Glutathione S-Transferase T1 and M1 Polymorphisms and Risk of Uterine Cervical Lesions in Women from Central Serbia

Stošić, Ivana; Grujičić, Darko; Arsenijevic, Slobodan; Brkić, Marija; Milošević-Djordjević, Olivera

doi:10.7314/apjcp.2014.15.7.3201

Cited by 16 publications

(15 citation statements)

References 27 publications

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“…Contribution of the GSTM1-null to the development of various types of cancer has been documented with controversial conclusions (Duell et al, 2002;Roodi et al, 2004;Tiwawech et al, 2005;Liu et al, 2014;Stosic et al, 2014). Our present study identifying GSTM1 genotypes in the age matched case-control study could not find the effect of GSTM1 polymorphism on cervical carcinogenesis; the result rejects the association between genetic polymorphism of GSTM1 and increased risk for cervical cancer (Table 2).…”

Section: Discussioncontrasting

confidence: 73%

“…This genotyping study confirmed our previous report on the GSTM1-null and cervical cancer (Settheetham-Ishida et al, 2009) and agreed with the previous finding in Caucasian (Chen et al, 1999), Japanese (Niwa et al, 2005), Indian ( Sobti et al, 2006, Singh et al, 2008, Sicilian (Agodi et al, 2010) and Italian ( Palma et al, 2010) women. In contrast, an association between the GSTM1 polymorphism and increased risk of cervical cancer was observed in central Serbia and suggested a possible important role of the GSTM1 deletion in the development of early stage of precancerous lesions (Stosic et al, 2014). Furthermore, a meta-analysis found GSTM1-null genotype showed an increased risk of uterine cervical lesions in Chinese and Indian but no risk for Japanese, European and American (Gao et al, 2011;Zhang et al, 2012).…”

Section: Discussionmentioning

confidence: 93%

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Lack of Participation of the GSTM1 Polymorphism in Cervical Cancer Development in Northeast Thailand

Natphopsuk¹,

Settheetham-Ishida²,

Settheetham³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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The potential association between the GSTM1 deletion polymorphism and risk of cervical cancer was investigated in Northeastern Thailand. DNA was extracted from buffy coat specimens of 198 patients with squamous cell carcinoma of the cervix and 198 age-matched healthy controls. Genotyping of the GSTM1 was conducted by using two PCR methods, a short-and a long-PCR. Distribution of the GSTM1 genotypes in between the cases and the controls was not significantly different (p>0.5 by χ 2 test). The results suggest that the GSTM1 deletion polymorphism is not a risk factor for squamous cell carcinoma of the cervix in the northeast Thai women.

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Section: Discussioncontrasting

confidence: 73%

Section: Discussionmentioning

confidence: 93%

Lack of Participation of the GSTM1 Polymorphism in Cervical Cancer Development in Northeast Thailand

Natphopsuk¹,

Settheetham-Ishida²,

Settheetham³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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“…21 studies of GSTM1 polymorphisms (2,250 CC cases and 3,025 controls) [6,8,[10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28] , 17 studies of GSTT1 polymorphisms (1,704 CC cases and 2,060 controls) genotypes [6, 11-13, 15-17, 20-24, 26-30] , and 9 studies of GSTM1-GSTT1 interaction analyses (1,046 CC cases and 1,319 controls) [6,11,12,15,16,24,26,28] were included in our meta-analysis. The characteristics of the studies are summarized in Table 1.…”

Section: Resultsmentioning

confidence: 99%

An Updated Meta-Analysis: Cervical Cancer Risk Conferred by GSTM1 and GSTT1 Polymorphisms

Liu¹,

Zeng²,

Ma³

et al. 2017

ijSciences

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Objective: To study the influence of GSTM1 and GSTT1 gene polymorphisms on cervical cancer (CC) risk, and explore genetic-environmental interactions. Methods: After a systematic literature search, all relevant studies entailing the association between GST polymorphisms and CC were included. The pooled odds ratio (OR) was used for analysis of the results and corresponding 95% confidence intervals (CI) were estimated. Results: A total of 23 case-control studies were included in the meta-analysis of GSTM1 (2,250 CC cases and 3,025 controls) and GSTT1 (1,704 CC cases and 2,460 controls) genotypes. For the GSTM1 polymorphisms, the null genotype of GSTM1 was associated with an increased CC risk for the total population (OR=1.57, 95% CI=1.25-1.98). A similar association was found in China (OR=2.34, 95% CI=1.56-3.52), India (OR=2.02, 95% CI=1.43-2.83), Pakistan (OR=5.52, 95% CI=2.34-13.07), Serbia (OR=1.73, 95% CI=0.68-4.39) and Kazakhstan (OR=6.5, 95%CI=2.25-18.81), but was not noted for others countries. Regarding human papilloma virus (HPV) infection, moderately but significantly increased risk of the null GSTM1 genotype was found in HPV-positive patients (OR=2.59, 95% CI=1.57-4.27). For the GSTT1 polymorphisms, the null GSTT1 genotype was associated with increased CC risk in the total population (OR=1.44, 95% CI=1.07-1.93). Regarding ethnic stratification, a significantly increased risk of the null GSTT1 genotype was found in Kazakhstan (OR=3.99, and Brazil (OR=4.58, 95% CI=2.04-10.28). With respect to smoking, the two aspects of the analysis above were not significantly associated with CC risk in smokers or non-smokers, respectively. For the GSTM1/GSTT1 interaction analysis, the dual null genotypes of GSTM1/GSTT1 were significantly associated with increased CC risk for the total population (OR=1.62, 95% CI=1.14-2.29). Conclusion: This meta-analysis provided sufficient evidence that the null genotype of GSTM1, or GSTT1 and the dual-null genotypes of GSTM1/GSTT1 are associated with CC.

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“…Studies performed in different countries such as India (Joseph et al, 2006), Italy (Palma et al, 2010) and Kasakhstan (Djangusurova et al, 2013), considered the GSTM1 and GSTT1 null polymorphism as a risk factor for cervical cancer. On the other hand, studies in countries such as Thailand (Ishida et al, 2009), Turkey (Kiran et al, 2010) and Serbia (Stosic et al, 2014), did not consider GSTM1 and GSTT1 null polymorphism as a risk factor for cervical cancer. In a study in Colombia (Sierra-Torres et al, 2006), the GSTM1 and GSTT1 null polymorphisms did not affect the risk for high grade intraepithelial lesions, suggesting other factors as more important for cancer evolution, such as high grade infection by HPV, exposition to mutagenic compounds and polymorphisms in other metabolism genes, such as CYP2E1.…”

Section: Discussionmentioning

confidence: 99%

Research Article Null polymorphisms in <i>GSTT1</i> and <i>GSTM1</i> genes and their associations with smoking and cervical cancer

Tacca¹,

Lopes²,

Vilanova-Costa³

et al. 2019

Genet. Mol. Res.

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Human papillomavirus (HPV) infection is the main risk factor for cervical cancer. Other risk factors include smoking and genetic susceptibility. Glutathione-S-transferases (GST) are enzymes involved in tobacco carcinogen metabolism, and genes encoding these enzymes are highly polymorphic. We compared the frequencies of GSTM1 and GSTT1 null polymorphisms in women with cervical cancer and in a control group, as well as to determine possible associations between such polymorphisms, cigarette smoking and the prognosis of cervical cancer. The series comprised 135 cervical cancer patients and 100 women without cancer. Genotypes were ©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 18 (1): gmr18067 A.L.M. Tacca et al. 2 investigated by PCR. The results were compared using the Chisquare test or Fisher's exact test, and survival analysis by Kaplan-Meier test and Log-rank. Among the cases, the frequency of GSTM1 gene null polymorphism was 22.2%, and for the GSTT1 gene it was 48.5%. Among the controls, the frequency of the GSTM1 gene null polymorphism was 45.0%, while for GSTT1 it was 56.0%. A significant association was found between smoking and cervical cancer (P= 0.0062; OR = 2.16). Differently from GSTM1, the GSTT1 null polymorphism was not associated with cervical cancer risk in this study. The GSTT1 null genotype was significantly associated with worse prognosis. The overall survival rate for the cervical cancer group was 78.5%, and when stratified by genotypes, survival was higher in patients presenting at least one of the alleles, GSTT1 or GSTM1, indicating a higher risk of death for those presenting dual nullity (P= 0.031; RR = 2.458).

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Glutathione S-Transferase T1 and M1 Polymorphisms and Risk of Uterine Cervical Lesions in Women from Central Serbia

Cited by 16 publications

References 27 publications

Lack of Participation of the GSTM1 Polymorphism in Cervical Cancer Development in Northeast Thailand

Lack of Participation of the GSTM1 Polymorphism in Cervical Cancer Development in Northeast Thailand

An Updated Meta-Analysis: Cervical Cancer Risk Conferred by GSTM1 and GSTT1 Polymorphisms

Research Article Null polymorphisms in <i>GSTT1</i> and <i>GSTM1</i> genes and their associations with smoking and cervical cancer

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