Glycemic and insulinemic meal responses modulate postprandial hepatic and intestinal lipoprotein accumulation in obese, insulin-resistant subjects

Harbis, Amandine; Perdreau, Sophie; Vincent-Baudry, Stéphanie; Charbonnier, Monique; Bernard, M.; Raccah, D.; Senft, M.; Lorec, Anne-Marie; Defoort, Catherine; Portugal, Henri; Vinoy, Sophie; Lang, Vincent; Lairon, Denis

doi:10.1093/ajcn/80.4.896

Cited by 99 publications

(69 citation statements)

References 53 publications

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“…Insulin resistant states have been extensively shown to be associated with increased hepatic and intestinal TRL secretion resulting in hypertriglyceridemia, concomitant increase in apoB and reduction in plasma levels of HDL cholesterol [2,10]. They are generally associated with high amplitude of postprandial lipemia [1,17]. Paradoxically here, parameters such as baseline fasting apoB 48, triglycerides and TRL triglycerides, which are usually linked to chylomicron remnant metabolism [22,44], were lower in T/T subjects than in C carriers.…”

Section: Discussionmentioning

confidence: 99%

APOB-516 T allele homozygous subjects are unresponsive to dietary changes in a three-month primary intervention study targeted to reduce fat intake

Hammoud¹,

Gastaldi²,

Maillot³

et al. 2009

Genes Nutr

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Dietary guidelines aim to control fat intake and reduce cardiovascular risk but an important interindividual variability occurs among subjects. The objective was to investigate whether the response of lipid and glucose homeostasis parameters after a three-month diet aimed at reducing cardiovascular risk could be modulated by the -516C/T polymorphism in the apolipoprotein B gene (APOB). Middle-aged men (n = 69) and women (n = 100) with moderate cardiovascular disease risk were advised to reduce total energy and fat intakes and replace saturated dietary fat by monounsaturated and polyunsaturated fat. Subjects were genotyped for APOB-516C/T polymorphism. At the entry and at the end of the three-month period, fasting and postprandial plasma lipid analyses were performed. At entry, subjects homozygous for the APOB-516 T allele exhibited significantly lower fasting plasma concentrations of apolipoprotein B 48, triglycerides and triglyceride-rich lipoproteins-triglycerides compared to C carrier subjects. After the diet period, while C carrier subjects presented a clear improvement of most biological parameters, paradoxically T/T subjects did not modify them. In addition, the apoB 48 postprandial response after a standardized mixed test meal was not improved in T/T subjects after the threemonth diet, contrary to C allele carriers. Even though their phenotype at entry does not show any significant increase of risk factors when compared to other groups, subjects homozygous for the APOB-516 T allele are unresponsive to a healthy diet that improves cardiovascular risk status in the whole population.

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Section: Discussionmentioning

confidence: 99%

APOB-516 T allele homozygous subjects are unresponsive to dietary changes in a three-month primary intervention study targeted to reduce fat intake

Hammoud¹,

Gastaldi²,

Maillot³

et al. 2009

Genes Nutr

Self Cite

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show abstract

“…Venous blood samples were collected prior to each test meal (time 0) and then at 1 hour, 3 hour, and 5 hour after completion of the meal. Subjects were given 20 minutes to consume the test meals similar to other studies measuring postprandial lipid response [17,[36][37][38]. Plasma or serum samples were frozen at -70°C until analyses.…”

Section: Study Design and Test Mealsmentioning

confidence: 99%

“…Harbis, et al, [17] found that a meal with rapidly digested carbohydrate compared to a meal with slowly digested carbohydrate increased postprandial triglyceride response. In contrast, Perälä, et al, [29] and Bukkapatnam, et al, [28] found a greater postprandial triglyceride response after a low GI meal compared to a high GI meal.…”

Section: Introductionmentioning

confidence: 99%

“…However, not all studies find disease associations [11][12][13]. In addition to alterations in blood glucose, GI and GL may influence the risk of cardiovascular disease by raising plasma triglyceride [14][15][16][17][18][19] and reducing HDLcholesterol [14,15,[18][19][20][21][22][23], particularly in obese individuals [16][17][18].…”

Section: Introductionmentioning

confidence: 99%

“…Most studies on the short-term impact of meal GI measured the glucose and/or insulin response, while only a few measured blood lipid response [17,[26][27][28][29]. Harbis, et al, [17] found that a meal with rapidly digested carbohydrate compared to a meal with slowly digested carbohydrate increased postprandial triglyceride response.…”

Section: Introductionmentioning

confidence: 99%

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No Apparent Impact of Meal Glycemic Index on Postprandial Lipid Response in Lean and Abdominally Obese Women

Silliman¹,

Mahoney²,

Michels³

et al. 2012

TONUTRJ

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Abstract:The objective of this study was to investigate effects of a low and high glycemic index (GI) meal and abdominal obesity on postprandial lipid response. Twenty-six obese and 15 lean women consumed a high (66) or low GI (44) meal of similar macronutrient and energy composition and then returned one to two weeks later to consume the other meal. Blood samples (0, 1, 3, 5 hour) were analyzed for insulin; free fatty acids; and total-, and chylomicron (CM)-triglycerides. Both groups (obese and lean, respectively) had significantly (p<0.05) greater insulin AUCs after consuming the high GI meal (1264 ± 889 vs. 653 ± 431 pmol/L) than the low GI meal (764 ± 708 vs. 320 ± 243). Meal type had no effect on the AUC for total-, or CM-triglyceride. Obese subjects had higher postprandial insulin (p<0.05), free fatty acid ((p<0.05), total-(p=0.06) and CM-triglycerides (p<0.05). QUICKI, an index of insulin sensitivity, was used to compare subjects from the upper and lower quartiles. Subjects with a QUICKI  0.31 (n=10) had higher AUCs for insulin (3-fold) and triglyceride (2.5-fold); and TG/HDL-C (3-fold) than subjects with a QUICKI ≥ 0.35 (n=9). These later subjects had a slightly reduced triglyceride AUC after the high GI meal (p=0.12). Women with abdominal obesity and insulin resistance have greater postprandial triglyceride response. The high GI meal increased the postprandial insulin response but appeared to have no effect on postprandial lipids. In this study, single meal GI had no effect on postprandial lipids but more research is needed, both short-and long-term studies.

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Slowly Digestible Starch and Health Benefits

Zhang

Hamaker

2013

Resistant Starch

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Glycemic and insulinemic meal responses modulate postprandial hepatic and intestinal lipoprotein accumulation in obese, insulin-resistant subjects

Abstract: Mixed meals containing slowly digestible carbohydrate that induces low glycemic and insulinemic responses reduce the postprandial accumulation of both hepatically and intestinally derived triacylglycerol-rich lipoproteins in obese subjects with insulin resistance.

Cited by 99 publications

References 53 publications

APOB-516 T allele homozygous subjects are unresponsive to dietary changes in a three-month primary intervention study targeted to reduce fat intake

APOB-516 T allele homozygous subjects are unresponsive to dietary changes in a three-month primary intervention study targeted to reduce fat intake

No Apparent Impact of Meal Glycemic Index on Postprandial Lipid Response in Lean and Abdominally Obese Women

Slowly Digestible Starch and Health Benefits

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