Glutathione (GSH) Peptide Conjugated Magnetic Nanoparticles As Blood–Brain Barrier Shuttle for MRI-Monitored Brain Delivery of Paclitaxel

Nosrati, Hamed; Tarantash, Mahsa; Bochani, Shayesteh; Charmi, Jalil; Bagheri, Zahra; Fridoni, Mohammadjavad; Abdollahifar, Mohammad‐Amin; Davaran, Soodabeh; Danafar, Hossein; Manjili, Hamidreza Kheiri

doi:10.1021/acsbiomaterials.8b01420

Cited by 56 publications

(23 citation statements)

References 31 publications

(45 reference statements)

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“…Also, utilization of certain ligands, such as transferrin, can benefit for targeted therapy and the penetration of biological barriers such as the BBB and cell membranes. 5 , 6 …”

Section: Introductionmentioning

confidence: 99%

Carbon Dots: A Future Blood–Brain Barrier Penetrating Nanomedicine and Drug Nanocarrier

Zhang

Sigdel

Mintz

et al. 2021

IJN

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Drug delivery across the blood–brain barrier (BBB) is one of the biggest challenges in modern medicine due to the BBB’s highly semipermeable property that limits most therapeutic agents of brain diseases to enter the central nervous system (CNS). In recent years, nanoparticles, especially carbon dots (CDs), exhibit many unprecedented applications for drug delivery. Several types of CDs and CD-ligand conjugates have been reported successfully penetrating the BBB, which shows a promising progress in the application of CD-based drug delivery system (DDS) for the treatment of CNS diseases. In this review, our discussion of CDs includes their classification, preparations, structures, properties, and applications for the treatment of neurodegenerative diseases, especially Alzheimer’s disease (AD) and brain tumor. Moreover, abundant functional groups on the surface, especially amine and carboxyl groups, allow CDs to conjugate with diverse drugs as versatile drug nanocarriers. In addition, structure of the BBB is briefly described, and mechanisms for transporting various molecules across the BBB and other biological barriers are elucidated. Most importantly, recent developments in drug delivery with CDs as BBB-penetrating nanodrugs and drug nanocarriers to target CNS diseases especially Alzheimer’s disease and brain tumor are summarized. Eventually, future prospects of the CD-based DDS are discussed in combination with the development of artificial intelligence and nanorobots.

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“…Also, utilization of certain ligands, such as transferrin, can benefit for targeted therapy and the penetration of biological barriers such as the BBB and cell membranes. 5 , 6 …”

Section: Introductionmentioning

confidence: 99%

Carbon Dots: A Future Blood–Brain Barrier Penetrating Nanomedicine and Drug Nanocarrier

Zhang

Sigdel

Mintz

et al. 2021

IJN

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“…The hemolytic activity of NPs was less than 3% at 10 mg ml −1 (Table ). Since samples with hemolytic activity of less than 3% are known as safe samples, Fe 3 O 4 @BSA‐MTX NPs are safe and applicable in the biomedical field. Photographs of HRBCs incubated with positive and negative controls and synthesized Fe 3 O 4 @BSA‐MTX NPs at concentrations of 1, 5 and 10 mg ml −1 are shown in Figure .…”

Section: Resultsmentioning

confidence: 99%

Simple surface functionalization of magnetic nanoparticles with methotrexate‐conjugated bovine serum albumin as a biocompatible drug delivery vehicle

Azizi

Nosrati

Danafar

2020

Applied Organom Chemis

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Magnetic nanoparticles (MNPs) functionalized with methotrexate (MTX)‐conjugated bovine serum albumin (BSA) as a biocompatible drug delivery vehicle were synthesized using a facile method. Characterization of the functionalized MNPs (Fe3O4@BSA‐MTX NPs) was performed using various techniques including UV–visible spectroscopy, dynamic light scattering, vibrating sample magnetometry and X‐ray diffraction. The particle size and zeta potential of Fe3O4@BSA‐MTX NPs were 105.7 ± 3.81 nm (mean ± SD) and −18.2 mV, respectively. MTX release from Fe3O4@BSA‐MTX NPs showed an enzyme‐dependent release pattern. Hemo‐biocompatibility of Fe3O4@BSA‐MTX NPs was confirmed using hemolysis test. In addition, the cytotoxicity of functionalized MNPs and free MTX against MCF‐7 cell line was investigated using MTT assay. The results of experiments revealed that the Fe3O4@BSA‐MTX NPs as a biocompatible carrier could improve the therapeutic effect of MTX.

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“…Nosrati et al (2019) reported the use for glutathione (GSH) decorated iron NPs (GSHIONPs) for brain drug delivery. IONPs@Asp-PTX-PEG-GSH are stable, non-toxic and enhance MRI contrast for diagnostic purpose [111].…”

Section: Metallic Npsmentioning

confidence: 99%

Peptide based drug delivery systems to the brain

Islam

Leach

Smith³

et al. 2020

Nano Express

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With estimated worldwide cost over $1 trillion just for dementia, diseases of the central nervous system pose a major problem to health and healthcare systems, with significant socio-economic implications for sufferers and society at large. In the last two decades, numerous strategies and technologies have been developed and adapted to achieve drug penetration into the brain, evolving alongside our understanding of the physiological barriers between the brain and surrounding tissues. The blood brain barrier (BBB) has been known as the major barrier for drug delivery to the brain. Both invasive and minimally-invasive approaches have been investigated extensively, with the minimallyinvasive approaches to drug delivery being more suitable. Peptide based brain targeting has been explored extensively in the last two decades. In this review paper, we focused on self-assembled peptides, shuttle peptides and nanoparticles drug delivery systems decorated/conjugated with peptides for brain penetration.Abbreviations

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Glutathione (GSH) Peptide Conjugated Magnetic Nanoparticles As Blood–Brain Barrier Shuttle for MRI-Monitored Brain Delivery of Paclitaxel

Cited by 56 publications

References 31 publications

Carbon Dots: A Future Blood–Brain Barrier Penetrating Nanomedicine and Drug Nanocarrier

Carbon Dots: A Future Blood–Brain Barrier Penetrating Nanomedicine and Drug Nanocarrier

Simple surface functionalization of magnetic nanoparticles with methotrexate‐conjugated bovine serum albumin as a biocompatible drug delivery vehicle

Peptide based drug delivery systems to the brain

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