Glutathione S-transferase P1 Ile105Val polymorphism, cigarette smoking and prostate cancer

Mao, Gloria E.; Morris, G.M.; Lu, Qing-Yi; Cao, Wei; Reuter, Victor E.; Cordon‐Cardo, Carlos; Dalbagni, Guido; Scher, Howard I.; deKernion, Jean B.; Zhang, Zuo‐Feng

doi:10.1016/j.cdp.2004.07.003

Cited by 39 publications

(28 citation statements)

References 36 publications

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“…They found that in individuals with the Ile/Ile genotype, smoking was strongly associated with an increased risk of PCa. 39,40 Two further case-control studies reported no association between GSTP1 and PCa risk. 25,37 Association of the GSTP1 Val allele with PCa could be expected as the conversion of the amino acid at codon 105 from isoleucine to valine substantially diminishes activity of the altered enzyme.…”

Section: Discussionmentioning

confidence: 99%

Glutathione S-transferase gene polymorphisms (GSTM1, GSTT1, GSTP1) and prostate cancer: a case-control study in Tehran, Iran

Safarinejad¹,

Shafiei²,

Safarinejad³

2011

Prostate Cancer Prostatic Dis

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We evaluated the relationship between polymorphisms in the glutathione S-transferases (GSTs) GSTM1, GSTT1 and GSTP1 genes and prostate cancer (PCa). PCR-restriction fragment length polymorphism assay was used to genotype the GSTM1, GSTT1, and GSTP1 polymorphisms in 168 PCa cases and 336 frequency matched controls. The GSTM1 null, and GSTT1 null genotypes were associated with an increased odds ratio (OR) for PCa (OR ¼ 3.28, 95% confidence interval (CI): 2.47-5.64; P ¼ 0.005, and OR ¼ 3.21, 95% CI: 2.52-5.64; P ¼ 0.005, respectively) (Pcorrected ¼ 0.0062). The frequency of GSTP1 Val/Val genotype was 14.3% in cases compared with 2.4% in controls, this polymorphism thus being associated with a significantly increased risk of PCa (OR ¼ 3.72, 95% CI: 1.67-5.65; P ¼ 0.002). The risk associated with the concurrent absence of both of the genes (OR ¼ 4.8, 95% CI: 2.34-6.78) was greater than the product of risk in men with either null (OR ¼ 1.52, 95% CI: 0.82-2.31) genotype combinations (P ¼ 0.001, Pcorrected ¼ 0.0045). The combination of GSTP1 Ile/Val or Val/Val polymorphism with the GSTT1 null and GSTM1 null type resulted in an OR of 6.21 (95% CI: 4.83-16.87) (P ¼ 0.0001, Pcorrected ¼ 0.0062). A higher frequency of the GSTM1 null genotype and GSTT1 null genotype was observed in patients with Gleason score 47, with an OR for GSTM1 null 4.67 (95% CI: 3.64-7.62; P ¼ 0.001) and with an OR for GSTT1 null 3.62 (95% CI: 2.31-5.74; P ¼ 0.004). The results obtained demonstrated that simultaneous presence of three potentially risk alleles (GSTM1 null, GSTT1 null and GSTP1 Val) lead to a significant OR increase for PCa.

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Section: Discussionmentioning

confidence: 99%

Glutathione S-transferase gene polymorphisms (GSTM1, GSTT1, GSTP1) and prostate cancer: a case-control study in Tehran, Iran

Safarinejad¹,

Shafiei²,

Safarinejad³

2011

Prostate Cancer Prostatic Dis

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“…For instance, recent prostate cancer case-control studies have shown a gene by smoking interaction for variants in the GSTM1 [5], GSTT1 [6] and GSTP1 [7] genes. Effects of variation of GSTP1 on prostate cancer risk may also be enhanced when considering other conjugation genes, such as GSTM1 and GSTT1, in tandem [22].…”

Section: Discussionmentioning

confidence: 99%

“…A strong family history indicative of a highly penetrant prostate cancer gene is believed to account for only 5-10% of cases, but a larger percentage of prostate cancers may be due to common polymorphisms in genes giving rise to a low penetrance risk of disease [2][3][4]. The effect of polymorphisms in metabolic or DNA repair pathways on disease risk may be dependent upon the exposures that are part of these pathways [5][6][7].…”

Section: Introductionmentioning

confidence: 99%

Prostate cancer risk from occupational exposure to polycyclic aromatic hydrocarbons interacting with the GSTP1 Ile105Val polymorphism

Rybicki

Neslund‐Dudas

Nock

et al. 2006

Cancer Detection and Prevention

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Condensed Abstract-Men who carry the GSTP1 Val 105 variant who are exposed at high levels to occupational PAH are at increased risk for prostate cancer. This increased risk is more pronounced in men under age 60 or with a family history of prostate cancer.Background-Variation in the glutathione S-transferase (GSTP1) gene and occupational polycyclic aromatic hydrocarbons (PAH) exposure are putative prostate cancer risk factors. An Ile/ Val polymorphism in codon 105 of GSTP1 affects its enzymatic activity toward PAH detoxification, a possible mechanism in prostate carcinogenesis.

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“…The effect of B(a)P on DNA polymorphism has been previously discussed (Wang et al, 2003). This DNA polymorphism occurred in different genes as P53, K-ras and glutathione S-transferase (Mao et al, 2004).…”

Section: Restriction Fragments Length Polymorphism (Rflp)mentioning

confidence: 96%

Protective Effect of Curcumin and Chlorophyllin against DNA Mutation Induced by Cyclophosphamide or Benzo[a]pyrene

Ibrahim

El-Behairy

Ghoneim

et al. 2007

Zeitschrift Für Naturforschung C

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The current study was carried out to evaluate the potency of curcumin and chlorophyllin as natural antioxidants to reduce the oxidative stress markers induced by cyclophosphamide (CP) and benzo [a]pyrene [B(a)P] which were used as free radical inducers.For this purpose, 126 male albino rats were used. The animals were assigned into 4 main groups: negative control group; oxidant-treated group (subdivided into two subgroups: cyclophosphamide-treated group and benzo[a]pyrene-treated group); curcumin-treated group; and chlorophyllin-treated group. Liver samples were collected after two days post the oxidant inoculation and at the end of the experimental period (10 weeks). These samples were examined for determination of liver microsomal malondialdehyde (MDA), DNA fragmentation, restriction fragment length polymorphism (RFLP) and 8-hydroxy deoxyguanosine (8-OHdG) concentration.Both CP and B(a)P caused increments in DNA fragmentation percentages, liver microsomal MDA, concentration of 8-OHdG and induced point mutation. Treatment of rats with either curcumin or chlorophyllin revealed lower DNA fragmentation percentages, liver microsomal MDA concentration, concentration of 8-OHdG and prevented induction of mutations, i. e., reversed the oxidative stress induced by CP and B(a)P and proved that they were capable of protecting rats against the oxidative damage evoked by these oxidants.

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Glutathione S-transferase P1 Ile105Val polymorphism, cigarette smoking and prostate cancer

Cited by 39 publications

References 36 publications

Glutathione S-transferase gene polymorphisms (GSTM1, GSTT1, GSTP1) and prostate cancer: a case-control study in Tehran, Iran

Glutathione S-transferase gene polymorphisms (GSTM1, GSTT1, GSTP1) and prostate cancer: a case-control study in Tehran, Iran

Prostate cancer risk from occupational exposure to polycyclic aromatic hydrocarbons interacting with the GSTP1 Ile105Val polymorphism

Protective Effect of Curcumin and Chlorophyllin against DNA Mutation Induced by Cyclophosphamide or Benzo[a]pyrene

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