Glucose Tolerance in Depressed Inpatients, under Treatment with Mirtazapine and in Healthy Controls

Hennings, Johannes M.; Ising, Marcus; Grautoff, Steffen; Himmerich, Hubertus; Pollmächer, Thomas; Schaaf, Ludwig

doi:10.1055/s-0029-1237361

Cited by 29 publications

(15 citation statements)

References 11 publications

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“…However, diabetes and “pre-diabetes” (impaired glucose tolerance and impaired fasting glucose) are diagnosed only by measured hyperglycemia (American Diabetes Association, 2013). Of note, some depressed individuals manifest insulin resistance (Nathan et al, 1981; Menna-Perper et al, 1984; Winokur et al, 1988; Okamura et al, 2000; Hennings et al, 2010) which improves with depression treatment (Nathan et al, 1981; Okamura et al, 2000; Hennings et al, 2010; Mueller et al, 1969; Weber-Hamann et al, 2008). …”

Section: Introductionmentioning

confidence: 99%

The relationship between fasting serum glucose and cerebral glucose metabolism in late-life depression and normal aging

Marano

Workman

Lyman

et al. 2014

Psychiatry Research: Neuroimaging

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Evidence exists for late-life depression (LLD) as both a prodrome of and risk factor for Alzheimer’s disease (AD). The underlying neurobiological mechanisms are poorly understood. Impaired peripheral glucose metabolism may explain the association between depression and AD given the connection between type 2 diabetes mellitus with both depression and AD. Positron emission tomography (PET) measures of cerebral glucose metabolism are sensitive to detecting changes in neural circuitry in LLD and AD. Fasting serum glucose (FSG) in non-diabetic young (YC; n=20) and elderly controls (EC; n=12) and LLD patients (n=16) was correlated with PET scans of cerebral glucose metabolism on a voxel-wise basis. The negative correlations were more extensive in EC versus YC and in LLD patients versus EC. Increased FSG correlated with decreased cerebral glucose metabolism in LLD patients to a greater extent than in EC in heteromodal association cortices involved in mood symptoms and cognitive deficits observed in LLD and dementia. Negative correlations in YC were observed in sensory and motor regions. Understanding the neurobiological consequences of diabetes and associated conditions will have substantial public health significance given that this is a modifiable risk factor for which prevention strategies could have an important impact on lowering dementia risk.

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Section: Introductionmentioning

confidence: 99%

The relationship between fasting serum glucose and cerebral glucose metabolism in late-life depression and normal aging

Marano

Workman

Lyman

et al. 2014

Psychiatry Research: Neuroimaging

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show abstract

“…About 7.8 % of the US population in 2007 ( American Diabetes Association, 2010 ) and about 200 million people worldwide ( Wild et al, 2004 ) suff ered from diabetes in 2000. Although the direction of the association and possible reasons and mechanisms remain unclear so far ( Hennings et al, 2010, Weber et al, 2000, there is evidence that depression is a relevant comorbidity in diabetic subjects. In addition, there is suffi cient evidence for an association between diabetes and depression.…”

Section: Introduction ▼mentioning

confidence: 99%

Low-Level Subchronic Arsenic Exposure from Prenatal Developmental Stages to Adult Life Results in an Impaired Glucose Homeostasis

Dávila-Esqueda¹,

Morales²,

Jiménez-Capdeville³

et al. 2011

Exp Clin Endocrinol Diabetes

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We evaluated how low-level (3 ppm) subchronic inorganic arsenic (iAs) exposure from prenatal developmental stages until adult life affects glucose homeostasis. Biochemical parameters of glucose and lipid metabolism, pancreatic insulin and glycosylated haemoglobin were determined in 4-month-old female offspring of adult Wistar rats. Pancreatic histology was also performed. Statistical comparisons between control and iAs-treated groups were performed by unpaired two-tailed Student's t-test. Statistical significance was set at p<0.05. We found that iAs treatment resulted in an impaired glucose tolerance test, suggestive of impaired glucose metabolism. This group was found to have hyperglycaemia and high levels of HOMA-IR, glycosylated haemoglobin, cholesterol and pancreatic insulin compared to control rats. However, plasma insulin, triglycerides and high-density lipoprotein cholesterol were not different from control rats. Moreover, β-cell damage found in iAs-treated rats consisted of cells with a nucleus with dense chromatin and predominance of eosinophilic cytoplasm, as well as changes in the pancreatic vasculature. The current study provided evidence that subchronic iAs exposure at 3 ppm from prenatal developmental stages to adult life resulted in damage to pancreatic β cells, affected insulin secretion and demonstrated altered glucose homeostasis, thus supporting a causal association between iAs exposure and diabetes.

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“…The cross-sectional design of this study cannot show cause/effect between elevated fasting blood glucose and depressive symptoms. It may be notable, however, that several previous studies have suggested that depressed patients experience improved glucose metabolism after treatment with antidepressants as well as cognitive behavioral therapy [21–23]. …”

Section: Discussionmentioning

confidence: 99%

Fasting Blood Glucose and Depressive Mood among Patients with Mental Illness in a Medicaid Managed Care Program

Kahn

McIntyre

Rafalson

et al. 2011

Depression Research and Treatment

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Objective. This study explores the relationship between depressive symptoms, as measured by the PHQ-9 depression screen and blood glucose levels among patients with diabetes enrolled in Gold Choice, a Medicaid managed care program for individuals with mental illness and/or substance abuse. Methods. The PHQ-9 was mailed to 454 Gold Choice members and a questionnaire was mailed to their physicians requesting current HbA1c% and fasting blood glucose (FBG) levels. The pearson product-moment correlation was used to describe the association between PHQ-9 scores and FBG levels. Results. The PHQ-9 response rate was 55% (N = 249). Laboratory results were received for 141 patients. The correlation between FBG and PHQ-9 scores was modest but statistically significant: r = 0.21 , P = 0.015. Conclusion. A statistically significant association was found between FBG and PHQ-9 depression scores. This finding supports current recommendations that physicians be alert to depressive symptoms among patients with diabetes or impaired glucose metabolism.

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Glucose Tolerance in Depressed Inpatients, under Treatment with Mirtazapine and in Healthy Controls

Cited by 29 publications

References 11 publications

The relationship between fasting serum glucose and cerebral glucose metabolism in late-life depression and normal aging

The relationship between fasting serum glucose and cerebral glucose metabolism in late-life depression and normal aging

Low-Level Subchronic Arsenic Exposure from Prenatal Developmental Stages to Adult Life Results in an Impaired Glucose Homeostasis

Fasting Blood Glucose and Depressive Mood among Patients with Mental Illness in a Medicaid Managed Care Program

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