Glucose, Insulin and Somatostatin Infusion for the Determination of Insulin Sensitivity

Harano, Yutaka; Ohgaku, Seiji; Hidaka, Hideki; Haneda, Kentaro; Kikkawa, Ryuichi; Shigeta, Yukio; Abe, Hiroshi

doi:10.1210/jcem-45-5-1124

Cited by 151 publications

(73 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…A study [13] showed that the concentrations of soluble ICAM-1, VCAM-1, and E-selectin correlate with the degree of insulin resistance calculated from a modified insulin suppression test [25] in healthy volunteers. We did not find a correlation between the extent of insulin resistance, determined by the euglycaemic hyperinsulinaemic clamp and the concentration of plasma ICAM-1 or VCAM-1 in any group.…”

Section: Discussionmentioning

confidence: 99%

Relation between glycaemic control, hyperinsulinaemia and plasma concentrations of soluble adhesion molecules in patients with impaired glucose tolerance or Type II diabetes

et al. 2002

View full text Add to dashboard Cite

Patients with Type II (non-insulin-dependent) diabetes mellitus have an increased risk for premature atherosclerosis [1,2]. Increased concentrations of plasma adhesion molecules (AM) have been detected in patients with developing atherosclerosis [3] and in patients with Type I (insulin-dependent) diabetes mellitus [4,5] and Type II diabetes [6±9]. Moreover, increased plasma concentrations of soluble forms of some of these adhesion molecules have been suggested as markers of early atherosclerosis [10,11]. These Diabetologia (2002) with the other groups. The adhesion molecule concentrations correlate with the fasting plasma glucose (r = 0.59, p < 0.001), the 2-h OGTT plasma glucose (r = 0.70, p < 0.01), and the HbA 1 c value (r = 0.61, p < 0.05). The E-selectin but not the ICAM-1 and VCAM-1 plasma concentrations correlated with the fasting insulin concentrations (r = 0.62, p < 0.05) or the whole body glucose uptake (r = 0.59, p < 0.05) in the clamp. The hyperinsulinaemia during the euglycaemic hyperinsulinaemic clamp had no significant effect on the plasma concentrations of E-selectin, ICAM-1, and VCAM-1 in all three groups. Conclusion/interpretation. Our results suggest that increased E-selectin concentrations are related to hyperglycaemia, hyperinsulinaemia and insulin resistance, whereas increased ICAM-1 and VCAM-1 plasma concentrations in patients with Type II diabetes are rather related to hyperglycaemia than to hyperinsulinaemia or insulin resistance. [Diabetologia (2002) 45: 210±216]

show abstract

Section: Discussionmentioning

confidence: 99%

Relation between glycaemic control, hyperinsulinaemia and plasma concentrations of soluble adhesion molecules in patients with impaired glucose tolerance or Type II diabetes

et al. 2002

View full text Add to dashboard Cite

show abstract

“…A modified insulin suppression test [17,18] was carried out on all the subjects at the end of the dietary period. The study began at 8:00 am, after 12 h of fasting.…”

Section: Glucose Suppression Testmentioning

confidence: 99%

The SstI polymorphism of the apo C-III gene is associated with insulin sensitivity in young men

Pérez‐Jiménez

Gomez

et al. 2002

Diabetologia

View full text Add to dashboard Cite

Aims/hypothesis. Insulin resistance is considered to be a risk factor for diabetes and coronary heart disease and is determined by the interaction between genetic and environmental factors. The SstI polymorphism in the apolipoprotein C-III gene has been related to the presence of different features of the insulin resistance syndrome. We investigate if this mutation influences the peripheral effect of insulin in healthy young subjects (30 men and 29 women) eating a westernised diet. Methods. We investigated peripheral insulin sensitivity with the insulin suppression test after a 28-day westernised high-saturated fat diet (38% total fat and 18% saturated fat with 115 mg of cholesterol per 1000 Ju). Results. Steady state plasma glucose values were lower in S1-S1 compared with S1-S2 men (p=0.018 by ANOVA), but not in women (p=0.723). Conclusion/interpretation. There was no difference between carriers and non-carriers of the S2 allele in relation to incidence and sensitivity; although on subgroup analysis there was an effect in men but not in women. [Diabetologia (2002[Diabetologia ( ) 45:1196[Diabetologia ( -1200 Keywords High-saturated fat diet, insulin sensitivity, glucose metabolism, non-esterified fatty acids.

show abstract

“…The high levels of 24-hr UCPR in NIDDM-NO were thought to be induced by uncontrolled plasma glucose levels. Harano et al (1977) reported that reduced insulin sensitivity could not be improved with dietary therapy in his evaluating system using cyclic somatostatin to suppress the endogenous secretions of insulin, glucagon and growth hormone in adult-onset, non-obese, untreated diabetics. In the present study, ISI in NIDDM-NO, obtained according to the method of Harano et al (1977), were significantly lower than those in healthy subjects.…”

Section: Resultsmentioning

confidence: 99%

“…The insulin sensitivity test was made according to the method of Harano et al (1977). The procedure was as follows (Fig.…”

Section: Methodsmentioning

confidence: 99%

Effect of diet restriction on 24-hr urinary C-peptide excretion in non-insulin dependent non-obese diabetic subjects.

Ôshima

1985

Tohoku J. Exp. Med.

View full text Add to dashboard Cite

OSHIMA, Y. Effect of Diet Restriction on 24-hr Urinary C-Peptide Excretion in Non-Insulin Dependent Non-Obese Diabetic Subjects. Tohoku J. exp. Med., 1985, 145 (3), [329][330][331][332][333] -Changes in insulin secretory responses by diet restriction were analyzed in non-insulin dependent non-obese diabetic subjects (NIDDM-NO) as well as in healthy volunteers by determining 24-hr urinary C-peptide immunoreactivity (24-hr UCPR). Insulin sensitivity for glucose utilization was measured by using cyclic somatostatin. Overnight fasting plasma glucose concentrations decreased in NIDDM-NO ; however, 24-hr UCPR was reduced in both NIDDM-NO and healthy controls by diet restriction (25 kcal/kg) for 14 days. The level of 24-hr UCPR was higher but insulin sensitivity was lower in NIDDM-NO as compared with those in healthy controls. Therefore, diet restriction may be effective in controlling hyperglycemia and hypersecretion of insulin in NIDDM-NO, but it alone may not improve the reduced insulin sensitivity.24-hr urinary C-peptide excretion ; insulin sensitivity ; diet restriction ; non-insulin dependent non-obese diabetics A few attempts have been made to elucidate the relationship between 24-hr urinary C-peptide immunoreactivity (24-hr UCPR) and metabolic control in diabetics (Horwitz et al. 1975;Pasquali et al. 1982). However, the previous studies did not observe the changes in 24-hr UCPR after dietary therapy in non-insulin dependent, non-obese diabetics (NIDDM-NO) in comparison with those in healthy subjects. The present study clarifies the differential effects of diet restriction on insulin secretory responses in NIDDM-NO and healthy controls. SUBJECTS AND METHODSThe subjects in this study were 27 males and 13 females of recently diagnosed diabetics aged ranging from 34 to 79 years (mean=54.4 years) who did not require insulin therapy, and 4 healthy volunteers (23-42 years old). The body weight of all the subjects ranged within ±18% of the standard weight. None had liver dysfunction or infectious disease. Their creatinine clearance rates were more than 65.0 ml mm.All the patients were admitted to our hospital for dietary therapy. At first, 2100 kcal diet was given for 3 days, and then therapeutic diet (25 kcal kg) was given for 14 days.

show abstract

Glucose, Insulin and Somatostatin Infusion for the Determination of Insulin Sensitivity

Cited by 151 publications

References 0 publications

Relation between glycaemic control, hyperinsulinaemia and plasma concentrations of soluble adhesion molecules in patients with impaired glucose tolerance or Type II diabetes

Relation between glycaemic control, hyperinsulinaemia and plasma concentrations of soluble adhesion molecules in patients with impaired glucose tolerance or Type II diabetes

The SstI polymorphism of the apo C-III gene is associated with insulin sensitivity in young men

Effect of diet restriction on 24-hr urinary C-peptide excretion in non-insulin dependent non-obese diabetic subjects.

Contact Info

Product

Resources

About