Glucose biosensors based on a gold nanodendrite modified screen-printed electrode

Liu, Hsi-Chien; Tsai, Chung-Che; Wang, Gou‐Jen

doi:10.1088/0957-4484/24/21/215101

Cited by 21 publications

(16 citation statements)

References 20 publications

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“…The pulSED treatment formed the smallest surface features (26.31 ± 1.3 nm) and consisted of dendritic fractal structures as small as 5 nm. Similar Romanesco-like morphologies have been developed with other metals, including gold, 52,53 copper, 54 zinc oxide, 55 cadmium sulfide, 56 and indium tin oxide. 54 Nanoplatinum formed by PED (Fig.…”

Section: Comparison Of Various Electrodeposition Methodssupporting

confidence: 53%

pulSED: pulsed sonoelectrodeposition of fractal nanoplatinum for enhancing amperometric biosensor performance

Taguchi

Schwalb

Rong

et al. 2016

Analyst

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For the first time, we combine pulsed electrodeposition with out-of-phase pulsed sonication for controlled synthesis of fractal nanoplatinum structures as the transducer layer in electrochemical sensing. We develop and test this technique, called bimodal pulsed sonoelectrodeposition (pulSED), as a simple approach for creating highly conductive transducer nanometals for use in sensing and biosensing. We first compared the efficiency of pulSED nanoplatinum to other pulsed electrodeposition techniques, and then explored the effect of duty cycle and plating time on electroactive surface area and nanoparticle size/morphology. The developed pulSED nanoplatinum displayed fractal features with a relatively homogenous size distribution (26.31 ± 1.3 nm) and extremely high electroactive surface (0.28 ± 0.04 cm(2)) relative to other electroplating techniques (up to one order of magnitude higher). A high duty cycle (900 mHz) promotes formation of stable nanostructures (including fractal nanostructures) and reduces amorphous structure formation due to bubble cavitation and enhanced mass transport of metal ions to the electrode surface. To demonstrate the applicability of the pulSED technique, non-enzymatic and enzymatic sensors were developed for measuring hydrogen peroxide and glucose. The sensitivity for non-enzymatic peroxide sensing (3335 ± 305 μA cm(-2) mM(-1)), non-enzymatic glucose sensing (73 ± 14 μA cm(-2) mM(-1)) and enzymatic glucose biosensing (155 ± 25 μA cm(-2) mM(-1)) was higher than, or similar to, other nanomaterial-mediated amperometric sensors reported in the literature. The pulSED technique is a one pot method for tunable synthesis of nanometal structures as a transducer layer in electrochemical sensing and biosensing that requires no precursors or capping agents, and can be carried out at room temperature with inexpensive hardware.

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Section: Comparison Of Various Electrodeposition Methodssupporting

confidence: 53%

pulSED: pulsed sonoelectrodeposition of fractal nanoplatinum for enhancing amperometric biosensor performance

Taguchi

Schwalb

Rong

et al. 2016

Analyst

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“…The measurement of glucose concentration in blood is critical for diagnosis of diabetes mellitus in order to avoid some of the long-term diabetic syndromes such as the retinal and kidney damage. 24 Therefore, in order to continuously monitor glucose in diabetes there is a need for the development of improved sensors. Although enzyme based electrochemical sensors have been already reported, 25,26 however, owing to the nature of enzymes, the most common problems of enzymatic glucose sensors are high cost, poor stability and high operating potential.…”

Section: Introductionmentioning

confidence: 99%

Enhanced photocatalytic and electrochemical properties of Au nanoparticles supported TiO2 microspheres

et al. 2014

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Au/TiO 2 composites were synthesized by a two-step hydrothermal approach and their photocatalytic and electrochemical properties were investigated. It is found that Au/TiO 2 composites with a large specific surface area, stability and catalytic activity of Au nanoparticles (NPs) demonstrate enhanced photocatalytic activity compared to pure TiO 2 microspheres. Furthermore, the electrochemical properties of the Au/TiO 2 composite electrode demonstrate its ability to electrocatalyze the oxidation of hydrogen peroxide and substantially increase the response current. In addition, this modified electrode also exhibits a very rapid and sensitive response towards glucose detection at the low operating potential. The modified electrode shows a linear response from 1.0 to 15 mM with a reproducible sensitivity of 1350 mA mM À1 cm À2 within a response time of less than 6 s. The photocatalytic and electrochemical activity of Au/TiO 2 composites provides a new platform for environmental remediation and biomedical applications. All these results reveal that Au/TiO 2 composites exhibit great prospects for developing efficient non-enzymatic biosensors.

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“…The amount of charge consumed during the reduction of the oxidized gold can be obtained from the surface integration of the current versus time curves ( I – t curves) derived from the cyclic voltammograms which is a useful tool to estimate the effective sensing area of the as-prepared nanostructured electrodes ( Fig. 3 ) [ 26 ].…”

Section: Resultsmentioning

confidence: 99%

Optimized design of a nanostructured SPCE-based multipurpose biosensing platform formed by ferrocene-tethered electrochemically-deposited cauliflower-shaped gold nanoparticles

Argoubi¹,

Saadaoui²,

Aoun³

et al. 2015

Beilstein J. Nanotechnol.

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SummaryThe demand for on-site nanodevices is constantly increasing. The technology development for the design of such devices is highly regarded. In this work, we report the design of a disposable platform that is structured with cauliflower-shaped gold nanoparticles (cfAuNPs) and we show its applications in immunosensing and enzyme-based detection. The electrochemical reduction of Au(III) allows for the electrodeposition of highly dispersed cauliflower-shaped gold nanoparticles on the surface of screen-printed carbon electrodes (SPCEs). The nanostructures were functionalized using ferrocenylmethyl lipoic acid ester which allowed for the tethering of the ferrocene group to gold, which serves as an electrochemical transducer/mediator. The bioconjugation of the surface with anti-human IgG antibody (α-hIgG) or horseradish peroxidase (HRP) enzyme yields biosensors, which have been applied for the selective electrochemical detection of human IgG (hIgG) or H2O2 as model analytes, respectively. Parameters such as the number of sweeps, amount of charge generated from the oxidation of the electrodeposited gold, time of incubation and concentration of the ferrocene derivatives have been studied using cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS) and scanning electron microscopy (SEM). Selectivity and specificity tests have been also performed in the presence of potentially interfering substances to either hIgG or H2O2. Results showed that the devised immunosensor is endowed with good selectivity and specificity in the presence of several folds of competitive analytes. The enzyme-based platform showed a good catalytic activity towards H2O2 oxidation which predestined it to potential applications pertaining to enzymatic kinetics studies. The levels of hIgG in human serum and H2O2 in honey were successfully determined and served as assessment tools of the applicability of the platforms for real samples analysis.

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Glucose biosensors based on a gold nanodendrite modified screen-printed electrode

Cited by 21 publications

References 20 publications

pulSED: pulsed sonoelectrodeposition of fractal nanoplatinum for enhancing amperometric biosensor performance

pulSED: pulsed sonoelectrodeposition of fractal nanoplatinum for enhancing amperometric biosensor performance

Enhanced photocatalytic and electrochemical properties of Au nanoparticles supported TiO2 microspheres

Optimized design of a nanostructured SPCE-based multipurpose biosensing platform formed by ferrocene-tethered electrochemically-deposited cauliflower-shaped gold nanoparticles

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