Glutathione Concentration and Stability of the Red Blood Cells in Acute Childhood Leukemia

Haemoglobin H Disease in a Turkish Family

“…Erythrocyte glutathioae concentration in patients with Hb H disease, has been found normal or low, but stable after 2 h incubation with acetylphenylhydrazine (Rigas & Koler 1961, Scott et a1 1970. The red cell GSH was in the high normal range in this family (Ozsoylu 1970) and stable, perhaps reflecting the presence of young erythrocytes (Rigas & Koler 1961). The elevated G-6-PD activities of these patients is also indicative of the presence of young erythrocytes.…”

A Case of Hemolytic Anemia Due to Erythrocyte Pyrimidine 5′-Nucleotidase Deficiency

“…However, the elevated GSH level of the red cells of this patient needs an explan ation since GSH does not seem to be related to the age of the erythrocytes [5], Raised levels of erythrocyte GSH were found in different malignancies [5,8]] with decreased pyrimidine 5'-nucleotidase activity. Howev er, no correlation between the raised GSH levels and decreased enzyme activity was shown [8],…”

“…The symptoms of hemolysis include: reticulocytosis (12°/o), elevated serum bilirubin (to tal: 4.1 mg/dl; conjugated: 0.4 mg/dl) and plasma Hb (14.3 mg/100 ml; normal 5 mg/100 ml) [5]; ab sence of haptoglobin. Erythrocytic osmotic resist ance and autohemolysis were normal, as well as hemoglobin electrophoresis on starch (at pH 8.6 and 7) and agar (at pH 6.4); unstable hemoglobin was not found; Hb A2 was normal (3.2°/o) and Hb F slightly elevated (2.6°/o).…”