Glucose Tolerance and Serum Lipids Inman After Long‐term Lithium Administration

Vendsborg, P. B.; Prytz, S.

doi:10.1111/j.1600-0447.1976.tb00059.x

Cited by 24 publications

(10 citation statements)

References 16 publications

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“…Effects of lithium on the utilization of carbohydrates have been studied mainly by the glucose tolerance test. An increase in glucose tolerance in subjects given lithium was found by Vendsborg and Rafaelsen (1973), van der Velde and Gordon (1969), and Piirgyi (1972), a decrease was demonstrated by Shopsin et al (1972) while no reliable effect of lithium on glucose tolerance was noted by Vendsborg and Prytz (1976). Un fortunately, differences in the experimental conditions used in these studies preclude direct comparisons between them.…”

Section: Introductionmentioning

confidence: 79%

Impaired Glucose Tolerance in Long-Term Lithium-Treated Patients

Müller‐Oerlinghausen¹,

Passoth²,

Poser³

et al. 1979

Int Pharmacopsychiatry

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The oral glucose tolerance test (oGTT) was performed twice in patients under long-term lithium treatment. Blood glucose and plasma insulin were determined. The oGTT results were evaluated by three criteria (Köbberling-Creutzfeldt, WHO, and Epidemiological Study Group of the European Diabetes Association) and were compared to two representative reference studies from normal populations. The frequency of impaired glucose tolerance in the patients was three times higher than expected on the basis of the studies on normal populations. The variability of the oGTT curves between the first and second tests as well as the steepness of the time-course of the ‘insulinogenic index’ suggested mild disturbances of carbohydrate metabolism (mild diabetes) in some of the patients. It is considered unlikely that the impairment of glucose tolerance in the patients was a direct pharmacological effect of lithium salts. The possible role of age, sex, manic-depressive disease, additional medication, and particularly obesity in the effects of long-term lithium treatment on glucose tolerance is discussed. The authors suggest that the oGTT should be carried out periodically in long-term, lithium-treated patients over the age of 40 years in order to detect abnormalities in their carbohydrate metabolism.

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Section: Introductionmentioning

confidence: 79%

Impaired Glucose Tolerance in Long-Term Lithium-Treated Patients

Müller‐Oerlinghausen¹,

Passoth²,

Poser³

et al. 1979

Int Pharmacopsychiatry

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“…Some studies found an increase in glucose tolerance after 1 day [ Vendsborg and Rafaelson, 1973], but no effect after 6 months [Vendsborg and Prytz, 1976]. On the other hand, Shopsin et al [1972] found a decrease in glucose tolerance after 2 weeks of lithium therapy.…”

Section: Lithium Drug Interactionsmentioning

confidence: 98%

Drug Interactions in Psychiatric Practice

Ragheb¹

1981

Int Pharmacopsychiatry

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The interaction of neuroleptics, tricyclic antidepressants, monoamine oxidase inhibitors, lithium and anxiolytic sedatives with other drugs and food is reviewed with special emphasis on drug interactions commonly encountered in psychiatric practice. Clinical relevance and mechanism of action of such interactions are discussed. An update of the interaction of lithium with prostaglandin inhibitors is presented.

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“…Auch die Wirksamkeit von Lamotrigin ließ sich nicht in einen Zusammenhang mit Gewichtsveränderungen bringen [83]. Ein höheres Ausgangsgewicht und höherer BMI prädisponierte zur Gewichtszunahme unter Lithium−Behandlung [87,160]. Frauen waren von Gewichtszunahme unter Lithium stärker betroffen als Männer [160].…”

Section: Stimmungsstabilisiererunclassified

“…Ein höheres Ausgangsgewicht und höherer BMI prädisponierte zur Gewichtszunahme unter Lithium−Behandlung [87,160]. Frauen waren von Gewichtszunahme unter Lithium stärker betroffen als Männer [160]. Die zugrundeliegende psychiatrische Patholo− gie wurde von Vestergaard und Baptista als weiterer Faktor un− terschiedlich ausgeprägter Gewichtszunahme während der Li− thiumeinnahme gewertet [161,162].…”

Section: Stimmungsstabilisiererunclassified