Glucose kinetics in human obesity

Franckson, Jean; Malaise, W.; Arnould, Y; Rasio, E; Ooms, Henri; Balasse, Edmond; Conard, V.; Bastenie, Paul Auguste

doi:10.1007/bf00423017

Cited by 52 publications

(11 citation statements)

References 20 publications

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“…There is no significant difference between this of ideal weight. This change in plasma insulin level must be taken to infer changes in the rate of insulin secretion [27], and in accordance with the previous observations, interpreted as an increased production and requirement of insulin in obesity [60,48,41,34,24,32,49,58,52,29,4] Overweight is also associated with higherinsulinresponseto stimuli of insulin secretion such as glucagon [33], tolbutamide [52], and arginine [44] ; and high calorie intake must increase the activity of the beta cells present [11]. The higher insulin levels seen after glucose load is not the dominant characteristic of the obese, being in part due to the general relationship between the fasting and the post-stimulating insulin value.…”

Section: Insulin and Corpulencesupporting

confidence: 53%

Diabetes survey plasma insulin during 0-2h oral glucose tolerance test systematically carried out in a professional group

Rosselin¹,

Claude²,

Eschwège³

et al. 1971

Diabetologia

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Section: Insulin and Corpulencesupporting

confidence: 53%

Diabetes survey plasma insulin during 0-2h oral glucose tolerance test systematically carried out in a professional group

Rosselin¹,

Claude²,

Eschwège³

et al. 1971

Diabetologia

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“…Un r6gime de 1000 cal. par jour a dt6 institu6 pour les deux groupes et nous avons enregistr6 une perte de poids moyenne de 21.2kg pour la premigre et de 17 [2,3,6,8,9,10,16,17,24,27,32,33,35,45,55,56,61,65,74,76,79,92]. Aueh fiber die Rfickbildung einiger dieser Ver/~nderungen bei di/ttetisch bedingter Gewiehtsreduktion wurde mehrfaeh berichtet [6,7,12,29,31,32,38,39,44,45,58,59,74,76,77,78,83,87].…”

Section: Influence D'une R~duction De Poids Sur Le Mgtabolisme Des Caunclassified

Einflu� der Gewichtsreduktion auf Metabolite des Kohlenhydrat- und Fettstoffwechsels und auf das Verhalten des Seruminsulins bei Adipositas

et al. 1968

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Influence of weight reduction on carbohydrate and fat metabolism and on serum insulin response in obesitySummary. To find out which of the metabolic changes observed in obesity are reversible by a reducing diet, we examined 37 obese out-patients with a mean overweight of 71~o B~ocA. A manifest diabetes mellitus and endocrine diseases were excluded by clinical means. 20 subjects showed disturbances of carbohydrate-tolerance. Oral and i.v. glucose-tolerance tests gave normal results in 17. Both subgroups were put on a 1000 cal. mixed diet and had mean weightdosses of 21.2, vs. 17.5 kg, corresponding to 34% vs. 28% BROCA, i.e. less than half of their overweight. --The following changes were observed in the subgroup with impaired carbohydrate-tolerance: --1. Significant improvement of glucose-tolerance with beginning normalization of fasting blood sugar, 120' value after oral glucose and of the k-values for i.v. and oral glucose-tolerance tests. --2. Highly significant reduction of the elevated fasting values for free serum glycerol with normalization of the quotient: free fatty acids/glycerol in fasting serum. --3. Significant fall of the high levels for insulin-like activity and for immunologically reacting insulin. --Under identical conditions the subgroup with normal carbohydrate-tolerance showed only a moderate increase of free fatty acids 90' and 120' after glucose. In the obese group as a whole, we found a reduction of serum esterified fatty acids under low calorie diet. --The changes described under 1--3 were more pronounced with this dietary treatment than in fasting periods generally described until now, and occurred predominantly in the subgroup with impaired carbohydrate-tolerance. Our findings indicate that hyperinsulinism held responsible for obesity up to now by some authors is probably adaptire.

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“…Kinetic studies of glucose utilization in obese patients have demonstrated a reduction in the disappearance rate and uptake of glucose from the blood (1). There is now considerable evidence in support of the concept that the disordered glucose metabolism of obesity may be related to the presence of insulin resistance.…”

Section: Introductionmentioning

confidence: 99%

The effect of insulin upon glucose metabolism by adipose cells of different size

Salans¹,

Dougherty²

1971

J. Clin. Invest.

175

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A B S T R A C T Glucose metabolism and insulin sensitivity of isolated rat epididymal fat cells and of their delipidated derivatives ("ghosts") was studied as a function of cellular lipid content (fat cell size), cellular protein content, animal age, and state of nutrition in an effort to examine the relationship of adipose cell size to adipose tissue insulin sensitivity.In ad libitum-fed rats, basal rates of glucose-1-"C incorporation into C02 and triglyceride are similar over a wide range of adipose cell size. In contrast, the insulin sensitivity of intact fat cells from rats fed ad libitum is inversely related to their lipid content: the larger the cell, the less the response to insulin. This "resistance" of the enlarged adipose cell to the action of insulin was demonstrated by a reduction in the per cent rise above the basal rate as well as in the absolute rate of glucose oxidation and lipogenesis caused by insulin.The protein content of fat cells was found to be relatively constant over a wide range of fat cell size. Thus, enlarged insulin "resistant" fat cells contained the same amount of protein as smaller insulin "sensitive" cells.These relationships between insulin sensitivity and cellular lipid or protein content were true regardless of whether cells of different sizes were obtained from animals of different body weights and ages, or from different portions of the epididymal fat pads of animals of the same weight and age.Acute delipidation of intact fat cells did not appear to alter these relationships between basal glucose metabolism, insulin sensitivity, and cell size. "Ghosts" prepared from fat cells of widely different sizes metabolized glu-A preliminary report of a portion of this study has appeared in abstract form 1970 J. Clin. Res. 18: 463.

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Glucose kinetics in human obesity

Cited by 52 publications

References 20 publications

Diabetes survey plasma insulin during 0-2h oral glucose tolerance test systematically carried out in a professional group

Diabetes survey plasma insulin during 0-2h oral glucose tolerance test systematically carried out in a professional group

Einflu� der Gewichtsreduktion auf Metabolite des Kohlenhydrat- und Fettstoffwechsels und auf das Verhalten des Seruminsulins bei Adipositas

The effect of insulin upon glucose metabolism by adipose cells of different size

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