Gluten and skin disease beyond dermatitis herpetiformis: a review

Muddasani, Suraj; Rusk, Amanda M.; Nole, Katherine L Baquerizo

doi:10.1111/ijd.15098

Cited by 12 publications

(9 citation statements)

References 47 publications

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“…Among CTD, dermatomyositis, a rare autoimmune disease which typically affects the skin, the muscles, and the blood vessels, is the most common CTD described in association with CD [ 23 , 24 , 25 , 26 ]. In patients with coexisting CD and DM, a GFD may improve the cutaneous signs of DM [ 27 ].…”

Section: Review: CD Association With Connective Tissue Diseases and C...mentioning

confidence: 99%

Cutaneous Disorders Masking Celiac Disease: Case Report and Mini Review with Proposal for a Practical Clinical Approach

Ancona,

Bianchin,

Zampatti

et al. 2023

Nutrients

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Celiac disease (CD) is an immune-mediated systemic gluten-related disorder characterized by a wide spectrum of intestinal and extra-intestinal manifestations, including damage to cutaneous and connective tissue. We report a rare case of chronic severe dermatitis involving connective tissue and cutaneous vascular vessels as the main clinical presentation of undiagnosed seronegative gluten disorder. A gluten-free diet dramatically improved the intestinal and cutaneous clinical damage in the patient. Pitfalls and the steps of differential diagnosis are described. We also review the literature regarding studies of CD and connective tissue diseases to extend the knowledge of these rare associations. We propose a practical diagnostic approach in suspected CD in autoimmune cutaneous disorders.

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Section: Review: CD Association With Connective Tissue Diseases and C...mentioning

confidence: 99%

Cutaneous Disorders Masking Celiac Disease: Case Report and Mini Review with Proposal for a Practical Clinical Approach

Ancona,

Bianchin,

Zampatti

et al. 2023

Nutrients

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“…These lesions are accompanied by intense itching of the skin [2,4,[10][11][12][13][14]. DH occurs with an asymptomatic sensitivity to gluten that is contained in wheat, oats, barley, and rye grains [1,3,6,[14][15][16].…”

Section: Introductionmentioning

confidence: 99%

“…Deposition of IgG, IgM and C3 may also occur [1,2,4,6,[10][11][12][13][21][22][23][24][25]. Histopathological examination of a small bowel specimen shows varying degrees of villous atrophy and lymphocytic infiltration [2,6,13,16,25].…”

Section: Introductionmentioning

confidence: 99%

Immunopathological Assessment of the Oral Mucosa in Dermatitis Herpetiformis

Mania-Końsko

Szponar

Dańczak‐Pazdrowska

et al. 2023

IJERPH

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Dermatitis herpetiformis (Duhring’s disease, DH) is a chronic blistering cutaneous condition with pruritic polymorphic lesions, consisting of vesicles, papules or nodules and erythema, found predominantly on the extensor surfaces of the limbs, buttocks, and neck. Diagnosis is based on characteristic clinical and immunopathological findings. Oral manifestations of DH have rarely been described. The aim of the study was to evaluate IgA, IgG, IgM and C3 complement deposits in the oral mucosa in DH patients. Direct immunofluorescence (DIF) was performed on the oral mucosa specimens collected from 10 DH patients. Biopsy was taken in a local anesthesia from perilesional site from the buccal mucosa and then preserved in a standard procedure using polyclonal rabbit IgG, IgA, IgM and C3 antibodies. Granular IgA and C3 deposits were found in 6 patients (60%), and in 3 subjects (30%) the result was indeterminate. Significant fluorescence of the deposits along the basement membrane was observed in 2 patients, moderate fluorescence in 3 patients, and in 4 cases the result was indeterminate. C3 deposits were found in 5 subjects (50%), 3 of them being moderate and 2 indeterminate. No IgM and IgG deposits were detected in the collected buccal mucosa specimens.

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“…Other dermatologic diseases associated with CD include psoriasis, palmoplantar pustulosis, urticaria, rosacea, atopic dermatitis, and aphthous stomatitis, as well as several others with less supporting evidence. [3][4][5] The risk of developing skin disorders is highest within the first year of CD diagnosis and may persist beyond 10 years 1 ; however, patients may experience skin symptoms in the absence of gastrointestinal symptoms. For example, up to one-third of patients with DH exhibit symptoms at the time of CD diagnosis.…”

mentioning

confidence: 99%

“…2 While rare, there are reported cases of otherwise asymptomatic CD presenting with palmoplantar pustulosis, aphthous stomatitis, and dermatomyositis that have resolved with gluten-free diet. 4,5 While several, well-described cutaneous eruptions have been reported with CD, the prevalence of both preceding chronic dermatoses and asymptomatic, nonspecific eruptions is unknown, particularly among those without gastroenterological symptoms. This may be due to underreporting of such rashes and/or underdiagnosis of CD.…”

mentioning

confidence: 99%