2017
DOI: 10.1038/srep40661
|View full text |Cite
|
Sign up to set email alerts
|

Glucose tolerance in mice exposed to light–dark stimulus patterns mirroring dayshift and rotating shift schedules

Abstract: Glucose tolerance was measured in (nocturnal) mice exposed to light–dark stimulus patterns simulating those that (diurnal) humans would experience while working dayshift (DSS) and 2 rotating night shift patterns (1 rotating night shift per week [RSS1] and 3 rotating night shifts per week [RSS3]). Oral glucose tolerance tests were administered at the same time and light phase during the third week of each experimental session. In contrast to the RSS1 and RSS3 conditions, glucose levels reduced more quickly for … Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
2

Citation Types

0
23
0

Year Published

2018
2018
2024
2024

Publication Types

Select...
10

Relationship

0
10

Authors

Journals

citations
Cited by 29 publications
(23 citation statements)
references
References 33 publications
0
23
0
Order By: Relevance
“…Oral glucose tolerance in the light phase after a 14 h fast was worsened when mice were subjected to a shift-work paradigm with either 1 or 3 rotating night shifts (i.e., an inverted L:D cycle) per week for a duration of 3 weeks (22). In rats several risk factors such as increased abdominal fat, increased fasting glucose and increased glycemia in the light phase during an OGTT were found after 60 days of inverted feeding (i.e., 20% of caloric intake during the active phase and 80% of caloric intake during the inactive phase) (23).…”
Section: Discussionmentioning
confidence: 99%
“…Oral glucose tolerance in the light phase after a 14 h fast was worsened when mice were subjected to a shift-work paradigm with either 1 or 3 rotating night shifts (i.e., an inverted L:D cycle) per week for a duration of 3 weeks (22). In rats several risk factors such as increased abdominal fat, increased fasting glucose and increased glycemia in the light phase during an OGTT were found after 60 days of inverted feeding (i.e., 20% of caloric intake during the active phase and 80% of caloric intake during the inactive phase) (23).…”
Section: Discussionmentioning
confidence: 99%
“…[7]. Extensive studies have shown that exposure of photo-biologically active light at inappropriate timing and intensity [8,9] affects human health eliciting retinal damage [10,11], glucose tolerance impairments [12][13][14] and negative impact on psychological and physiological health [13][14][15]. There are also past works on the effects of melatonin suppression due to light at night (LAN) on certain types of cancers such as breast cancer [16], colorectal cancer [17] and endometrial cancer [18] and the development of tumors [19].…”
Section: Introductionmentioning
confidence: 99%
“…Different experimental procedures to assess the impact of repeated LD shifts on the circadian system function and its relationship with health have been used under laboratory conditions. Most of these studies are based on exposing experimental animals, mainly nocturnal rodents (mice and rats), to jetlag‐like shifting paradigms (eg chronic phase advances or delays in their LD cycles with a determined inter‐shift intervals . However, considerably less of such studies have been performed in diurnal animals, and to the best of our knowledge, no studies have been performed in dual‐phasing species, like the degus.…”
Section: Discussionmentioning
confidence: 99%