the leading cause of blindness in adults. Several interrelated molecular pathways are involved in the development of DR. Microvesicles (MVs) are cell membrane vesicles, which carry many biologic molecules, such as mRNAs, microRNAs, transcription factors, membrane lipids, membrane receptors, and other proteins. They may be involved in intercellular communication that can promote inflammation, angiogenesis, and coagulation. Recent studies have indicated that changes in the number and composition of MVs may reflect the pathologic conditions of DR. At present, MVs are well recognized as being involved in the pathophysiological conditions of tumors and cardio-metabolic diseases. However, the roles of MVs in DR have yet to be investigated. In this review, we provide an overview of DR-induced microvascular injury that is caused by MVs derived from endothelial and circulating cells, and discuss the possible mechanisms by which MVs can lead to endothelial dysfunction, coagulation and inflammation. In addition, the protective effects of preconditioned MVs and stem cell-derived MVs are also described . Understanding the involvement of MVs in the pathophysiological conditions of DR may provide insight into the disease mechanisms and may suggest novel therapeutic strategies for DR in the future.

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Glucose and magnetic-responsive approach toward in situ nitric oxide bubbles controlled generation for hyperglycemia theranostics

Cited by 41 publications

References 50 publications

Novel microspheres reduce the formation of deep venous thrombosis and repair the vascular wall in a rat model

Novel microspheres reduce the formation of deep venous thrombosis and repair the vascular wall in a rat model

The Smart Drug Delivery System and Its Clinical Potential

Pathogenic roles of microvesicles in diabetic retinopathy

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