GLUT-1 expression in mesenchymal tumors: an immunohistochemical study of 247 soft tissue and bone neoplasms

Ahrens, William A.; Ridenour, Robert V.; Caron, Bolette L.; Miller, Dylan V.; Folpe, Andrew L.

doi:10.1016/j.humpath.2008.03.002

Cited by 72 publications

(43 citation statements)

References 25 publications

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“…Meanwhile, among AS and HE, GLUT1 expression is limited to epithelioid areas instead of well-differentiated retiform or arborising canalicular areas. This may suggest high glucose consumption of poorly differentiated epithelioid areas of both AS and HE, as also suggested by Ahrens et al (28). Although GLUT1 had a tendency to be overexpressed in AS rather than HE, GLUT1 expression did not significantly correlate with either grade or survival of the cases; this result partly could be explained by the relative small number of positive cases.…”

Section: Morphological Findingsmentioning

confidence: 54%

The importance of consumption of the epidermis in malignant melanoma and correlation with clinicopathological prognostic parameters

Seçkin

Ozgun²

2011

TJPATH

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Objective: angiosarcomas and hemangioendotheliomas are rare malignant vascular neoplasms (MVTs). Here, we reviewed the clinicomorphological characteristics of 27 MVTs with the implementation of two novel immunohistochemical markers: GLUT1, and FKBP12.Material and Method: MVTs, except for Kaposi's sarcoma, were retrieved from the archive and reviewed. Tumor size, the presence of hemorrhage and necrosis, growth pattern, cellularity, cellular characteristics and mitotic activity were recorded as morphological variables. immunohistochemically, CD34, CD31, GLUT1, FKBP12, Mdm2, p53, c-kit, and CD99 were applied. Clinical information was gathered from hospital records and computer-based patient data systems. Results:The median age was 53 years (range 16-77). Extremities (37%) were the most common primary site followed by the head and neck. Five of 16 (31%) low grade and 7 of 11 (64%) high grade tumors were metastasized to varying organs, mainly the liver and lungs. The median survival was 49 months. ninety percent of high grade tumors were larger than 3 cm. Hemorrhage and necrosis were seen in 85% and 41% of cases, respectively. nuclear pleomorphism, cellularity and mitotic activity were higher in high grade tumors than in low grade ones (p<0.0001). While 68% of the cases expressed CD34, 81% of them were positive with CD31. all cases except one low grade tumor were strongly and diffusely stained with FKBP12. Significant GLUT1 expression was observed in 23% of cases, especially in areas showing epithelioid morphology. Either Mdm2 or p53 was positive in over one third of the tumors. Conclusion:The studied markers were not able to distinguish between low and high grade MVTs. FKBP12 may take a role in the diagnostic panel of MVTs. GLUT1 expression, previously proposed for the diagnosis of infantile hemangioma, should be assessed carefully since almost one quarter of MVTs were also GLUT1 positive.

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Section: Morphological Findingsmentioning

confidence: 54%

The importance of consumption of the epidermis in malignant melanoma and correlation with clinicopathological prognostic parameters

Seçkin

Ozgun²

2011

TJPATH

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“…Another way to differentiate between congenital and infantile hemangiomas is by using glucose transporter 1 (GLUT1), an erythrocyte-type glucose transporter, as a marker, since it is expressed in infantile but not in congenital hemangiomas [1,10,11]. The biopsy specimen in the current case was not tested for GLUT1 due to insufficient pathological specimen.…”

Section: Discussionmentioning

confidence: 99%

Giant cranial and cerebellar hemangioma treated with propranolol

et al. 2014

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“…Expression of GLUT1 has also been demonstrated in normal perineural cells and perineuriomas. 270 These S100 À , benign peripheral nerve sheath tumors are also positive with EMA but often in a focal and weak pattern because of their very thin and widely separated cytoplasmic processes. Higher antisera concentrations or longer incubation times may be required for EMA in perineuriomas, in comparison to that used for epithelial tumors.…”

Section: -261mentioning

confidence: 99%

Immunohistochemistry in Dermatopathology

Ferringer

2015

Archives of Pathology &Amp; Laboratory Medicine

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Context.-Immunohistochemistry is not a diagnostic test but a highly valuable tool that requires interpretation within a context.Objective.-To review the current status and limitations of immunohistochemistry in dermatopathology.Data Sources.-English-language literature published between 1980 and 2014.Conclusions.-Although immunohistochemistry is rarely completely specific or sensitive, it is an important adjunctive technique in dermatopathology and can be helpful in a series of diagnostic dilemmas.

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GLUT-1 expression in mesenchymal tumors: an immunohistochemical study of 247 soft tissue and bone neoplasms

Cited by 72 publications

References 25 publications

The importance of consumption of the epidermis in malignant melanoma and correlation with clinicopathological prognostic parameters

The importance of consumption of the epidermis in malignant melanoma and correlation with clinicopathological prognostic parameters

Giant cranial and cerebellar hemangioma treated with propranolol

Immunohistochemistry in Dermatopathology

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