Glycation, Glycoxidation and other Maillard Reaction Products

Monnier, Vincent M.; Fogarty, John; Monnier, Camille; Sell, David R.

doi:10.1201/b14256-37

Cited by 8 publications

(6 citation statements)

References 76 publications

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“…In contrast to pentosidine which can be only produced by glycoxidation, CML may also stem from lipid peroxidation with the presence of proteins. Both pentosidine and CML can be formed from a wide arrange of carbohydrates including glucose and ribose (Monnier, Fogarty, Monnier, & Sell, 1999). Effects of Chlorella and Nitzschia laevis on the formation of these two important specific AGEs were evaluated.…”

Section: Resultsmentioning

confidence: 99%

Inhibitory effects of microalgal extracts on the formation of advanced glycation endproducts (AGEs)

et al. 2010

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Section: Resultsmentioning

confidence: 99%

Inhibitory effects of microalgal extracts on the formation of advanced glycation endproducts (AGEs)

et al. 2010

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“…Pentosidine was determined by a dual technique involving C-18 reverse phase and ion exchange chromatography [8]. Carboxymethyl-lysine (CML) was determined using the HPLC twostep procedure originally described by Glomb [20] and further detailed in Monnier et al [21].…”

Section: Biochemical Assaysmentioning

confidence: 99%

Green Tea Extract Suppresses the Age-Related Increase in Collagen Crosslinking and Fluorescent Products in C57BL/6 Mice

Rutter

Sell

Fraser

et al. 2003

International Journal for Vitamin and Nutrition Research

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Collagen crosslinking during aging in part results from Maillard reaction endproducts of glucose and oxoaldehydes. Because of the tight link between oxidative and carbonyl stress, we hypothesized that natural antioxidants and "nutriceuticals" could block collagen aging in C57BL/6 mice. Six groups of young and adult mice received vitamin C, vitamin E, vitamin C&E, blueberry, green tea extract (GTE), or no treatment for a period of 14 weeks. Body weights and collagen glycation were unaltered by the treatment. However, GTE or vitamin C&E combined blocked tendon crosslinking at 10 months of age (p < 0.05, adult group). GTE also blocked fluorescent products at 385 and 440 nm (p = 0.052 and < 0.05, respectively) and tended to decrease skin pentosidine levels. These results suggest that green tea is able to delay collagen aging by an antioxidant mechanism that is in part duplicated by the combination of vitamin C and E.

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“…First, surveying physiological or other characteristics in a variety of species with a range of aging rates can help in identifying putative aging mechanisms (e.g., oxidative or glycoxidative processes; failure of DNA repair, etc.) (Ku and Sohal 1993;Shay 1995;Barja 1998;Monnier et al 1999). It should be noted, however, that such surveys can identify correlation, but not actual causative mechanisms.…”

Section: Comparative Methods and The Biology Of Agingmentioning

confidence: 99%

Comparative and alternative approaches and novel animal models for aging research

Holmes

Kristan

2008

AGE

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This special issue of AGE showcases powerful alternative or unconventional approaches to basic aging research, including the use of exceptionally long-lived animal model species and comparative methods from evolutionary biology. In this opening paper, we introduce several of these alternative aging research themes, including the comparative phylogenetic approach. This approach applies modern inferential methods for dissecting basic physiological and biochemical mechanisms correlated with phenotypic traits including longevity, slow aging, sustained somatic maintenance, and repair of molecular damage. Comparative methods can be used to assess the general relevance of specific aging mechanismsincluding oxidative processes-to diverse animal species, as well as to assess their potential clinical relevance to humans and other mammals. We also introduce several other novel, underexploited approaches with particular relevance to biogerontology, including the use of model animal species or strains that retain natural genetic heterogeneity, studies of effects of infectious disease and parasites on aging and responses to caloric restriction, studies of reproductive aging, and naturally occurring sex differences in aging. We emphasize the importance of drawing inferences from aging phenomena in laboratory studies that can be applied to clinically relevant aging syndromes in long-lived, outbred animals, including humans.

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Glycation, Glycoxidation and other Maillard Reaction Products

Cited by 8 publications

References 76 publications

Inhibitory effects of microalgal extracts on the formation of advanced glycation endproducts (AGEs)

Inhibitory effects of microalgal extracts on the formation of advanced glycation endproducts (AGEs)

Green Tea Extract Suppresses the Age-Related Increase in Collagen Crosslinking and Fluorescent Products in C57BL/6 Mice

Comparative and alternative approaches and novel animal models for aging research

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