Glyceollin, a soybean phytoalexin with medicinal properties

Ng, Tzi Bun; Ye, Xiu Juan; Wong, Jack Ho; Fang, Evandro Fei; Chan, Yau Sang; Pan, Wenliang; Ye, Xiu Yun; Sze, Stephen Cho Wing; Zhang, Kalin Yanbo; Liu, Fang; Wang, He Xiang

doi:10.1007/s00253-011-3169-7

Cited by 48 publications

(27 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This chemically heterogeneous group of compounds is also produced by a wide range of crop plants including Brassicaceae, Solanaceae, Vitaceae, Fabaceae, and Poaceae and is generally regarded as molecular markers for disease resistance (Ahuja et al 2012). Since the introduction of the concept of phytoalexins in 1940, they have been extensively studied, not only with respect to their roles in defence against pests and pathogens but also with respect to their health-promoting effects (Boue et al 2009;Holland and O'Keefe 2010;NG et al 2011;Pedras et al 2011a;Smoliga et al 2011). …”

Section: The Biosynthesis and Role Of Sulphur-based Phytoalexinsmentioning

confidence: 98%

Applied Cell Biology of Sulphur and Selenium in Plants

Khan¹,

Hell

2013

Plant Cell Monographs

View full text Add to dashboard Cite

Sulphur (S) is required in considerable amounts by all organisms, while selenium (Se) is beneficial for plants and essential for animals albeit in only small amounts. Due to their chemical similarity that is in parts also shared with molybdenum and chromium, inorganic sulphate and selenate are taken up by plants and assimilated in reduced form into organic compounds, most notably cysteine and selenocysteine, respectively. Uptake, reduction, and storage of S and Se compounds underlie complex cellular processes that need to be understood before successful translation into improved plants for human and animal diets can be achieved. Genetic engineering, breeding, and plant production approaches use insights from cell biology and basic research to introduce tailor-made desirable traits related to S and Se metabolism. Several examples for this approach will be discussed. In terms of enhanced crop quality, the so-called push and pull approaches to improve seed S amino acid compositions draw heavily from cell biology research. In pull or sink approaches, the expression of S-rich seed storage proteins is put under the control of seed-specific promoters. Such proteins possibly carry a targeting signal for the endoplasmic reticulum to achieve deposition in protein bodies. The regulation of some health-promoting compounds of Se together with S compounds such as glucoraphanin in Brassicaceae has received considerable attention in the recent past. However, to achieve high contents of Se metabolites simultaneously with the health-promoting S-containing compounds is challenging due to the crosstalk between the two pathways. The concept of S-enhanced defence linking S nutrition of plants with enhanced synthesis of S-containing defence compounds has been supported by considerable experimental data from basic research. Some of the

show abstract

Section: The Biosynthesis and Role Of Sulphur-based Phytoalexinsmentioning

confidence: 98%

Applied Cell Biology of Sulphur and Selenium in Plants

Khan¹,

Hell

2013

Plant Cell Monographs

View full text Add to dashboard Cite

show abstract

“…Glyceollins, a family of prenylated pterocarpans derived from daidzein, are specifically induced in soybeans response to pathogens such as Phytophthora sojae and Macrophomina phaseolina (Ng et al 2011). The crucial step in glyceollin biosynthesis is the prenylation of glycinol, a reaction catalyzed by the prenyltransferases G2DT and G4DT (Akashi et al 2009).…”

Section: Interactions With Pathogensmentioning

confidence: 99%

Flavonoids in plant rhizospheres: secretion, fate and their effects on biological communication

Sugiyama

Yazaki

2014

Plant Biotechnology

View full text Add to dashboard Cite

Flavonoids, one of the most-described group of plant "specialized metabolites", consist of more than 10,000 structurally diverse compounds. Most flavonoids accumulate in plant vacuoles as glycosides, with some released by the roots into rhizospheres. These flavonoids are involved in biological communications with rhizobia, arbuscular mycorrhizal fungi, plant growth promoting rhizobacteria, pathogens, nematodes, and other plant species. Both aglycones and glycosides of flavonoids are found in root exudates and in soils. This review describes researches on the mechanisms of flavonoid secretion and the fate of flavonoids released into rhizospheres. This review also discusses the direction of future research that may elucidate the specific roles of flavonoids in biological communications in rhizospheres, enabling the utilization of flavonoid activities and functions in agricultural practice.

show abstract

“…Glyceollin is the main phytoalexin in soybean, with beneficial health effects 20,21 . It acts as an antioxidant 22 , antifungal 23 , anticancer 24 , and anti-inflammation 25,26 substance and might improve insulin sensitivity 27,28 .…”

Section: Introductionmentioning

confidence: 99%

Elicited soybean (Glycine max L.) extract improves regulatory T cell activity in high fat-fructose diet mice

Atho'illah

Widyarti

Rifa’i

2017

AIP Conference Proceedings

View full text Add to dashboard Cite

Obesity is a metabolic disorder characterized by the central distribution of abdominal fat, hyperglycemia, hyperlipidemia, and hypertension. A high-fat diet can lead to overnutrition and directly trigger inflammation in adipose tissue. Regulatory T cells (Tregs) are essential negative regulators of inflammation. Soybean (Glycine max L.) has a variety of beneficial health. It contains isoflavones, particularly daidzein and genistein which can be transformed using microbial and physical stimuli to enhance bioactivity. The aim of this study was to analyze the effect of elicited soybean extract (ESE) on Treg activity in high fat-fructose (HFFD) mice. Twenty-eight female Balb/C mice were divided into seven groups: normal diet (ND) only, ND + ESE 104 mg/kg BW, HFFD only, HFFD + Simvastatin 2.8 mg/kg, HFFD + ESE 78 mg/kg BW, HFFD + ESE 104 mg/kg BW, and HFFD + ESE 130 mg/kg BW. The high fat-fructose diet was given over a period of 20 weeks, and ESE was administered orally per day after 20 weeks for four weeks. At week 24, the animals were sacrificed and the spleen was collected. Tregs were labeled as CD4 + CD25 + CD62L + and the relative Treg number was measured using flow cytometry. The HFFD treatment significantly decreased Treg number (p < 0.05) compared to a normal diet. The ESE treatment in HFFD mice could improve Treg numbers compared to HFFD mice. Our results suggest that ESE has potential to be used as a supplement to suppress chronic inflammation via increased Treg number.

show abstract

Glyceollin, a soybean phytoalexin with medicinal properties

Cited by 48 publications

References 31 publications

Applied Cell Biology of Sulphur and Selenium in Plants

Applied Cell Biology of Sulphur and Selenium in Plants

Flavonoids in plant rhizospheres: secretion, fate and their effects on biological communication

Elicited soybean (Glycine max L.) extract improves regulatory T cell activity in high fat-fructose diet mice

Contact Info

Product

Resources

About