Glutamine-enriched enteral nutrition in very-low-birth-weight infants and effects on feeding tolerance and infectious morbidity: a randomized controlled trial

Berg, Anemone van den; Elburg, Ruurd M. van; Westerbeek, Elisabeth A. M.; Twisk, Jos W. R.; Fetter, W. P. F.

doi:10.1093/ajcn/81.6.1397

Cited by 87 publications

(90 citation statements)

References 30 publications

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“…All very preterm children (<32 wk of gestation) admitted to the level III neonatal intensive care unit of the VU University Medical Center Amsterdam between September 2001 and July 2003 were eligible for inclusion in a randomized controlled trial on the effects of glutamine supplementation (28). As we found some evidence that glutamine supplementation may have influenced brain development, only very preterm children of the control group of this trial were included in this study.…”

Section: Samplementioning

confidence: 99%

A crucial role for white matter alterations in interference control problems of very preterm children

et al. 2014

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Background: Attention problems are among the most prominent behavioral deficits reported in very preterm children (below 32 wk of gestation) at school age. In this study, we aimed to elucidate the brain abnormalities underlying attention problems in very preterm children by investigating the role of abnormalities in white and gray brain matter during interference control, using functional magnetic resonance imaging (fMRI)-guided probabilistic diffusion tensor tractography. Methods: Twenty-nine very preterm children (mean (SD) age: 8.6 (0.3) y), and 47 term controls (mean (SD) age: 8.7 (0.5) y), performed a fMRI version of the Eriksen Flanker task measuring interference control. results: Very preterm children showed slower reaction times than term controls when interfering stimuli were presented, indicating poorer interference control. Very preterm children and term controls did not differ in mean activation of the cortical regions involved in interference control. However, impaired fractional anisotropy (FA) was found in very preterm children in specifically those fiber tracts that innervate the cortical regions involved in interference control. Lower FA was related to poorer interference control in very preterm children. conclusion: White matter alterations have a crucial role in the interference control problems of very preterm children at school age. i mproved perinatal care has increased survival rates of very preterm (<32 wk of gestation) infants. However, large alterations in brain development remain present throughout childhood and adolescence (1), and surviving very preterm children appear to have pervasive behavioral problems more frequently than term peers (2,3). At school age, attention problems are among the most prominent behavioral deficits in very preterm children (4,5), having a detrimental impact on school performance and social functioning.One core aspect of attention is interference control, the ability to suppress distracters that might slow the primary response (6). The brain attention network involved in interference control has been widely investigated using functional magnetic resonance imaging (fMRI) tasks including the Eriksen Flanker task (7-9), suggesting involvement of the dorsal anterior cingulate cortex (dACC), inferior and lateral prefrontal cortices, and inferior parietal cortices.This study aims to elucidate brain abnormalities underpinning attention problems in very preterm children, by investigating the role of impairments in white and gray brain matter in interference control in very preterm children and term controls. First, we examined interference control problems and potential differences in cortical activation between very preterm children and term controls using the Eriksen Flanker task adapted for fMRI. Second, by using fMRI-guided probabilistic diffusion tensor tractography, we studied potential differences between very preterm children and term controls in white matter development using values of fractional anisotropy (FA) of specifically those fiber tracts that inne...

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Section: Samplementioning

confidence: 99%

A crucial role for white matter alterations in interference control problems of very preterm children

et al. 2014

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“…TPN'nin, ciddi malnütrisyonlu hastalarda özellikle enfeksiyon dışı komplikasyonları anlamlı olarak azalttığı görülmüştür. Bir meta-analizde, TPN'nin cerrahi hastalarda mortalite ve morbidite üzerine etkileri araştıran 27 adet randominize çalışma alınmıştır (29 (31,32).…”

Section: Discussionunclassified

The effects of perioperative total parenteral nutrition on postoperative mortality and morbidity

Baskonus¹,

Borazan²,

Maralcan³

et al. 2011

Gaziantep Med J

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ÖzetLiteratürde, ciddi malnütrisyonlu hastaların, ciddi malnütrisyonu olmayan hastalara göre postoperatif komplikasyon oranlarının daha yüksek olduğu bilinmektedir. Bu prospektif çalışmanın amacı; ciddi malnütrisyonlu gastrointestinal sistem kanserli hastalarda perioperatif beslenme tedavisinin, postoperatif morbidite ve mortalite üzerine etkilerinin araştırılmasıdır. Gastrointestinal sistem kanseri tanısı konulan 71 hasta çalışmaya alındı. Hastaların nütrisyonel durumunun değerlendirilmesi amacıyla Subjektif Global Değerlendirme indeksi kullanıldı. Hastalar ciddi malnütrisyonu olanlar (Grup 1) ve ciddi malnütrisyonu olmayanlar (Grup 2: hafif-orta malnütrisyonlular) şeklinde ikiye ayrıldı. Grup 1'deki 36 hastanın günlük enerji gereksinimleri hesaplandı, ortalama 30-35 kcal/kg/gün olacak şekilde preoperatif 7 gün ve postoperatif 3 gün total parenteral nütrisyon uygulandı. Grup 2'deki 35 hastaya perioperatif beslenme desteği yapılmadı. Morbidite ve mortalite takipleri hastaların hastanede yattıkları süre içerisinde yapıldı. Toplam morbidite: major, minor, total parenteral nütrisyona bağlı komplikasyonlar olarak değerlendirildi. Grup 1'de 7 hastada (%19.41), Grup 2'de 6 hastada (%17.11) majör komplikasyon görüldü (p=0.80). Toplam morbidite, Grup 1'de 16 (%44.40), Grup 2'de 17 (%48.57) olarak saptandı (p=0.727). Her iki grupta postoperatif dönemde birer adet mortalite görüldü. Bu çalışmada, ciddi malnütrisyonlu hastalarda perioperatif total parenteral nütrisyon tedavisi ile morbidite ve mortalitenin ciddi malnütrisyonu olmayan hastalardaki morbidite ve mortalite seviyesine kadar düşürülebileceği kanaatine varıldı. Anahtar kelimeler: Kanser; morbidite; mortalite; nütrisyonel değerlendirme; perioperatif nütrisyon Abstract It is known that postoperative complication ratios at severely malnourished patients were higher than nonseverely malnourished patients according to the data in literature reviews. The goal of this prospective study is to investigate the effects of perioperative nutritional support on postoperative morbidity and mortality in severely malnourished gastrointestinal tract cancer patients. Seventyone patients with the diagnosis of gastrointestinal tract cancer were included in this study. Subjective Global Assessment index was applied for patients' nutritional state. The patients were divided into two groups, severely malnourished (Group 1) and nonseverely malnourished (Group 2: well-nourished and mildly malnourished). The daily energy requirement of 36 patients in Group 1 was calculated and total parenteral nutrition was applied 30-35 kcal/kg/day by average for preoperative 7 days and postoperative 3 days to these 36 patients. Perioperative total parenteral nutrition was not given to 35 patients in Group 2. Patient morbidity and mortality was followed during the hospitalization period. Total morbidity was defined as; major complications, minor complications and complications related to total parenteral nutrition. Major complications occurred in 7 patients (19.41%) in Group 1 and 6 patients (17.11%) in G...

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“…Em outro estudo, o mesmo protocolo de suplementação foi utilizado (0,3 g de glutamina/kg/dia por 28 dias), entretanto, o grupo controle recebeu uma mistura isonitrogenada contendo alanina. Assim como no estudo de Neu et al (1997), a incidência de sepse no grupo de PT e com BPN que recebeu nutrição enteral suplementada com glutamina foi menor em relação ao controle (van den Berg et al, 2005) (Tabela II).…”

Section: Estudos Clínicos Com Suplementação Enteral Com Glutaminaunclassified

“…Conseqüentemente, a quantidade de glutamina fornecida pode ter sido insuficiente, devido ao rá-pido ganho de peso pós-natal. Além disso, similarmente aos estudos realizados por Van den Berg et al (2005) e Van den Berg et al (2006), parte dos bebês em ambos os grupos recebeu glutamina por meio do leite materno e, portanto, o grupo controle não foi privado de suprimento exógeno de glutamina. A concentração de glutamina no leite materno não foi dosada em nenhum dos estudos e, portanto, não é possível estimar a quantidade de glutamina ingerida pelo grupo controle.…”

Section: Estudos Clínicos Com Suplementação Enteral Com Glutaminaunclassified

“…A suplementação enteral com glutamina promoveu melhora da tolerância à dieta enteral em um dos estudos . No entanto, não tem sido observada melhora no crescimento físico, na diminuição da incidên-cia de EN ou no tempo de hospitalização em bebês suplementados com glutamina Vaughn et al, 2003;Van den Berg et al, 2005). Da mesma forma que os estudos envolvendo suplementação parenteral com glutamina, nenhum dos estudos realizados com suplementação enteral com glutamina observou toxicidade decorrente da suplementação Vaughn et al, 2003;Van den Berg et al, 2005;Van den Berg et al, 2006 …”

Section: Estudos Clínicos Com Suplementação Enteral Com Glutaminaunclassified

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Suplementação enteral e parenteral com glutamina em neonatos pré-termo e com baixo peso ao nascer

Borges¹,

Rogero²,

Tirapegui³

2008

Rev. Bras. Cienc. Farm.

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INTRODUÇÃOA glutamina é o aminoácido livre mais abundante no plasma e no tecido muscular, ao mesmo tempo em que apresenta diversas funções únicas no organismo, o que reforça seu papel relevante tanto em estados normais como fisiopatológicos (Figura 1) (Rogero et al., 2004). Este aminoácido é utilizado em altas taxas por células com elevado turnover, como enterócitos e leucócitos, para fornecer energia e favorecer a biossíntese de nucleotídeos, além de atuar tanto no anabolismo protéico, quanto na promoção do processo de adaptação e crescimento de tecidos altamente especializados Ball, Hardy, 2002).Dentre os órgãos envolvidos na síntese de glutamina, incluem-se o músculo esquelético, pulmões, fígado, cérebro e, possivelmente, o tecido adiposo, os quais contêm atividade

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Glutamine-enriched enteral nutrition in very-low-birth-weight infants and effects on feeding tolerance and infectious morbidity: a randomized controlled trial

Abstract: Glutamine-enriched enteral nutrition did not improve feeding tolerance or short-term outcome in VLBW infants. However, infectious morbidity was significantly lowered in infants who received glutamine-enriched enteral nutrition.

Cited by 87 publications

References 30 publications

A crucial role for white matter alterations in interference control problems of very preterm children

A crucial role for white matter alterations in interference control problems of very preterm children

The effects of perioperative total parenteral nutrition on postoperative mortality and morbidity

Suplementação enteral e parenteral com glutamina em neonatos pré-termo e com baixo peso ao nascer

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