Glycemic Control and the Heart: The Tale of Diabetic Cardiomyopathy Continues

Longo, Miriam; Scappaticcio, Lorenzo; Cirillo, Paolo; Maio, Antonietta Di; Carotenuto, Raffaela; Maiorino, Maria Ida; Bellastella, Giuseppe; Esposito, Katherine

doi:10.3390/biom12020272

Cited by 18 publications

(12 citation statements)

References 121 publications

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“…Future research should focus on developing more efficient platforms for cardiomyocyte capture, improving sequencing coverage, and reducing costs in order to conduct large-scale single-cell sequencing experiments to address clinical problems related to the cardiovascular system. For example, breakthroughs have already been made in the fields of metabolic heart diseases, including diabetic cardiomyopathy ( 120 ) and Alcoholic-dilated Cardiomyopathy ( 121 ). In addition, scRNA-seq should be improved in terms of sequencing technology standardization, and visualization of analysis results in order to meet the needs of integrated multi-omics research.…”

Section: Discussionmentioning

confidence: 99%

Advances in application of single-cell RNA sequencing in cardiovascular research

Zhang

Liu

et al. 2022

Front. Cardiovasc. Med.

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Single-cell RNA sequencing (scRNA-seq) provides high-resolution information on transcriptomic changes at the single-cell level, which is of great significance for distinguishing cell subtypes, identifying stem cell differentiation processes, and identifying targets for disease treatment. In recent years, emerging single-cell RNA sequencing technologies have been used to make breakthroughs regarding decoding developmental trajectories, phenotypic transitions, and cellular interactions in the cardiovascular system, providing new insights into cardiovascular disease. This paper reviews the technical processes of single-cell RNA sequencing and the latest progress based on single-cell RNA sequencing in the field of cardiovascular system research, compares single-cell RNA sequencing with other single-cell technologies, and summarizes the extended applications and advantages and disadvantages of single-cell RNA sequencing. Finally, the prospects for applying single-cell RNA sequencing in the field of cardiovascular research are discussed.

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Section: Discussionmentioning

confidence: 99%

Advances in application of single-cell RNA sequencing in cardiovascular research

Zhang

Liu

et al. 2022

Front. Cardiovasc. Med.

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“…The significant reduction of FBGL by the combinations of ML/MS supplemented diets and ACA could prove their effective use in DCM management, most especially at the higher dose of ML diets plus ACA. The glucose reduction by the plant materials is a notable potential therapeutic scheme for DMC management (Longo et al, 2022). However, the improved antihyperglycemic effect observed could be a reflection of the synergistic power of the polyphenols present in Moringa (Table S2) and ACA as the highest inclusion of Moringa exhibited an improved ameliorative effect on FBGL.…”

Section: Discussionmentioning

confidence: 99%

Synergistic cardioprotective ability of co‐administration of Moringa supplemented diets and acarbose in diabetic cardiomyopathy involves attenuation of cholinergic, purinergic, monoaminergic, renin‐angiotensin system, and antioxidant pathways

Oyeleye

Ademiluyi

Ojo

et al. 2022

Journal of Food Biochemistry

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One of the major complications of diabetes mellitus (DM) is diabetic cardiomyopathy (DCM) due to the multifaceted therapy involved. Here, we evaluated the combinatorial effect of Moringa leaf (ML) and seed (MS) supplemented diets plus acarbose (ACA) on cardiac acetylcholinesterase (AChE), adenosine triphosphatase (ATPase), adenosine deaminase (ADA), monoamine oxidase (MAO), arginase, angiotensin‐I converting enzyme (ACE), and lactate dehydrogenase (LDH) activities, thiobarbituric acid reactive species (TBARS), and thiols levels. The diets and ACA (25 mg/kg) were administered for 14 days. The fasting blood glucose level (FBGL), cardiac AChE, ATPase, ADA, MAO, arginase, ACE, LDH activities, and TBARS and thiol levels were determined. Relative to the normal rats, the biomarkers were significantly increased in DM rats but were suppressed significantly in the diets plus ACA‐treated rats while improving antioxidant status, with the 4% Moringa plus ACA proving outstanding compared to individual ML/MS and ACA. In addition, ML‐supplemented diets with/without ACA had better effects compared to MS with/without ACA, respectively. In conclusion, the combination of ML/MS supplemented diets and ACA synergistically modulates the tested biochemicals. However, the effect on blood vessels and the nerves that control the heart, stiffness of left ventricular (LV) hypertrophy, fibrosis, cell signaling abnormalities, related gene expression, clinical trials, and echocardiology studies should be further investigated to affirm this claim. Practical applications Moringa oleifera has been a vocal appetite in mitigating cardiovascular disease induced by diabetes, but the formulation of a medicinal diet as an ameliorative route of attention to the pathology is fairly addressed, not talking of its combination with the synthetic antidiabetic drug, such as ACA. Based on this experiment, it is imperative to explore such an idea. This research shows that co‐administration of moringa leaf/seed formulated diets plus ACA exhibits a synergistic effect in DCM management. However, further research is needed in this field of experiment.

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“…DM causes several alterations in cardiac energy handling and myocardial performance [ 12 ]. In the presence of any disturbance of glucose metabolism, cardiac adenosine triphosphate (ATP) production is affected.…”

Section: Major Interconnections Between Dm and Hfmentioning

confidence: 99%

“…Obesity affects myocardial structure and performance through systemic inflammation, epicardial adipose tissue (EAT) accumulation and consequently the development of the clinical condition described as “Cardiac steatosis”. Furthermore, myocardial fibrosis, augmented production of reactive oxygen species (ROS) and reduced production of nitric oxide (NO) by endothelium and increased myocyte stiffness are several mechanisms behind cardiac dysfunction in diabetes [ 12 ]. In obese type 2 diabetes mellitus (T2DM) patients, the unfavorable metabolic environment characterized by hyperglycemia, lipotoxicity, abundance of AGEs and hyperinsulinemia can induce coronary microvascular dysfunction, and lead to the development of heart failure with preserved ejection fraction (HFpEF) [ 8 ].…”

Section: Major Interconnections Between Dm and Hfmentioning

confidence: 99%

Cardiometabolic Care: Assessing Patients with Diabetes Mellitus with No Overt Cardiovascular Disease in the Light of Heart Failure Development Risk

et al. 2023

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The mechanisms leading to the development of heart failure (HF) in diabetes mellitus (DM) patients are multifactorial. Assessing the risk of HF development in patients with DM is valuable not only for the identification of a high-risk subgroup, but also equally important for defining low-risk subpopulations. Nowadays, DM and HF have been recognized as sharing similar metabolic pathways. Moreover, the clinical manifestation of HF can be independent of LVEF classification. Consequently, approaching HF should be through structural, hemodynamic and functional evaluation. Thus, both imaging parameters and biomarkers are important tools for the recognition of diabetic patients at risk of HF manifestation and HF phenotypes, and arrhythmogenic risk, and eventually for prognosis, aiming to improve patients’ outcomes utilizing drugs and non-pharmaceutical cardioprotective tools such as diet modification.

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Glycemic Control and the Heart: The Tale of Diabetic Cardiomyopathy Continues

Cited by 18 publications

References 121 publications

Advances in application of single-cell RNA sequencing in cardiovascular research

Advances in application of single-cell RNA sequencing in cardiovascular research

Synergistic cardioprotective ability of co‐administration of Moringa supplemented diets and acarbose in diabetic cardiomyopathy involves attenuation of cholinergic, purinergic, monoaminergic, renin‐angiotensin system, and antioxidant pathways

Cardiometabolic Care: Assessing Patients with Diabetes Mellitus with No Overt Cardiovascular Disease in the Light of Heart Failure Development Risk

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