Glucose sensors based on electrospun nanofibers: a review

Abstract

The worldwide increase in the number of people suffering from diabetes has been the driving force for the development of glucose sensors. The recent past has devised various approaches to formulate glucose sensors using various nanostructure materials. This review presents a combined survey of these various approaches, with emphasis on the current progress in the use of electrospun nanofibers and their composites. Outstanding characteristics of electrospun nanofibers, including high surface area, porosity, flexibility, cost effectiveness, and portable nature, make them a good choice for sensor applications. Particularly, their nature of possessing a high surface area makes them the right fit for large immobilization sites, resulting in increased interaction with analytes. Thus, these electrospun nanofiber-based glucose sensors present a number of advantages, including increased life time, which is greatly needed for practical applications. Taking all these facts into consideration, we have highlighted the latest significant developments in the field of glucose sensors across diverse approaches.

Electrospun Nanostructures for High Performance Chemiresistive and Optical Sensors

“…Crystal structure of the H-WO 3 NFs was confirmed by a selective area electron diffraction (SAED) pattern, which revealed crystal planes of (002), ( 112), and (022) (in the inset of Figure 9d). HRTEM and fast Fourier transform analysis identified crystalline structure of nanoneedles with the crystal planes of (200) and (020), which corresponds to the interplanar distance of 3.65 and 3.75 Å, respectively. In terms of the formation mechanism of branched nanoneedles on the surface of WO 3 NFs, the growth of the branched nanoneedles can be explained by vapor-solid reaction process.…”

“…The detection of glucose is another application which is rapidly expanding in its importance due to the increasing demand of efficient, fast and noninvasive sensors for people suffering diabetes. [200] Membranes of PS NFs functionalized with GOD and doped with a transition metal complex [iridium(III) bis(2-phenylbenzothiozolato-N,C 2 ′) acetylacetonate] rely on the quenching of the Ir-complex in presence of oxygen: [201] by adding glucose to the analyzed solution, the GOD present on the fiber surface starts to consume more oxygen, then increasing the intensity emission of the Ir-complex (Figure 24a). The detection limit of this system is of 1.0 × 10 −10 m, and sensing is accomplished with typical response times of about 1 s with larger changes in the fluorescence compared with films (Figure 24b,c).…”

Morphological traits essential to electrospun and grafted Nylon‐6 nanofiber membranes for capturing submicron simulated exhaled breath aerosols

“…They have the potential for addressing the issues of fit, durability, and aerosol capture while providing a platform for enhancing diagnostic capabilities at the same time. Furthermore, the use of colorimetric, and lateral flow assays, readable via color changes are far more attractive for nanofiber membrane use, as they can function without battery supplements . By far, the most economically flexible way to produce nanofiber membranes is through the electrospinning process .…”

Electrospinning Superhydrophobic and Antibacterial PS/MWNT Nanofibers onto Multilayer Gas Barrier Films

“…One of the simplest and fastest methods of doing so is through electrospun nanofiber coatings. Nanometer‐sized fibers have gained significant attention in the last two decades in the fields of filtration, membranes, biomedical scaffolds, textile, coatings and even sensors due to their characteristic high surface area per volume ratio . These fibers can be fabricated using electrospinning, which involves the application of a high potential on a slowly flowing polymer solution and, due to the overwhelming electrostatic repulsion experienced by the polymer melt, the sudden burst of the flow to create nanofibers which are collected on the ground .…”