1963
DOI: 10.1021/cr60226a004
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Glutamic Acid: Chemical Syntheses and Resolutions.

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Cited by 7 publications
(4 citation statements)
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“…For example, the carbonyl group of LA undergoes the Knoop ± Oesterlin reductive amination. 77 This reaction is catalysed by Co, Ni and Pd and gives either the corresponding amino acids 33, 78 or 5-methyl-2-pyrrolidone derivatives 34 as a result of cyclodehydration, depending on whether the carboxy group of LA is protected or not. 79,80 The amides formed by the reaction of LA with various amines are attractive not only because of their biological activity, 81 but also because of their ability for cyclisation.…”
Section: Reactions Involving the Carbonyl Group 1 Reactions With N-nu...mentioning
confidence: 99%
“…For example, the carbonyl group of LA undergoes the Knoop ± Oesterlin reductive amination. 77 This reaction is catalysed by Co, Ni and Pd and gives either the corresponding amino acids 33, 78 or 5-methyl-2-pyrrolidone derivatives 34 as a result of cyclodehydration, depending on whether the carboxy group of LA is protected or not. 79,80 The amides formed by the reaction of LA with various amines are attractive not only because of their biological activity, 81 but also because of their ability for cyclisation.…”
Section: Reactions Involving the Carbonyl Group 1 Reactions With N-nu...mentioning
confidence: 99%
“…Enantiomerically pure (S)-Glu and its derivatives are very important physiologically active compounds (Huffman and Scelly 1963;Smith et al 2011). Although Glu itself is produced microbiologically and is a cheap industrial commodity (Huffman and Scelly 1963), its enantiomerically pure derivatives, in particular Gla, are not easily available.…”
Section: Introductionmentioning
confidence: 99%
“…Although Glu itself is produced microbiologically and is a cheap industrial commodity (Huffman and Scelly 1963), its enantiomerically pure derivatives, in particular Gla, are not easily available. This was a reason why the methods of asymmetric synthesis of Glu and its derivatives were sought.…”
Section: Introductionmentioning
confidence: 99%
“…Ethyl malonaldehydate (4.5 g) was added to the ammoniacal solution and stirred (45%); amino a c i d a n a l y s i s --o n l y a s p a r t i c a c i d d e t e c t e d , q u a n t i t a t i v e l y c o r r e c t ; NMR (DMSO, 19') 6 4.4 ( q , 1 H ) , 2.92 ( t , 2 H ) , no i m p u r i t i e s d e t e c t e d . [l-C ] g l u t a m i c a c i d (5) 13 13…”
mentioning
confidence: 99%