Glut1 and Glut3 expression in lymphoma and their association with tumor intensity on 18F-fluorodeoxyglucose positron emission tomography

Khandani, Amir H.; Dunphy, Cherie H.; Meteesatien, Patcharica; Dufault, Darin; Ivanović, Marija; Shea, Thomas C.

doi:10.1097/mnm.0b013e32832cc295

Cited by 33 publications

(24 citation statements)

References 19 publications

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“…Although GLUT-1 expression has been reported as being associated with poor treatment outcomes in many cancers [23,24], there are limited data regarding the expression of GLUT-1 in lymphomas. Furthermore, the expression of GLUT-1 was variable in previous studies [25][26][27], one report showing no staining of GLUT-1 in DLBCL [25]. The expression of GLUT-1 mainly begins in the endothelial cells of microvessels in early hypoxia, and then it is expressed around necrotic areas as the tumor progresses.…”

Section: Discussionmentioning

confidence: 85%

Hypoxia-associated protein expression in primary central nervous system diffuse large B-cell lymphoma: does it predict prognosis?

Kim

et al. 2011

Leukemia & Lymphoma

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Hypoxia-associated proteins are commonly expressed as a consequence of disturbances in microcirculation. However, the clinical relevance of the proteins has never been studied in primary central nervous system lymphoma (PCNSL). The expression of hypoxia-inducible factor 1α (HIF-1α) and its downstream proteins, vascular endothelial growth factor (VEGF) and glucose transporter 1 (GLUT-1), were evaluated in a central nervous system (CNS) lymphoma xenograft model and in human PCNSL tissue. In the CNS lymphoma xenograft model, the expression of HIF-1α, VEGF, and GLUT-1 co-localized in subsets of lymphoma cells adjacent to necrosis. In tumor specimens from 51 patients with PCNSL, positive HIF-1α staining was found in 26 patients (51.0%), positive VEGF in 30 (58.8%), and positive GLUT-1 in 17 (33.3%), and HIF-1α showed a significant correlation with VEGF (p < 0.05). However, no significant association was seen between hypoxia-associated protein positivity and unfavorable clinical characteristics. Thus, the results failed to show an association with shorter overall survival or time to progression, except that the percentage of lymphoma cells positive for GLUT-1 (>20%) was significantly associated with worse survival. In conclusion, hypoxia-associated proteins were expressed in PCNSL, suggesting a hypoxic microenvironment. However, the prognostic relevance of these proteins for PCNSL was not demonstrated in this study.

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Section: Discussionmentioning

confidence: 85%

Hypoxia-associated protein expression in primary central nervous system diffuse large B-cell lymphoma: does it predict prognosis?

Kim

et al. 2011

Leukemia & Lymphoma

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“…A low number of pathognomic HRS cells expresses low and alternating number of glucose-transporters and hexokinases involved in glucose metabolism [75]. A relation between FDG uptake and transporter expression of the tumor cells could not be found.…”

Section: Prospective Therapeutic Solutions and Possibilities Of Targementioning

confidence: 85%

Immunologic pathomechanism of Hodgkin's lymphoma

Jóna

Szodoray

Illés

2013

Experimental Hematology

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“…Hence, imaging of these biomarkers would provide added benefit at the time of diagnosis. In another study, the intensity of 18 F-FDG uptake in lymphomas was directly correlated with Glut1 expression in patients with HL and NHL [148]. Thus, identification of biomarkers expressed in more types of lymphoma may lead to the production of more clinically relevant imaging tools.…”

Section: Discussion and Future Perspectivesmentioning

confidence: 99%

Lymphoma: current status of clinical and preclinical imaging with radiolabeled antibodies

England

Cai

2016

Eur J Nucl Med Mol Imaging

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Lymphoma is a complex disease that arises from cells of the immune system with an intricate pathology. While lymphoma may be classified as Hodgkin or non-Hodgkin, each type of tumor is genetically and phenotypically different and highly invasive tissue biopsies are the only method to investigate these differences. Noninvasive imaging strategies, such as immunoPET, can provide a vital insight into disease staging, monitoring treatment response in patients, and dose planning in radioimmunotherapy. ImmunoPET imaging with radiolabeled antibody-based tracers may also assist physicians in optimizing treatment strategies and enhancing patient stratification. Currently, there are two common biomarkers for molecular imaging of lymphoma, CD20 and CD30, both of which have been considered for investigation in preclinical imaging studies. In this review, we examine the current status of both preclinical and clinical imaging of lymphoma using radiolabeled antibodies. Additionally, we briefly investigate the role of radiolabeled antibodies in lymphoma therapy. As radiolabeled antibodies play critical roles in both imaging and therapy of lymphoma, the development of novel antibodies and the discovery of new biomarkers may greatly affect lymphoma imaging and therapy in the future.

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Glut1 and Glut3 expression in lymphoma and their association with tumor intensity on 18F-fluorodeoxyglucose positron emission tomography

Abstract: Intensity of lymphoma on FDG PET is likely associated with Glut1 expression. The nonlymphomatous, benign cells may play an important role in visualization of lymphoma on FDG PET.

Cited by 33 publications

References 19 publications

Hypoxia-associated protein expression in primary central nervous system diffuse large B-cell lymphoma: does it predict prognosis?

Hypoxia-associated protein expression in primary central nervous system diffuse large B-cell lymphoma: does it predict prognosis?

Immunologic pathomechanism of Hodgkin's lymphoma

Lymphoma: current status of clinical and preclinical imaging with radiolabeled antibodies

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