Glutamate receptors activate Ca2+ mobilization and Ca2+ influx into astrocytes.

Glaum, Steven R.; Holzwarth, James A.; Miller, Richard J.

doi:10.1073/pnas.87.9.3454

Cited by 208 publications

(150 citation statements)

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“…40 -42 Subsequent in vitro experiments have demonstrated that glial cells express the very same diverse variety of neurotransmitter receptors and ion channels as do neurons, [43][44][45][46][47][48][49][50][51][52][53][54][55] thus raising the question of the role for neuroglia in information processing in the brain. Further experiments have found that the expression pattern of neurotransmitter receptors in situ is very much restricted by the immediate neurotransmitter environment; as a consequence glial cells are properly endowed to sense the neurotransmitters released in their territorial domains.…”

Section: Signaling In Neuronal-glial Circuits 1) Glial Cells Express mentioning

confidence: 99%

Astrocytes in Alzheimer's Disease

et al. 2010

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Summary:The circuitry of the human brain is formed by neuronal networks embedded into astroglial syncytia. The astrocytes perform numerous functions, providing for the overall brain homeostasis, assisting in neurogenesis, determining the micro-architecture of the grey matter, and defending the brain through evolutionary conserved astrogliosis programs.Astroglial cells are engaged in neurological diseases by determining the progression and outcome of neuropathological process. Astrocytes are specifically involved in various neurodegenerative diseases, including Alzheimer's disease, amyotrophic lateral sclerosis, Parkinson's disease, and various forms of dementia. Recent evidence suggest that early stages of neurodegenerative processes are associated with atrophy of astroglia, which causes disruptions in synaptic connectivity, disbalance in neurotransmitter homeostasis, and neuronal death through increased excitotoxicity. At the later stages, astrocytes become activated and contribute to the neuroinflammatory component of neurodegeneration.

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Section: Signaling In Neuronal-glial Circuits 1) Glial Cells Express mentioning

confidence: 99%

Astrocytes in Alzheimer's Disease

et al. 2010

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“…Astrocytes, a sub-type of glial cells present in the CNS, express the receptor for Glu. Upon binding of Glu, membrane-bound ion channels open immediately, promoting Ca 2+ influx [27][28][29] . Therefore, astrocytes represent an ideal system to monitor Glu activation of cells using real-time single-cell ratiometric Ca 2+ imaging.…”

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confidence: 99%

Organic electronics for precise delivery of neurotransmitters to modulate mammalian sensory function

et al. 2009

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“…However, it remained to be determined whether [Ca 2~] 1 oscillations are induced in native neural cells by activation of mGluR5. Several studies have indicated that glutamate elicits oscillatory [Ca 2~] 1responses in cultured astrocytes through [Ca 2~]mobilization (Cornell-Bell et al, 1990a;Glaum et al, 1990;de Barry et al, 1991;Holzwarth et al, 1994). It has also recently been reported that mGluR5 is preferentially expressed in cultured astrocytes and that this expression is up-regulated by specific growth factors such as basic fibroblast growth factor (bFGF), epidermal growth factor (EGF), and transforming growth factor-a (TGF-a) (Miller et al, 1995).…”

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confidence: 99%

The Metabotropic Glutamate Receptor mGluR5 Induces Calcium Oscillations in Cultured Astrocytes via Protein Kinase C Phosphorylation

Nakahara

Okada²,

Nakanishi

1997

Journal of Neurochemistry

133

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Abstract:The metabotropic glutamate receptor mGluR5, but not the closely related mGluRl, is expressed in cultured astrocytes, and this expression is up-regulated by specific growth factors. We investigated the capability and underlying mechanisms of mGluR5 to induce oscillatory responses of intracellular calcium concentration ([Ca 2~]) in cultured rat astrocytes. recordings indicated that an mGluR-selective agonist, (1 S,3R)-1 -aminocyclopentane-1,3-dicarboxylate (1 S,3R-ACPD), elicits [Ca2~], oscillations in good agreement with the growth factor-induced up-regulation of mGluR5 in cultured astrocytes. A protein kinase C (PKC) inhibitor, bisindolylmaleimide I, converted a 1S,3R-ACPD-mediated oscillatory response into a nonoscillatory response. In addition, the PKC activator phorbol 12-myristate 13-acetate completely abolished the [Ca2~]increase. These and other pharmacological properties of 1S,3R-ACPD-induced [Ca2~]õscillations correlate well with those of the cloned mGluR5 characterized in heterologous expression systems. Furthermore, the potential involvement of protein phosphatases in [Ca2~]õscilla-tions is suggested. The present study demonstrates that mGluR5 is capable of inducing [Ca2~] 1 oscillations in cultured astrocytes and that phosphorylation/dephosphorylation of mGluR5 is critical in [Ca 2~]oscillations, analogous to the cloned mGluR5 expressed in heterologous cell lines.

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Glutamate receptors activate Ca2+ mobilization and Ca2+ influx into astrocytes.

Cited by 208 publications

References 34 publications

Astrocytes in Alzheimer's Disease

Astrocytes in Alzheimer's Disease

Organic electronics for precise delivery of neurotransmitters to modulate mammalian sensory function

The Metabotropic Glutamate Receptor mGluR5 Induces Calcium Oscillations in Cultured Astrocytes via Protein Kinase C Phosphorylation

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