GLUT12—A promising new target for the treatment of insulin resistance in obesity and type 2 diabetes

Intracellular events in diabetes mellitus – Behind the scenes

“…They found that GLUT12 and GLUT4 localize to the plasma membrane upon insulin stimuli 6 . Since in a previous study GLUT4 was observed to be less expressed in obese insulin resistant patients, 7 Gil‐Itrube’s group screened for GLUT12 expression levels in obese mice. Strikingly, insulin sensitivity was reduced by decreased membrane‐expressed GLUT12.…”

Adipose tissue—more than just fat

“…Glucagon and insulin are two major hormones balancing glucose utilization, production, and its uptake from blood into adipose as well as muscle tissue. The trans membrane protein GLUT4 is a main insulin‐sensitive transporter responsible for glucose uptake . Recently, GLUT12 has gained attention as a promising new target for the treatment of insulin resistance .…”

“…The trans membrane protein GLUT4 is a main insulin‐sensitive transporter responsible for glucose uptake . Recently, GLUT12 has gained attention as a promising new target for the treatment of insulin resistance . It was previously shown by Purcell et al that transgenic GLUT12‐overexpressing mice show increased insulin sensitivity mediated by an increased glucose clearance rate in insulin‐responsive tissues .…”

“…A number of articles addressing basic mechanisms related to obesity have recently appeared in Acta physiologica. [2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19] One area of clinical relevance for obese patients is the immune system. Duan et al 20 recapitulate the connections between a high-fat diet and diseases.…”

“…2 Recently, GLUT12 has gained attention as a promising new target for the treatment of insulin resistance. 2 It was previously shown by Purcell et al that transgenic GLUT12-overexpressing mice show increased insulin sensitivity mediated by an increased glucose clearance rate in insulin-responsive tissues. 24 In a recent study Gil-Iturbe et al describe GLUT12 as a leptin-, adiponectin-and insulin-responsive receptor that plays a role in the modulation of glucose absorption.…”