Glutamate Injection Into the Cuneiform Nucleus in Rat, Produces Correlated Single Unit Activities in the Kolliker-Fuse Nucleus and Cardiovascular Responses

Nasimi, Ali; Shafei, Mohammad Naser; Alaei, Hojjatallah

doi:10.1016/j.neuroscience.2012.07.041

Cited by 19 publications

(10 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…More important in the context of SUDEP however is that several structures in the most severely affected region, e.g. the periaqueductal gray and the cuneiform nucleus, belong to a network of brainstem structures involved the cardio-vascular control (Pelosi et al, 2012; Dampney et al, 2013; Nasimi et al, 2012; Korte et al, 1992). Structural abnormalities in these regions could therefore impair the autonomic control in the interictal state (Surges et al, 2009) and cause critical autonomic disturbances, e.g., cardiac arrhythmias and respiratory impairment severe enough to result in hypoxemia, during the ictal and immediately postictal period (Ryvlin et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

Evidence for brainstem network disruption in temporal lobe epilepsy and sudden unexplained death in epilepsy

Mueller

Bateman

Laxer

2014

NeuroImage: Clinical

118

View full text Add to dashboard Cite

The symptoms witnessed in unexplained death in epilepsy (SUDEP) suggest a breakdown of central autonomic control. Since the brainstem plays a crucial role in autonomic control, the objectives of this study were 1. To investigate if temporal lobe epilepsy (TLE) is associated with brainstem atrophy and to characterize it using graph Analysis 2. To compare the findings with those in two probable TLESUDEP. T1 images were obtained from 17 controls, 30 TLE (16 with mesial-temporal-sclerosis (TLE-MTS) and 14 without (TLE-no)) and from 2 patients who died of SUDEP. The brainstem was extracted, warped onto a brainstem atlas and Jacobian determinants maps (JDM) calculated. SPM8 was used to compare the JDMs at the group level, z-score maps were calculated for single subject analysis. Brainstem regions encompassing autonomic structures were identified based on macroscopic landmarks and mean z-scores from 5 × 5 × 5 voxel cubes extracted to calculate a new measure called atrophy-similarity index (ASI) for graph analysis. TLE-MTS had volume loss in the dorsal mesencephalon. The SUDEP cases had severe and more extensive volume loss in the same region. Nodal degrees and participation coefficients were decreased and local efficiency increased in SUDEP compared to controls. TLE is associated with volume loss in brainstem regions involved in autonomic control. Structural damage in these regions might increase the risk for a fatal dysregulation during situations with increased demand such as following severe seizures.

show abstract

Section: Discussionmentioning

confidence: 99%

Evidence for brainstem network disruption in temporal lobe epilepsy and sudden unexplained death in epilepsy

Mueller

Bateman

Laxer

2014

NeuroImage: Clinical

118

View full text Add to dashboard Cite

show abstract

“…After anesthesia the femoral artery and vein catheterized by a polyethylene tube 50 which was filled with heparinized saline to recording of blood pressure and drug injection, respectively. Arterial catheter connected to a blood pressure transducer and cardiovascular parameters [mean arterial pressure (MAP), systolic blood pressure (SBP) and heart rate (HR)] were recorded [ 14 , 15 ] by a power lab instrument(ID instrument, Australia). After stabilization of cardiovascular parameters, In AngII group, AngII (300 mg/kg) was intravenously administered during 2 min to achieve a high blood pressure.…”

Section: Methodsmentioning

confidence: 99%

Beneficial Cardiovascular Effects of Hydroalcoholic Extract from Crocus Sativus in Hypertension Induced by Angiotensin II

et al. 2019

View full text Add to dashboard Cite

“…The role of CnF in cardiovascular regulation has been evaluated ( Shafei et al, 2012 ). For example, our previous study indicated that glutamate increased blood pressure ( Nasimi, Shafei, & Alaei, 2012 ), and the cholinergic system decreased cardiovascular parameters ( Shafei, Niazmand, Hosseini, & Daloee, 2013 ). Despite the role of CnF in cardiovascular regulation, we previously indicated that inactivation of this nucleus by Cobalt Chloride (CoCl 2 ) did not change basic cardiovascular parameters ( Shafei et al, 2012 ).…”

Section: Introductionmentioning

confidence: 99%

Cardiovascular Effect of Cuneiform Nucleus During Hemorrhagic Hypotension

Mohebbati

Hosseini

Khazaei

et al. 2020

Basic Clin. Neurosci. J.

View full text Add to dashboard Cite

The underlying mechanism responsible for the cardiovascular response to Hemorrhage (HEM) is still unknown; however, several brain areas, such as the Cuneiform nucleus (CnF) have shown to be involved. In this study, the cardiovascular effect of the CnF during HEM was evaluated. Methods: The animals were divided into the following groups: 1. Vehicle; 2. HEM; 3. Cobalt chloride (CoCl 2); 4. CoCl 2 +saline; and 5. CoCl 2 +HEM. Catheterization of the left and right femoral artery was performed to record blood pressure and blood withdrawal, respectively. Saline and CoCl 2 were microinjected into the CnF nucleus, and then blood withdrawal was done for HEM induction. Cardiovascular regulation throughout the experiments was recorded and changes (∆) in the Systolic Blood Pressure (SBP), Mean Arterial Pressure (MAP) and Heart Rate (HR) were calculated over time and compared with those treated with saline and HEM, using repeated-measures ANOVA. Results: HEM significantly reduced ∆SBP and ∆MAP and augmented ∆HR than the vehicle group. CoCl 2 did not significantly affect basic ∆SBP, ∆MAP, and ∆HR compared with the vehicle group. However, injection of CoCl 2 into the CnF before HEM (CoCl 2 +HEM group) significantly decreased ∆SBP, ∆MAP, and tachycardia, induced by HEM. Conclusion: Our results indicated that blockade of the CnF by CoCl 2 significantly reduced the hypotension and tachycardia, induced by HEM indicating the involvement of CnF in cardiovascular regulation during HEM.

show abstract

Glutamate Injection Into the Cuneiform Nucleus in Rat, Produces Correlated Single Unit Activities in the Kolliker-Fuse Nucleus and Cardiovascular Responses

Cited by 19 publications

References 21 publications

Evidence for brainstem network disruption in temporal lobe epilepsy and sudden unexplained death in epilepsy

Evidence for brainstem network disruption in temporal lobe epilepsy and sudden unexplained death in epilepsy

Beneficial Cardiovascular Effects of Hydroalcoholic Extract from Crocus Sativus in Hypertension Induced by Angiotensin II

Cardiovascular Effect of Cuneiform Nucleus During Hemorrhagic Hypotension

Contact Info

Product

Resources

About