Gluten-free diet does not influence the occurrence and the Th1/Th17-Th2 nature of immune-mediated diseases in patients with coeliac disease

Imperatore, Nicola; Rispo, Antonio; Capone, P.; Donetto, Sara; Palma, Giovanni Domenico De; Gerbino, N.; Rea, Matilde; Caporaso, N.; Tortora, Raffaella

doi:10.1016/j.dld.2016.03.026

Cited by 14 publications

(15 citation statements)

References 46 publications

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“…In our study, patients who continued on GCD had a statistically significant higher risk of developing CD-related IMD than patients who were placed on GFD (61% vs 18%, p=0.03, OR=3.3). Although the GFD does not prevent the occurrence of IMD [22], in this population the early onset of treatment could reduce the incidence, or at least delay the occurrence, of autoimmune diseases. In our opinion, our findings, along with those in the literature mentioned above, suggest that all PCD patients should start an early dietetic treatment, regardless of the presence or absence of symptoms.…”

Section: Discussionmentioning

confidence: 91%

Beneficial effects of gluten free diet in potential coeliac disease in adult population

Imperatore¹,

Tortora²,

Palma³

et al. 2017

Digestive and Liver Disease

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Section: Discussionmentioning

confidence: 91%

Beneficial effects of gluten free diet in potential coeliac disease in adult population

Imperatore¹,

Tortora²,

Palma³

et al. 2017

Digestive and Liver Disease

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“…7 Thus, there seems to be a link between the amount of gluten intake in infancy and CD and T1DM development. [8][9][10] Other environmental exposures, such as reovirus and enterovirus infections, may trigger the development of CD, 11,12 and viral gastroenteritis has also been observed to increase the odds of developing IBD, which has significant comorbidity with CD. 13 In fact, the risk of developing IBD is greater not only in first degree relatives of CD patients but also in their spouses, indicating a mix of genetic and environmental factors predisposing to IMCs.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of coexisting autoimmune thyroidal diseases in coeliac disease is decreasing

et al. 2020

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Background Coeliac disease (CD) is associated with an increased risk of other immune-mediated conditions. Aim: To investigate the prevalence of coexistent immune-mediated diseases in CD patients, and changes in the prevalence of autoimmune thyroidal diseases over the last 50 years. Methods Medical record data were collected retrospectively from 749 CD patients in Ireland. Prevalence of autoimmune diseases was compared with previously published results from general populations. Patients were divided into four groups based on the year of diagnosis to analyse changes in the prevalence of autoimmune thyroidal disease over time. Results Median age at the time of CD diagnosis was 56 years (range 18–91 years). A total of 233 (31.1%) patients had a coexistent immune-mediated condition (IMC). Autoimmune thyroidal diseases were seen in 149 (19.9%) patients, hypothyroidism in 110 (14.7%), type 1 diabetes in 27 (3.6%), psoriasis in 20 (2.7%), inflammatory bowel disease in 14 (1.9%) and rheumatoid arthritis in 12 (1.6%). All conditions were more common in CD patients than in the general population. Type 1 diabetes was diagnosed mainly before CD, whereas there was no such trend in other conditions. Autoimmune thyroidal diseases became less common in female CD patients over time. Conclusions Prevalence of autoimmune diseases is increased in adult CD patients compared with the general population. However, concomitant autoimmune thyroidal diseases became less common over time in women.

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“…11 It is interesting that a recent study showed that the prevalence of other immune-mediated disorders was high at CD diagnosis (20%) and increased during follow-up with more than half of the patients developing new immune-mediated diseases despite a GFD. 33 Splenic dysfunction can also lead to reduced platelet sequestration and defective removal of pits from erythrocytes. The first might induce thromboembolism, the latter an increase of circulating Howell-Jolly bodies and pitted red cells.…”

Section: Discussionmentioning

confidence: 99%

Splenic volume differentiates complicated and non‐complicated celiac disease

et al. 2017

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Background: Studies in small groups of patients indicated that splenic volume (SV) may be decreased in patients with celiac disease (CD), refractory CD (RCD) type II and enteropathy-associated T-cell lymphoma (EATL). Objective: The objective of this article is to evaluate SV in a large cohort of uncomplicated CD, RCD II and EATL patients and healthy controls. Methods: The retrospective cohort consisted of 77 uncomplicated CD (of whom 39 in remission), 29 RCD II, 24 EATL and 12 patients with both RCD II and EATL. The control group included 149 healthy living kidney donors. SV was determined on computed tomography. Results: The median SV in the uncomplicated CD group was significantly larger than in controls (202 cm 3 (interquartile range (IQR): 154-275) versus 183 cm 3 (IQR: 140-232), p ¼ 0.02). After correction for body surface area, age and gender, the ratio of SV in uncomplicated CD versus controls was 1.28 (95% confidence interval: 1.20-1.36; p < 0.001). The median SV in RCD II patients (118 cm 3 (IQR 83-181)) was smaller than the median SV in the control group (p < 0.001). Conclusion: This study demonstrates large inter-individual variation in SV. SV is enlarged in uncomplicated CD. The small SV in RCD II may be of clinical relevance considering the immune-compromised status of these patients.

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Gluten-free diet does not influence the occurrence and the Th1/Th17-Th2 nature of immune-mediated diseases in patients with coeliac disease

Cited by 14 publications

References 46 publications

Beneficial effects of gluten free diet in potential coeliac disease in adult population

Beneficial effects of gluten free diet in potential coeliac disease in adult population

Prevalence of coexisting autoimmune thyroidal diseases in coeliac disease is decreasing

Splenic volume differentiates complicated and non‐complicated celiac disease

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