Glucose Homeostatic and Pancreas Protective Potential of Tecomella Undulata Root Extract in Streptozotocin Induced Diabetic Rats .

Lal, Kanwar; Ram, Heera

doi:10.22159/ajpcr.2017.v10i6.17997

Cited by 3 publications

(2 citation statements)

References 25 publications

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“…A powder x-ray diffractometer (Model: D8 ADVANCE, Bruker AXS, Inc., Madison, WI, USA) was used to analyze the crystalline behaviour of pure PGB, pure chitosan, PM, and CBPM. The analysis of these samples was carried out using earlier reported procedure [27]. Briefly, accurately weighed samples (~1g) were mounted onto the sample holder.…”

Section: Powder X-ray Diffractometrymentioning

confidence: 99%

Intranasal Formulation and Characterization of Chitosan Microsphere for Improving in Vitro Mucoadhesion, Residence Time and Absorption Rate of Pregabalin

et al. 2023

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Objective: Chitosan-based pregabalin microsphere (CBPM) formulation was prepared to improve in vitro mucoadhesion and absorption of pregabalin via intranasal administration. Methods: The CBPM formulations were prepared using the inotropic gelation method and optimized using the Box-behnken design. The optimized CBPM formulation was physico-chemically characterized using scanning electron microscopy, thermal analysis, Fourier transform infrared spectrometry and powder x-ray diffraction. Additionally, the CBPM formulation was characterized for functional parameters such as in vitro mucoadhesion, in vitro drug release, ex vivo permeability across the sheep nasal mucosa and in vivo anticonvulsant activity in pentylenetetrazol (PTZ)-induced seizures model in mice. Results: The design-optimized CBPM exhibited a 91.45 % inclusion efficiency of pregabalin in the microspheres. The Physico-chemical analysis of the individual components and the optimized formulation confirmed the formation of CBPM. The in vitro mucoadhesion study revealed ~80% mucoadhesive of the CBPM to the sheep nasal mucosa. The in vitro dissolution profiles of CBPM was significantly higher (~97%) than that of pure pregabalin (~70%). The CBPM displayed a higher rate and extent of permeability (~90%) than pure pregabalin (~76%) across the sheep nasal mucosa. The in vivo anticonvulsant activity showed that intranasal administration of CBPM resulted in significant (P<0.01) protection against PTZ-induced convulsions in mice. Conclusion: The chitosan-based microsphere intranasal formulation could be employed as promising delivery for rapid pregabalin absorption.

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Section: Powder X-ray Diffractometrymentioning

confidence: 99%

Intranasal Formulation and Characterization of Chitosan Microsphere for Improving in Vitro Mucoadhesion, Residence Time and Absorption Rate of Pregabalin

et al. 2023

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“…The produced diffraction pattern of each sample was read and examined. The method reported earlier was followed in this study [23].…”

Section: Powder X-ray Diffractometry (Pxrd)mentioning

confidence: 99%

Enhanced Aqueous Solubility and in Vitro Dissolution of the Anti-Hyperlipidemic Agent Using Synthesized Solid Dispersion Carrier

et al. 2023

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Objective: To improve ATN's solubility, permeability, and dissolution rate of pentaerythritol-eudragit®RS100 co-processed excipients (CE) and their potential as a solid dispersion carrier (ATN-CE-SD). Methods: The ATN-CE-SD was prepared using the solvent evaporation technique. The pure ATN, physical mixture, CE carrier, and optimized ATN-CE-SD was physicochemically characterized using Scanning electron microscopy, Fourier transforms infrared spectroscopy, differential scanning calorimetry, powder x-ray diffractometry, solubility, and in vitro dissolution was used to evaluate solid dispersions. Results: Physical and chemical analysis showed that ATN-CE-SD formed via the involvement of weak intermolecular forces of attraction between CE carrier and ATN. The prepared solid dispersion showed the drug content around ~ 96.94 % w/w, indicating that the solvent evaporation method improved the encapsulation of ATN and, thus, enhanced its drug content. Compared to pure ATN (~ 0.11 mg/ml), ATN-CE-SD (1:2) significantly increased the aqueous solubility by around ~ 25-fold (~ 2.78 mg/ml), indicating solid dispersion improves the solubility of ATN. ATN-CE-SD enhanced the rate of dissolution of ATV (~ 65 %) compared to pure ATN (~ 25 %) and PM (~ 34 %). Likewise, ATN-CE-SD (1:2) improved the rate and extent of ATN (~ 60 %) across the biological membrane compared to pure ATN (~ 22 %) and PM (~ 32 %). The ATN-CE-SD (1:2) improved the dissolution efficiency by around ~ (57.31%) compared to pure ATN (~ 7.02%) and PM (~ 20.43%). According to the study, co-processed excipients could serve as a promising solid dispersion carrier and improve ATN's water solubility, permeability, and dissolution rate. Conclusion: Based on the results, it is possible to use synthetic solid dispersion carriers as alternatives to improve the low water solubility and permeability of ATN.

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DPP-4 inhibition mediated antidiabetic potential of phytoconstituents of an aqueous fruit extract of Withania coagulans (Stocks) Dunal: in-silico, in-vitro and in-vivo assessments

Kumar

Ram

Kala

et al. 2022

Journal of Biomolecular Structure and Dynamics

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Glucose Homeostatic and Pancreas Protective Potential of Tecomella Undulata Root Extract in Streptozotocin Induced Diabetic Rats .

Cited by 3 publications

References 25 publications

Intranasal Formulation and Characterization of Chitosan Microsphere for Improving in Vitro Mucoadhesion, Residence Time and Absorption Rate of Pregabalin

Intranasal Formulation and Characterization of Chitosan Microsphere for Improving in Vitro Mucoadhesion, Residence Time and Absorption Rate of Pregabalin

Enhanced Aqueous Solubility and in Vitro Dissolution of the Anti-Hyperlipidemic Agent Using Synthesized Solid Dispersion Carrier

DPP-4 inhibition mediated antidiabetic potential of phytoconstituents of an aqueous fruit extract of Withania coagulans (Stocks) Dunal: in-silico, in-vitro and in-vivo assessments

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