Glycemia in Spontaneous Intracerebral Hemorrhage: Clinical Implications

Alvis-Miranda, Hernando Raphael; Alcalá-Cerra, Gabriel; Moscote-Salazar, Luís Rafael

doi:10.2478/romneu-2014-0043

Cited by 4 publications

(3 citation statements)

References 44 publications

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“…This condition plays a vital role in worsening lesions in the brain through increasing oxidative stress and cytokines, inducing excitotoxicity (stimulating NMDA receptors), increasing the influx of calcium into cells, and changing brain metabolism and perfusion. 36 We observed no significant association between the location and volume of haematoma and neurological deterioration nor expansion into the ventricles. This finding is in line with a study by Jones et al that reported no association between the location of supratentorial and infratentorial haematomas and 30-day mortality.…”

Section: Discussioncontrasting

confidence: 60%

Neutrophil-Lymphocyte ratio as a predictor of haemorrhagic stroke outcomes

Setiarini

Subagya

Setyopranoto

2022

JKKI

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Background: Haemorrhagic stroke causes high disability and mortality. Moreover, the prevalence is increasing. There is evidence of the involvement of the inflammatory process in haemorrhagic strokes. The neutrophil-lymphocyte ratio (NLR) is a strong and easily assessed marker of inflammation. Objective: This study aims to determine the NLR during hospital admission as a predictor of neurological deterioration in acute haemorrhagic strokes.Methods: This study was a prospective cohort study. The subjects were acute haemorrhagic stroke patients treated at the Stroke Unit of the RSUP Dr. Sardjito between March and November 2018. The demographic and laboratory test data, including NLR and National Institutes of Health Stroke Scale (NIHSS) measurement upon admission, were investigated. Logistic regression was performed to identify independent risk factors of neurological deterioration.Results: A total of 65 haemorrhagic stroke patients were included in this study. There were 21 subjects experiencing neurological deterioration, and 44 subjects did not. In bivariate analysis, there was a significant association between hyperglycaemia and neurological deterioration (RR=3.073; 95%CI=1.772-5.329; p=0.011). Glasgow Coma Scale (GCS) at admission was significantly associated with neurological deterioration (RR=2.732; 95%CI=1.455-5.131; p=0.006) as well as the NLR (RR=3.750; 95%CI=1.229-9.4441; p=0.005). The logistic regression results demonstrated that the variables that independently influenced neurological deterioration were NLR (RR= 4.424; 95%CI=1.196-16.369; p=0.026) and GCS (RR=7.461; 95%CI=1.711-32.526; p=0.007).Conclusion: High NLR can predict deterioration in acute haemorrhagic stroke.

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Section: Discussioncontrasting

confidence: 60%

Neutrophil-Lymphocyte ratio as a predictor of haemorrhagic stroke outcomes

Setiarini

Subagya

Setyopranoto

2022

JKKI

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“…In addition, in hemorrhagic stroke, there is direct infiltration of blood components such as red blood cells, leukocytes, macrophages, and plasma proteins in the area where bleeding occurs. So there is a high inflammatory response following the infiltration of blood components, the inflammatory response in the form of the release of inflammatory mediators, activation of proteases, microglia cells, and astrocyte cells in response to nerve tissue damage [45]. This more significant inflammatory reaction will trigger a greater stress response as well.…”

Section: Resultsmentioning

confidence: 99%

The Analysis of Ischemic Stroke and Hemorrhagic Stroke based on Sugar Level

Simarmata

Suryanegara²

2022

J. Drug Delivery Ther.

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Stroke is the second leading cause of death worldwide, and stroke is more severe in patients with hemorrhagic stroke than ischemic stroke. Nearly 2 out of 3 patients with acute stroke have a high blood glucose level as a physiological response to an acute disease. Poor clinical outputs are often found in acute stroke patients with hyperglycemia. This study aims to determine the differences in blood glucose levels in ischemic stroke and hemorrhagic stroke patients in UKI General Hospital. It is descriptive observational research with the cross-sectional method. The sample is 132 patients, using total sampling with specified inclusion and exclusion criteria. The data used is secondary data. Data processing was performed using SPSS. The study revealed that from 108 ischemic stroke patients, 79 patients (73,1%) showed an increase in blood glucose level, and out of 24 hemorrhagic stroke patients, all the patients showed an increase in blood glucose level. The mean value of blood glucose level during ischemic stroke is 129,83mg/dL and in hemorrhagic stroke is 151,12mg/dL. The conclusion of this study, there is a significant difference (= 0,001) in blood glucose level, and the mean value of blood glucose level in hemorrhagic stroke is higher than in ischemic stroke. Keywords: Random Blood Glucose, Ischemic stroke, hemorrhagic stroke, UKI General Hospital

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“…Glucose dysregulation is a common situation in neurocritical patients. Since 1849, the association between hyperglycemia and prognosis has been described in patients with cerebral infarction, a situation that has been repeated in more recent studies [55,56], which also include patients with acute brain injury secondary to other situations such as meningitis and cranioencephalic trauma [57].…”

Section: Glucose Brain Concentration In the Intensive Care Unitmentioning

confidence: 95%

Hypoglycemia and Brain: The Effect of Energy Loss on Neurons

Martínez-Piña¹,

Alvarado-Fernández²,

González-Guevara³

et al. 2022

Basics of Hypoglycemia

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Glucose provides the necessary fuel to cover the physiological functions of the organism. In the brain, glucose represents the main energy supply through the generation of adenosine triphosphate, with oxygen and glucose being the main components involved. The imbalance in glucose levels in the central nervous system produces substantial changes in metabolism. Hypoglycemia, or decreased blood glucose levels below 50 mg/dl, is accompanied by symptoms such as decreased performance of cognitive tasks such as verbal fluency, reaction time, arithmetic ability, verbal memory and visual, in addition to excitotoxicity, oxidative stress, neuroinflammation and apoptosis. Hyperglycemia participates in some cardiovascular diseases, neuropathy, nephropathy, retinopathy. Changes in glucose metabolism must be regulated and considered in order to obtain the best treatment for different pathologies, such as infections, non-infections, traumatic, primary or acquired.

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Glycemia in Spontaneous Intracerebral Hemorrhage: Clinical Implications

Cited by 4 publications

References 44 publications

Neutrophil-Lymphocyte ratio as a predictor of haemorrhagic stroke outcomes

Neutrophil-Lymphocyte ratio as a predictor of haemorrhagic stroke outcomes

The Analysis of Ischemic Stroke and Hemorrhagic Stroke based on Sugar Level

Hypoglycemia and Brain: The Effect of Energy Loss on Neurons

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