2011
DOI: 10.1042/bse0510015
|View full text |Cite
|
Sign up to set email alerts
|

Glucose metabolism in Trypanosoma cruzi

Abstract: The causative agent of Chagas disease, Trypanosoma cruzi, metabolizes glucose through two major pathways: glycolysis and the pentose phosphate pathway. Glucose is taken up via one facilitated transporter and its catabolism by the glycolytic pathway leads to the excretion of reduced products, succinate and l-alanine, even in the presence of oxygen; the first six enzymes are located in a peroxisome-like organelle, the glycosome, and the lack of regulatory controls in hexokinase and phosphofructokinase results in… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
2

Citation Types

2
42
0

Year Published

2013
2013
2023
2023

Publication Types

Select...
5
1

Relationship

0
6

Authors

Journals

citations
Cited by 50 publications
(64 citation statements)
references
References 56 publications
2
42
0
Order By: Relevance
“…It is interesting to highlight that all the descriptions of the metabolic pathways of T. cruzi are in accordance to the organic acids detected in the 3rd day of culture [7]. However, the metabolic differences were not found in the literature when the parasite undergoes culture growth, and how different concentrations of benznidazole affect their metabolism is not found as well.…”
Section: Discussionmentioning
confidence: 81%
See 4 more Smart Citations
“…It is interesting to highlight that all the descriptions of the metabolic pathways of T. cruzi are in accordance to the organic acids detected in the 3rd day of culture [7]. However, the metabolic differences were not found in the literature when the parasite undergoes culture growth, and how different concentrations of benznidazole affect their metabolism is not found as well.…”
Section: Discussionmentioning
confidence: 81%
“…The detection of citrate indicates the presence of the mitochondrial metabolic pathway of energy production [7]. However, the decrease in the citrate, succinate and fumarate concentrations throughout the experimental days indicates that these pathways are being suppressed while the epimastigotes tend to undergo metacyclogenesis in the culture medium [22].…”
Section: Discussionmentioning
confidence: 99%
See 3 more Smart Citations