Glucose-sensitive self-healing hydrogel as sacrificial materials to fabricate vascularized constructs

Tseng, Ting-Chen; Hsieh, Fu-Yu; Mutlu, Hatice; Wei, Yen; Hsu, Shan‐hui

doi:10.1016/j.biomaterials.2017.04.008

Cited by 101 publications

(68 citation statements)

References 32 publications

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“…rapid erosion at highly acidic/alkaline pHs but stable at 3 > pH > 10 [42][43][44] PVA/sodium alginate containment of hazardous chemicals alginate improved the stretchability [46] GG as flocculant in water treatment [47,48] GG/glycerol -antifreeze, injectable, water stable, flexible, stretchable [49] HPG/glycerol -glycerol at < 1 wt % acts as stiffening agent & at > 1wt % as plasticizer [50] FG water-retaining agent in agriculture [51] PVA/SF sensing platforms SF boost stretchability (> 5000 %), healability, adhesivity & thermal stability [52] Functionalized polyol/B hydrogels PVA-g-PAA smart electrochemical capacitors PAA improved salt tolerance & flexibility [53] JG-g-PAAm removal of Brilliant Blue R dye from water easy regeneration of hydrogel-based adsorbent [54] PAH-g-Glu showing viscoelastic behavior at pH � 6; gradual degradation at pH > 8 [55] PEG-diacrylate/DTT as glucose-sensitive sacrificial material for fabrication of vascularized constructs one-pot polymerization and hydrogel formation via borate-catalyzed click reaction [56,57] Nanocomposite borax-based hydrogels PVA/CNC or CNF CNC or CNF boost mechanical strength and viscoelasticity [58][59][60] PVA/CNF supercapacitor Zn(II) endow excellent ionic conductivity [61] PVA/MFC MFC improve mechanical strength and viscoelasticity [62] PVA/Ag/TA/CNC strain sensor; circuit repairing agent; electronic skin, and touch screen pens.…”

Section: Sclgmentioning

confidence: 99%

Self‐healing Polyol/Borax Hydrogels: Fabrications, Properties and Applications

Seidi

Jin

Han

et al. 2020

The Chemical Record

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Self-healing polyol/borax hydrogels have found great applications in various areas; especially in sensors, flexible electronics and biomedical fields. In this review, fabrication and characteristics of various types of borax-based hydrogels are discussed. Mechanical properties and self-healing behaviors of these hydrogels are strongly affected by the types of polyol, ratio of polyol:borax, and concentration of each component. Incorporation of highly polar nanofillers (such as cellulose nanofibers) into hydrogels and fabrication of double-network structures have been employed as the promising strategies for improving the mechanical properties. Other additives have also been examined to generate nanocomposite hydrogels for a wide variety of uses; e. g. polyphenols for developing adhesives, conducting polymers, and hybrid structures based on carbon nanotubes and graphenes for electroconductivity, Ag and ZnO nanoparticles for antibacterial property, and quantum dots for fluorescence.

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Section: Sclgmentioning

confidence: 99%

Self‐healing Polyol/Borax Hydrogels: Fabrications, Properties and Applications

Seidi

Jin

Han

et al. 2020

The Chemical Record

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“…Sacrificial materials used for templating channels and networks in 3D volumes include reversibly crosslinked gelatin, carbohydrate glass, agarose, Pluronic, shear‐thinning MeHA hydrogels with GH bonds, freestanding PVA scaffolds, self‐healing glucose, and PEGDA hydrogels. [ 214,225–231 ] Carbohydrate glass (glucose, sucrose, and dextran blend) fibers demonstrate excellent versatility with a range of natural and synthetic materials and can be drawn into programmable space‐filling lattices or aligned channels with high pattern fidelity post washing. [ 229,232 ] Fabricated scaffolds can be connected to microfluidic perfusion systems that allow introduction of ECs into hollow channels and subsequent lumenization.…”

Section: Fabrication Strategies To Generate Microfluidic and Vascularmentioning

confidence: 99%

Biofabrication Strategies and Engineered In Vitro Systems for Vascular Mechanobiology

Pradhan

Banda

Farino

et al. 2020

Adv Healthcare Materials

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The vascular system is integral for maintaining organ‐specific functions and homeostasis. Dysregulation in vascular architecture and function can lead to various chronic or acute disorders. Investigation of the role of the vascular system in health and disease has been accelerated through the development of tissue‐engineered constructs and microphysiological on‐chip platforms. These in vitro systems permit studies of biochemical regulation of vascular networks and parenchymal tissue and provide mechanistic insights into the biophysical and hemodynamic forces acting in organ‐specific niches. Detailed understanding of these forces and the mechanotransductory pathways involved is necessary to develop preventative and therapeutic strategies targeting the vascular system. This review describes vascular structure and function, the role of hemodynamic forces in maintaining vascular homeostasis, and measurement approaches for cell and tissue level mechanical properties influencing vascular phenomena. State‐of‐the‐art techniques for fabricating in vitro microvascular systems, with varying degrees of biological and engineering complexity, are summarized. Finally, the role of vascular mechanobiology in organ‐specific niches and pathophysiological states, and efforts to recapitulate these events using in vitro microphysiological systems, are explored. It is hoped that this review will help readers appreciate the important, but understudied, role of vascular‐parenchymal mechanotransduction in health and disease toward developing mechanotherapeutics for treatment strategies.

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“…Tseng et al . also showed that EC migration and angiogenesis were significantly improved in the glucose‐sensitive, self‐healing hydrogel . Due to the crosstalk of ECs and neural stem cells (NSCs), the expression of genes related to angiogenesis from ECs was increased and enabled neuronal differentiation of NSCs.…”

Section: Type Of Polymers and Design Strategiesmentioning

confidence: 99%

Design of Polymeric Culture Substrates to Promote Proangiogenic Potential of Stem Cells

Kwon

Wang

Kang

et al. 2017

Macromolecular Bioscience

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Stem cells are a promising cell source for regenerative medicine due to their differentiation and self-renewal capacities. In the field of regenerative medicine and tissue engineering, a variety of biomedical technologies have been tested to improve proangiogenic activities of stem cells. However, their therapeutic effect is found to be limited in the clinic because of cell loss, senescence, and insufficient therapeutic activities. To address this type of issue, advanced techniques for biomaterial synthesis and fabrication have been approached to mimic proangiogenic microenvironment and to direct proangiogenic activities. This review highlights the types of polymers and design strategies that have been studied to promote proangiogenic activities of stem cells. In particular, scaffolds, hydrogels, and surface topographies, as well as insight into their underlying mechanisms to improve proangiogenic activities are the focuses. The strategy to promote angiogenic activities of hMSCs by controlling substrate repellency is introduced, and the future direction is proposed.

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Glucose-sensitive self-healing hydrogel as sacrificial materials to fabricate vascularized constructs

Cited by 101 publications

References 32 publications

Self‐healing Polyol/Borax Hydrogels: Fabrications, Properties and Applications

Self‐healing Polyol/Borax Hydrogels: Fabrications, Properties and Applications

Biofabrication Strategies and Engineered In Vitro Systems for Vascular Mechanobiology

Design of Polymeric Culture Substrates to Promote Proangiogenic Potential of Stem Cells

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