Gluten-free diet may alleviate depressive and behavioural symptoms in adolescents with coeliac disease: a prospective follow-up case-series study

Pynnönen, Päivi; Isometsä, Erkki; Verkasalo, M; Kähkönen, Seppo; Sipilä, Ilkka; Savilahti, Erkki; Aalberg, Veikko

doi:10.1186/1471-244x-5-14

Cited by 86 publications

(76 citation statements)

References 33 publications

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“…Therefore, we investigated whether the depression and anxiety levels differed between the dietary compliant and non-compliant patients, but no differences were observed. Some studies have reported that a gluten-free diet has no effect on the development of anxiety and depression in CD children and adolescents (5,22). The results of the questionnaires for STAI-I, STAI-II, and BDI, which had been given to the mothers of the CD group participants (i.e., dietary compliant and non-compliant), showed that although there were no between-group differences in terms of the indicators of depression, anxiety was more evident in the gluten-free diet non-compliant group.…”

Section: Esenyel Et Al the Mental Health Of Coeliac Childrenmentioning

confidence: 99%

“…Psychiatric problems have been reported in 21% of CD patients who have not started dietary treatment with a gluten-free diet (4). In a study of adolescents by Pynnonen et al (5), symptoms of depressive disorders had been observed prior to an established diagnosis of CD, and the patients were reported to be completely asymptomatic after undergoing treatment with a gluten-free diet.…”

Section: Introductionmentioning

confidence: 99%

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Depression and anxiety in child and adolescents with follow-up celiac disease and in their families

Esenyel

Ünal²,

Vural³

2014

Turk J Gastroenterol

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Background/Aims: Earlier research has indicated a positive association between Celiac disease and some mental disorders in both adults and children. The aim of this study was to explore the diet compliance and depression and anxiety levels of pediatric celiac children and their families after a gluten-free diet. Materials and Methods: A total of 30 celiac pediatric patients (17 children [57%] and 13 adolescents [43%]) were enrolled in the study, and 20 healthy controls (11 children [55%] and 9 adolescents [45%]) were studied as controls. Depression was assessed with the Children's Depression Inventory (CDI) form, and anxiety was assessed with the Screen for Child Anxiety Related Disorders (SCARED) form. Diet compliance was measured with a diet compliance form, and the families were asked to complete the Beck Depression Measurement (BDI) form for depression and the State-Trait Anxiety Inventory I-II (STAI-I and STAI-II) forms for anxiety. Results: There was no significant difference in depression and anxiety between pediatric celiac patients consuming a gluten-free diet and the healthy control group. We observed no difference in depression and anxiety in the Celiac CD group patients. Diet compliance was 73.3% in the study group. Conclusion: The depression and anxiety levels of pediatric celiac patients and their parents did not differ from those in the healthy group.

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Section: Esenyel Et Al the Mental Health Of Coeliac Childrenmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Depression and anxiety in child and adolescents with follow-up celiac disease and in their families

Esenyel

Ünal²,

Vural³

2014

Turk J Gastroenterol

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“…In older children the clinical picture is often not specific, with abdominal pain or extraintestinal manifestations, growth retardation, isolated anemia, and behavioral symptoms. [2][3][4] Because the clinical features of CD may not always be evident, a substantial proportion of patients will not be identified through symptom-based case finding. 5,6 The cornerstones of CD diagnosis include presence of clinical signs and symptoms, seropositivity for endomysial or tissue transglutaminase autoantibodies (tTGA), carrying any of the HLA risk haplotypes DR3-DQ2 or DR4-DQ8, and showing typical histologic features in intestinal biopsies, characterized by villous atrophy and crypt hyperplasia with elevated intraepithelial lymphocytes.…”

Section: What This Study Addsmentioning

confidence: 99%

Clinical Features of Celiac Disease: A Prospective Birth Cohort

et al. 2015

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To investigate clinical features of celiac disease (CD) and their association with risk factors for CD in a genetic risk birth cohort.METHODS: Children from 6 clinical centers in 4 countries positive for HLA-DR3-DQ2 or DR4-DQ8 were annually screened for tissue transglutaminase antibodies (tTGA) and assessed for symptoms by questionnaires. Associations of symptoms with anthropometrics, known risk factors for CD, tTGA levels, and mucosal lesions in those biopsied were examined.RESULTS: Of 6706 screened children, 914 developed persistent positive tTGA, 406 underwent biopsies, and 340 had CD. Compared with age-matched tTGA-negative children, those with persistent tTGA were more likely to have symptoms at 2 (34% vs 19%, P , .001) and 3 years of age (28% vs 19%, P = .009) but not at 4 years (27% vs 21%, NS). Z-scores for height, weight, and BMI did not differ between groups. In children with persistent tTGA, having $1 symptom was associated with family history of CD (odds ratio = 2.59, 95% confidence interval, 1.21-5.57) but not with age, gender, or HLA-DR3-DQ2 homozygosity. At seroconversion, tTGA levels were higher in symptomatic than asymptomatic children (P , .001), in those from CD families (P , .001), and in US participants (P , .001) but not associated with age, gender, or HLA genotype. tTGA levels correlated with severity of mucosal lesions both in symptomatic (r = 0.53, P , .001) and asymptomatic children (r = 0.22, P = .01).

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“…Maintenance of a GFD entails the avoidance of the ingestion of any products containing even small amounts of wheat, rye, and barley. Complete gluten withdrawal in patients diagnosed with classic symptoms has been shown to lead to normalization of standardized mortality rate [7,8], as well as improvement in the majority of related problems including osteoporosis and osteopenia [9], anemia [10], risk of malignancy [7,11], gastrointestinal symptoms [10], and in several studies, psychological well-being and quality of life [12][13][14][15].…”

Section: Introductionmentioning

confidence: 99%

Factors that Influence Adherence to a Gluten-Free Diet in Adults with Celiac Disease

et al. 2007

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Objective-The only treatment for celiac disease is lifelong adherence to a gluten-free diet, yet adherence is limited and factors influencing adherence are poorly understood. The purpose of this study was to determine factors influencing gluten-free diet adherence in adults with celiac disease.Methods-A questionnaire was developed and administered to 154 adults with celiac disease who then underwent a standardized gluten-free diet evaluation by an experienced nutritionist. Multivariate analysis was conducted to determine factors associated with adherence level.Results-Thirteen factors hypothesized to contribute to gluten-free diet adherence were found to be significantly associated with improved adherence including: understanding of the gluten-free diet, membership of a celiac disease advocacy group, and perceived ability to maintain adherence despite travel or changes in mood or stress (P < 0.001). Conclusions-This study identified specific factors correlated with gluten-free diet adherence. These results provide a foundation for the design of educational interventions to improve adherence. NIH Public Access

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Gluten-free diet may alleviate depressive and behavioural symptoms in adolescents with coeliac disease: a prospective follow-up case-series study

Cited by 86 publications

References 33 publications

Depression and anxiety in child and adolescents with follow-up celiac disease and in their families

Depression and anxiety in child and adolescents with follow-up celiac disease and in their families

Clinical Features of Celiac Disease: A Prospective Birth Cohort

Factors that Influence Adherence to a Gluten-Free Diet in Adults with Celiac Disease

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