Glucose metabolism and insulin secretion in children with cyanotic congenital heart disease

Kh, Lundell; Kg, Sabel; Eriksson, Bo; Mellgren, Gösta

doi:10.1111/j.1651-2227.1997.tb14812.x

Cited by 10 publications

(4 citation statements)

References 9 publications

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“…70 It would therefore be expected that a significant percentage of the population with moderate or complex ACHD will have diabetes mellitus or abnormal glucose metabolism. Of note, with regard to glucose management, the fasting glucose level in cyanotic patients may be lower because of the high resting catecholamine state and impaired nutritional status 71 ; however, there may concomitantly be increased clearance of insulin by the lung in right-to-left shunts.…”

Section: Prevalencementioning

confidence: 99%

Congenital Heart Disease in the Older Adult

Bhatt¹,

Foster²,

Kuehl³

et al. 2015

Circulation

205

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Section: Prevalencementioning

confidence: 99%

Congenital Heart Disease in the Older Adult

Bhatt¹,

Foster²,

Kuehl³

et al. 2015

Circulation

205

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“…Hait et al 27) reported that glucose levels could be high in patients with a left-to-right shunt lesion such as ASD, VSD, and atrioventricular septal defect as well as even in cyanotic patients including those with Eisenmenger syndrome due to excessive clearance of insulin by the lungs. However, Lundell et al 28) suggested that cyanotic patients can also have lower glucose levels when fasting because of chronic increases in circulating catecholamines and poor nutrition. In our study, cyanotic patients including patients with Eisenmenger syndrome showed significantly higher glucose levels than those in the other two groups.…”

Section: Discussionmentioning

confidence: 99%

Analysis of Cardiovascular Risk Factors in Adults with Congenital Heart Disease

Moon¹,

Song²,

Huh³

et al. 2015

Korean Circ J

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Background and ObjectivesThe objective of this study was to analyze cardiovascular risk factors in adults with congenital heart disease (ACHD).Subjects and MethodsThe subjects for this study comprised 135 patients, aged 18 years and above, who visited the ACHD clinic at the Samsung Medical Center and 135 adults with a structurally normal heart who were randomly selected from the Center for Health Promotion during the same period. For the analysis, the ACHD group was further divided into an ACHD group that underwent correction by cardiac surgery and a cyanotic group.ResultsThe mean (standard diviation) age (years) of patients in the surgically corrected group was 48.4 (10.9) years, while that of patients in the cyanotic group was 43.1 (9.0) years and that of patients in the control group was 47.1 (10.3) years (p=0.042). The adjusted odds ratios (ORs) for past smoking, hypertension, diabetes mellitus, hypercholesterolemia, obesity, and metabolic syndrome were significantly higher in the surgically corrected patients than in the controls. However, the ORs for all variables excluding past smoking were significantly lower in the cyanotic group compared with the control group. After adjustment for age, gender, smoking, alcohol use, and exercise, the ORs for metabolic syndrome were 0.46 (0.35-0.57, p<0.001) and 1.48 (1.14-1.92, p=0.003) in the cyanotic and surgically corrected groups, respectively.ConclusionCardiovascular risk factors need to be considered in surgically corrected ACHD patients as well as in adults with a structurally normal heart. A further study with a long-term follow-up is needed for developing guidelines for prevention.

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“…However, WHR, HOMA-IR, serum C-peptide levels were found to be non-significant when compared to controls. This may be due to increase of catecholamine in circulation [20].…”

Section: Discussionmentioning

confidence: 99%

Comparison Between Serum Insulin Levels and Its Resistance With Biochemical, Clinical and Anthropometric Parameters in South Indian Children and Adolescents

et al. 2010

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There is a rising trend in the prevalence of insulin resistance among obese, overweight children and adolescents. The serum insulin and its correlation with biochemical, clinical and anthropometric parameters were evaluated in 185 children and adolescents (59 control, 52 obese, 49 overweight, 25 congenital heart disease) of age group 10-17 years. The levels of serum insulin were measured by ELISA. Serum insulin levels were found to be significantly increased in children who were obese, overweight and had congenital heart disease, than controls. Serum insulin levels positively correlated with BMI, WHR, and serum C-peptide, serum leptin, total cholesterol, triglycerides, LDL-cholesterol, systolic and diastolic blood pressure. Fasting glucose levels were found to be negatively correlated with serum insulin levels. HDL-cholesterol levels were non-significant among the study groups. We identified nine obese children (five girls and four boys) with the features of metabolic syndrome and 69% of obese and overweight children were identified with insulin resistance. Insulin resistance was strongly associated with metabolic syndrome and its components, especially with central obesity and hypertriglyceridemia.

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Glucose metabolism and insulin secretion in children with cyanotic congenital heart disease

Cited by 10 publications

References 9 publications

Congenital Heart Disease in the Older Adult

Congenital Heart Disease in the Older Adult

Analysis of Cardiovascular Risk Factors in Adults with Congenital Heart Disease

Comparison Between Serum Insulin Levels and Its Resistance With Biochemical, Clinical and Anthropometric Parameters in South Indian Children and Adolescents

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