Glutathione‐Responsive Heterogeneous Metal–Organic Framework Hybrids for Photodynamic‐Gene Synergetic Cell Apoptosis

Biomolecules meet organic frameworks: from synthesis strategies to diverse applications

“…Through effective resonance energy transfer (RET) of Nd 3+ sensitized upconversions to the nMOF domains, UCMT allows the generation of reactive oxygen species (ROS) under 808 near-infrared light activation. Furthermore, Liu et al 78 reported a BOF for intelligent glutathione (GSH) imaging while simultaneously reducing GSH levels. The BOF consisted of a photoactive MOF as the core and susceptible ZIF-67(Cu) as the shell with the installation of additional cyanine 3-labeled siRNA.…”

Surface functionalization of metal–organic framework nanoparticle for overcoming biological barrier in cancer therapy

“…Beyond reflecting the metabolic adaptations of cancer cells, this acidic microenvironment plays a pivotal role in shaping the behavior of both malignant and stromal cells within the TME. 56 GSH has emerged as a key contributor influencing redox balance, cellular signaling, and therapeutic responses within the TME. GSH, a tripeptide composed of glutamate, cysteine, and glycine, is the principal antioxidant that maintains cellular redox homeostasis.…”

Metal‐Organic Frameworks Nanocarriers for Functional Nucleic Acid Delivery in Biomedical Applications

“…Recently, Liu et al reported the glutathione (GSH) responsive core-shell MOFs hybrids of porous coordination network (PCN) and siRNA-encapsulated ZIF-67 shells. [33] The core photosensitizer PCN was released after dissociation of ZIF-67 by the intracellular high concentration of GSH. siRNAs have become indispensable tools for validating gene function and are widely explored for cancer therapy.…”