Glycerogelatin-based ocular inserts of aceclofenac: Physicochemical, drug release studies and efficacy against prostaglandin E2-induced ocular inflammation

Mathurm, Manish; Gilhotra, Ritu Mehra

doi:10.3109/10717544.2010.509366

Cited by 26 publications

(7 citation statements)

References 25 publications

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“…Animals were maintained in an institutional animal household and given unrestricted access to food and water. 32 For each group of rabbits, the right eyes were treated with 100 µL of AT-PLGA-CS-NPs (F1 in case of Group I), AT-PLGA-CS-NPs in thermosensitive gel (F2 for Group II), free AT in thermosensitive gel (F3 for Group III), and AT suspended in double-distilled water (F4 for Group IV). Left rabbit eyes served as control and were instilled with equal volumes of PBS (pH 7.4).…”

Section: Anti-inflammatory Studymentioning

confidence: 99%

Chitosan-Coated PLGA Nanoparticles for Enhanced Ocular Anti-Inflammatory Efficacy of Atorvastatin Calcium

Arafa¹,

Girgis²,

El-Dahan³

2020

IJN

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Background: Atorvastatin calcium (AT) is an ocular anti-inflammatory with limited bioavailability when taken orally due to its low solubility in low pH and extensive first-pass effect. To overcome these problems, AT was entrapped in polymeric nanoparticles (NPs) to improve surface properties and sustained release, in addition to achieving site-specific action. Methods: AT was entrapped in chitosan (CS)-coated polylactic-co-glycolic acid (PLGA) NPs to form AT-PLGA-CS-NPs (F1). F1 and free AT were embedded in thermosensitive Pluronic ® 127-hydroxypropyl methylcellulose (HPMC) to form thermosensitive gels (F2) and (F3) while F4 is AT suspension in water. F1 was assessed for size, surface charge, polydispersity index (PDI), and morphology. F2 and F3 were examined for gelation temperature, gel strength, pH, and viscosity. In vitro release of the four formulations was also investigated. The ocular irritancy and anti-inflammatory efficacy of formulations against prostaglandin E 1-(PGE 1) induced ocular inflammation in rabbits were investigated by counting the polymorphonuclear leukocytes (PMNs) and protein migrated in tears. Results: Oval F1 of 80.0-190.0±21.6 nm exhibited a PDI of 0.331 and zeta potential of 17.4 ±5.62 mV with a positive surface charge. F2 and F3 gelation temperatures were 35.17±0.22°C and 36.93±0.31°C, viscosity 12,243±0.64 and 9759±0.22 cP, gel strength 15.56±0.6 and 12.45 ±0.1 s, and pHs of 7.4±0.02 and 7.4±0.1, respectively. In vitro release of F1, F2, F3, and F4 were 48.21±0.31, 26.48±0.5, 84.76±0.11, and 100% after 24 hrs, respectively. All formulations were non-irritant. F2 significantly inhibited lid closure up to 3 h, PMN counts and proteins in tear fluids up to 5 h compared to other formulations. Conclusion: AT-PLGA-CS-NP thermosensitive gels proved to be successful ocular antiinflammatory drug delivery systems.

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Section: Anti-inflammatory Studymentioning

confidence: 99%

Chitosan-Coated PLGA Nanoparticles for Enhanced Ocular Anti-Inflammatory Efficacy of Atorvastatin Calcium

Arafa¹,

Girgis²,

El-Dahan³

2020

IJN

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“…Hence, it is suggested that a suitable buccal patch should have a relatively moderate TS and E/B. [ 15 ] For buccal application, soft and tough inserts are preferred as these can withstand the continuous mechanical stress due to movement of jaws or in the buccal cavity. The TS of the patches varied between 0.163 ± 0.08 and 0.469 ± 0.02 kg/mm 2 and E/B was between 16.96 ± 2.73 and 38.96 ± 1.31% [ Table 2 ].…”

Section: Resultsmentioning

confidence: 99%

“…The surface pH was measured by means of a pH paper placed on the surface of the swollen patch. [ 15 ]…”

Section: Methodsmentioning

confidence: 99%

Formulation and optimization of mucoadhesive buccal patches of losartan potassium by using response surface methodology

Ikram

Gilhotra

2015

Adv Biomed Res

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“…After 5 minutes, the ocusert was removed and the excess simulated tear fluid on the ocuserts was wiped and the ocusert was weighed again. [36] The % swelling index was calculated by the following formula, %Swelling index = (Weight of swollen ocusert after time t -original weight of ocusert) / original weight of ocusert x 100…”

Section: Swelling Indexmentioning

confidence: 99%

Formulation and evaluation of controlled release ocusert of gatifloxacin and prednisolone

Nagpal

Singh

Kaur

et al. 2021

Acta Marisiensis - Seria Medica

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Objective: Ocuserts are sterile, solid, or semisolid dosage forms prepared to attain increased contact time between the drug and the conjunctival tissue to keep up a constant release of drug when placed in the lower cul-de-sac or conjunctival sac of the eye. The aim of formulating this delivery system was to treat both inflammatory and infectious conditions of the eye with increased ocular residence time by releasing drugs at a slow and constant rate. Method: Gatifloxacin, and prednisolone ocuserts were prepared by solvent casting method, and evaluated for physical appearance, uniformity of weight, thickness, folding endurance, drug content, surface pH, in-vitro, and ex-vivo release profile. Results: All formulated inserts exhibited positive results in terms of their evaluation parameters. Ocuserts were sterile, with no turbidity in selected media during the study, and they were stable throughout six months. Conclusion: Results suggested that prepared optimized ocusert formulation would be a suitable alternative to eye drops for treating conjunctivitis and other bacterial infections.

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Glycerogelatin-based ocular inserts of aceclofenac: Physicochemical, drug release studies and efficacy against prostaglandin E₂-induced ocular inflammation

Cited by 26 publications

References 25 publications

<p>Chitosan-Coated PLGA Nanoparticles for Enhanced Ocular Anti-Inflammatory Efficacy of Atorvastatin Calcium</p>

<p>Chitosan-Coated PLGA Nanoparticles for Enhanced Ocular Anti-Inflammatory Efficacy of Atorvastatin Calcium</p>

Formulation and optimization of mucoadhesive buccal patches of losartan potassium by using response surface methodology

Formulation and evaluation of controlled release ocusert of gatifloxacin and prednisolone

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