Glucose sensor based on a field-effect transistor with a photolithographically patterned glucose oxidase membrane

Equivalent Li.cntdot..cntdot..cntdot.O and H.cntdot..cntdot..cntdot.O electronic effects in the lithium enolate of 1,3-cyclohexanedione

“…The splitting between the two major peaks in our spectrum (Figure 1) is determined to be about 490 cm"1, which is comparable to the one for the solid sample at 5 K. 6 We believe that this corresponds to the energy of a vibrational quantum for the other totally symmetric (A,), Raman active breathing mode in the ground state,14 496 cm" . In fact, the emission spectra from 20 K film also seem to reveal the same feature, although it is not explicitly mentioned (upper spectrum of Figure 3 of ref 5).…”

“…Here again, polycrystalline solid at 5 K gives a spectrum similar to that of our room temperature sample, the only difference being the relative peak heights. 6 The recently reported emission spectrum of C70 at 77 K shows a much better resolved fine structure,7 but our room temperature solution spectrum clearly gives a rough envelope of it. It is estimated that when calibrated against the same optical density, the fluorescence intensity of C60 at the peak is about 5 times weaker than that of C70.…”

Field‐Effect transistors as transducers in biosensors for substrates of dehydrogenases

“…The source and drain regions were obtained by ion implantarion of cm-' phosphorus atoms at 100 keV e n e r p . The sensitivity of the Si02-ISFET was about 4 j mV/pH, whereas the Si,N,-ISFET showed near-Nernstian behavior with j j to 57 m\'/ pH compared to 45 to 56 mV/pH [5,6,11]. The drift (less than 1 mV/h) is comparable to values found in the literature [5,12].…”

“…Ion-sensitive field-effect transistors (ISFETs) [ 11 have found wide application in pH measurements [2-41. By combination of ISFETs with enzyme membranes enzyme fieldeffect transistors (ENFETs) [ 5,6] have been obtained measuring the pH shift caused by an enzyme-catalyzed reaction and hence imposing the enzyme's selectivity to that of the transducer. Consequently, most interests have been focused on the application of hydrolases and inherent problems with the use of ENFETs like drift of the sensor output, light sensitivity, difficulties of encapsulation, and problems of the reproducible deposition of enzyme layers [7].…”

Chemical pattern on silica surface prepared by UV irradiation of 3-mercaptopropyltriethoxy silane layer: surface characterization and fibrinogen adsorption

“…Patterned surfaces were used as multi-channel biosensors [19][20][21] and, because micron-size patterns match the size of animal cells, also as tools for studying the effects of surface chemistry on cell adhesion and subsequent cell morphogenesis [10,22,23]. The motivation for the study reported here was similar: a patterned modified silica surface was prepared by UV irradiation as a means of spatially controlling the surface density of fibrinogen, a protein implicated in platelet activation and adhesion.…”