“…This led to the identification of several T-2 metabolites, including HT-2, 2 , neosolaniol (NEO), 6 , 3′-OH-T-2, 3 , 3′-hydroxy-HT-2 (3′-OH-HT-2), 7 , de-epoxy-HT-2, 8 , de-epoxy-3′-hydroxy-HT-2, 9 , as well as some glucuronide conjugates. ,, Hydrolysis (at C-4, C-8, and C-15 parts), hydroxylation (at C-3′, C-7, and C-9), deepoxidation (at C12,13), and conjugative reactions (at C-3 and C-4 for HT-2) are the major metabolic pathways of T-2 in animals and human. − ,, However, there are still questions surrounding the metabolism of T-2. The majority of this research focused on experimental animals, such as mice and rats. ,, In other animal species, limited information is available concerning the metabolism of T-2. , Therefore, the metabolic profiles of T-2 in farm animals, such as poultry and pigs, are still unclear. , Due to the likelihood that T-2 along with its metabolites remain in the edible tissues of livestock animals, a better elucidation of T-2 metabolism in farm animals becomes critically important, in turn providing information to evaluate human exposure to T-2 residues. ,, The importance of this research on farm animals is emphasized by the significant interspecies difference >on the metabolism of T-2. ,, Hydrolysis is the primary metabolic pathway of T-2 for rats, mice and humans, and the major metabolite in these cases is HT-2, 2 . , In swine, glucuronide-conjugated metabolites were the main metabolites, , while in chickens, the hydroxylated metabolite 3′-OH-HT-2, 7 , and several uncharacterized molecules are considered to be of importance . Given these clear interspecies differences, it is necessary to carry out a comprehensive comparison metabolism of T-2.…”