Glucose Tolerance During and After Pregnancy in Nondiabetic Women in an Urban Population in Tanzania

Lutale, Janet; Justesen, Aafke; Swai, A. B. M.; Alberti, K. G. M. M.; Mclarty, D. F.

doi:10.2337/diacare.16.4.575

Cited by 9 publications

(6 citation statements)

References 10 publications

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“…The majority were descriptive with a range of study designs, including 10 cross‐sectional studies with sample sizes ranging from 189 to 1086 . There were seven prospective studies with sample size ranging from 58 pregnant women recruited during their first trimester to 5026 women recruited during their first antenatal clinic visit and followed until their first post‐natal visit . Furthermore, we found four retrospective studies which were conducted by reviewing hospital delivery registry .…”

Section: Resultsmentioning

confidence: 99%

“…We reviewed six studies from East and Central Africa: four were conducted in East Africa (Tanzania and Ethiopia) and two in Central Africa (Cameroon and Congo) . The oldest study was a community survey in rural Tanzania in 1989 reporting no existence of GDM in the study population (0%) , and the most recent study was published in 2014 on rural and urban clinics in Tanzania reporting a prevalence of 1% (95% CI: 0.2–2.9) and 8.4% (95% CI 6.3–10.9), respectively, using World Health Organisation diagnostic criteria .…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Gestational diabetes mellitus in sub‐Saharan Africa: systematic review and metaregression on prevalence and risk factors

Mwanri

Kinabo

Ramaiya

et al. 2015

Tropical Med Int Health

113

109

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Abstractobjective We systematically reviewed publications on prevalence and risk factors for gestational diabetes mellitus (GDM) in the 47 countries of sub-Saharan Africa.methods We conducted a systematic search in PUBMED and reviewed articles published until June 2014 and searched the references of retrieved articles. We explored sources of heterogeneity among prevalence proportions with metaregression analysis.results Of 1069 articles retrieved 22 studies were included. Half were from West Africa, specifically Nigeria, five from South Africa and six from East and Central Africa. There were differences in screening methods and diagnosis criteria used, even between studies carried out in the same country and same time period. Metaregression analysis indicated high heterogeneity among the studies (I 2 = 100, P < 0.001), which could not be sufficiently explained by study setting, population, diagnostic criteria or time trend, although we observed a relatively higher prevalence in studies carried out after 2000 (5.1% vs. 3.2%), when women at risk were selected (6.5% vs. 3.8%) and when more current diagnostic criteria were used (5.1% vs. 4.2%). Associations with risk factors were reported in six studies. Significant risk factors reported in more than one study were overweight and/ or obesity, family history for type 2 diabetes, previous stillbirth, previous macrosomic child and age >30 years.conclusions There are few studies on prevalence and risk factors for GDM in Sub-Saharan Africa and heterogeneity is high. Prevalence was up to about 14% when high-risk women were studied. Preventive actions should be taken to reduce the short-and long-term complications related to GDM in Sub-Saharan Africa.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Gestational diabetes mellitus in sub‐Saharan Africa: systematic review and metaregression on prevalence and risk factors

Mwanri

Kinabo

Ramaiya

et al. 2015

Tropical Med Int Health

113

109

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“…Two studies in the early 1990s found no evidence of impaired glucose tolerance among pregnant Tanzanian women [14,15]. The present results also suggest that elevated glucose levels are rare among pregnant women in Dar es Salaam, although a conservative definition of exposure was adopted because information was lacking on the timing of meal consumption prior to the glucose test.…”

Section: Discussionmentioning

confidence: 42%

“…Estimates of the prevalence of gestational diabetes in this region are scarce and have varied from 0% to 13.9% [1,11–13]. Impaired glucose tolerance, a precursor to diabetes, has been reported as 0% among pregnant women in Tanzania [14,15] and 7.3% among those in South Africa [16]. …”

Section: Introductionmentioning

confidence: 99%

Maternal hyperglycemia and adverse pregnancy outcomes in Dar es Salaam, Tanzania

Darling

Liu

Aboud

et al. 2014

Intl J Gynecology & Obste

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Objective To evaluate maternal glucose levels during pregnancy as a predictor of adverse perinatal outcomes in Dar es Salaam, Tanzania. Methods Random blood glucose measurements were analyzed from 3833 pregnant women enrolled in a randomized trial to assess the impact of multivitamins on pregnancy outcomes in Dar es Salaam between August 2001 and July 2004. Information on maternal and neonatal morbidity was recorded at monthly study visits, delivery, and 6 weeks postpartum. Generalized estimating equations specified with a binomial distribution and log-link function were used to determine the relationship between elevated glucose (>7.8 mmol/L) and pregnancy outcomes. Results In total, 25 women had elevated glucose (0.7%). Hyperglycemia was associated with an increased risk of delivery before 37 weeks [relative risk (RR), 2.11; 95% confidence interval [CI], 1.07–4.13; P=0.03), delivery before 34 weeks (RR, 4.15; 95% CI, 1.43–12.03, P=0.009), incident gestational hypertension (RR, 2.90; 95% CI, 1.24–6.76; P=0.01), low birth weight (RR, 2.87; 95% CI, 1.18–6.99; P=0.02), reduced newborn head circumference (mean difference, –1.53; 95% CI, –2.51 to –0.62; P=0.001), and stillbirth (RR, 3.38; 95% CI, 1.13–10.08; P=0.03). Conclusion Maternal hyperglycemia is uncommon among pregnant Tanzanian women, but nonetheless seems to increase the risk of several adverse perinatal outcomes.

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“…Zwei weitere Studien aus Tansania berichten von ähnlichen Ergebnissen, jedoch war auch hier die Anzahl der Studienteilnehmer relativ gering (89 bzw. 189) [21,22] .…”

Section: Die Dynamik Des Schwangerschaftsdiabetes In Ostafrikaunclassified

Schwangerschaftsdiabetes in Ostafrika: eine Erkrankung, die zu wenig Beachtung findet?

Zeck

Lang

Panzitt

et al. 2009

Gynäkol Geburtshilfliche Rundsch

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Aktuelle epidemiologische Daten zeigen, dass es in den kommenden Jahrzehnten zu einem starken Anstieg der Inzidenz von Typ-2-Diabetes und somit des Schwangerschaftsdiabetes vor allem in den so genannten Entwicklungsländern kommen wird. Obwohl die Mehrzahl von Schwangerschaften und Entbindungen in diesen Ländern stattfinden, ist ausgesprochen wenig über die Prävalenz von Schwangerschaftsdiabetes in Ostafrika bekannt. Eine fetale, diabetische Störung, die intrauterin durch metabolische Einflüsse des mütterlichen Diabetes ausgelöst wird, führt letztlich zu einer Erhöhung der Prävalenz von Diabetes in den darauffolgenden Generationen. Unsere Datenerhebung in einem ostafrikanischen Tertiärzentrum zeigt, dass im Jahre 2007 3,1% der Neugeborenen ein Geburtsgewicht von mehr als 4000 g (Mittelwert 4300 g; Min. 4000 g, Max. 5600 g) aufwiesen, wobei das durchschnittliche Geburtsgewicht während dieses Zeitraumes bei nur 3046 g (Min. 600 g, Max. 3200 g) lag. Aufgrund persönlicher Erfahrungen in Ostafrika mutmassen die Autoren, dass dieser Erkrankung trotz ihrer enormen Tragweite vor allem in den Ländern der Dritten Welt zu wenig Beachtung geschenkt wird. Es muss damit gerechnet werden, dass der afrikanische Kontinent in naher Zukunft neben den bekannten Infektionserkrankungen wie HIV/AIDS zunehmend mit Stoffwechselerkrankungen wie Typ-2-Diabetes und Schwangerschaftsdiabetes zu kämpfen haben wird.

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Glucose Tolerance During and After Pregnancy in Nondiabetic Women in an Urban Population in Tanzania

Abstract: We conclude that women during pregnancy in an urban African setting show little change in glucose tolerance. This contrasts with women in both the developed world, where glucose tolerance worsens, and in a rural African environment, where glucose tends to improve.

Cited by 9 publications

References 10 publications

Gestational diabetes mellitus in sub‐Saharan Africa: systematic review and metaregression on prevalence and risk factors

Gestational diabetes mellitus in sub‐Saharan Africa: systematic review and metaregression on prevalence and risk factors

Maternal hyperglycemia and adverse pregnancy outcomes in Dar es Salaam, Tanzania

Schwangerschaftsdiabetes in Ostafrika: eine Erkrankung, die zu wenig Beachtung findet?

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