Glyceryl trinitrate vs. ritodrine for the treatment of preterm labor

Wani, M.P; Barakzai, N; Graham, Iain H.

doi:10.1016/j.ijgo.2003.09.001

Cited by 12 publications

(15 citation statements)

References 2 publications

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“…Wani et al 5 found NTG to delay delivery beyond 7 days and 14 days in 87 % & 85 % of patients respectively compared to 73% & 69% in ritodrine group, where as Lees et al 4 found the same to be 77% & 73% for NTG versus 81% & 78% for ritodrine. The RNOTT trial 7 found pregnancy prolongation of more than 7 days in 53% in the NTG group as against 59% in ritodrine group.…”

Section: Discussionmentioning

confidence: 95%

“…Bisits et al 7 found similar results. Wani et al 5 observed the incidence of headache to be 25 % and total incidence of side effects with NTG to be 30%. Papatsonis et al 8 found the incidence of side effects with nifedipine to be significantly less when compared to ritodrine (18.9% versus 36%).…”

Section: Lees Et Almentioning

confidence: 99%

“…Efforts are therefore being directed towards finding alternatives that are safer, better tolerated as well as efficacious in prolonging pregnancy, thus allowing us time for maternal administration of corticosteroids & inutero transfer of the babies to units where facilities for neonatal intensive care is available. Both nitroglycerin [4][5][6][7] and nifedipine [8][9][10][11] have been shown to be effective in preterm labour. However, only one study 12 has directly compared these two tocolytic agents.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Nifedipine versus nitroglycerin for acute tocolysis in preterm labour: a randomised controlled trial

Dhawle

Kalra

Bagga

et al. 2013

Int J Reprod Contracept Obstet Gynecol

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Section: Discussionmentioning

confidence: 95%

Section: Lees Et Almentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Nifedipine versus nitroglycerin for acute tocolysis in preterm labour: a randomised controlled trial

Dhawle

Kalra

Bagga

et al. 2013

Int J Reprod Contracept Obstet Gynecol

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“…In addition to the above-mentioned studies, some other surveys have been published that compared GTN to ritodrine (14,20,21), magnesium sulfate (MgSO 4 ) (22), fenoterol magnesium sulfate (23), or salbutamol magnesium sulfate (24), as well as one case series (25).…”

Section: Discussionmentioning

confidence: 99%

Transdermal Nitroglycerin Versus Oral Nifedipine for Suppression of Preterm Labor

et al. 2015

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Background: One of the most serious complications of pregnancy is preterm labor (PTL) and delivery. Further, there are different tocolytic agents available to enhance the time of delivery. Objectives: The aim of this study was to compare the effectiveness of transdermal nitroglycerin (glyceryl trinitrate, GTN) and oral nifedipine for managing preterm labor. Patients and Methods:This was a randomized clinical trial involving women who were admitted to our hospital with a diagnosis of PTL. Group one received transdermal GTN, whereas group two received oral nifedipine. All vital signs, fetal heart rate (FHR), contractions, dilation, and effacement, as well as gestation age at the time of delivery, have been monitored and evaluated in both groups of patients. Our main goal was the postponement of delivery so as to secure the most beneficial effect of primary corticosteroid administration for the fetus. Results: Both groups were matched regarding age, gestational age at the time of tocolytic therapy, height of fundus, history of pregnancy, abortion, delivery, and stillbirth, primary body temperature, and systolic and diastolic blood pressure. Those who received GTN had a more prolonged delay of delivery. Also, the GTN group had infants with better one-and five-minute Apgar scores. Although both groups reported minimal side effects, tachycardia and nausea were reported more frequently in GTN patients. Conclusions: Transdermal GTN was shown to be more effective in controlling PTL compared to oral nifedipine in terms of both maternal and neonatal effects.

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“…The review of nitric oxide donors (glyceryl trinitrate; GTN) for the inhibition of threatened preterm labour included six trials (n = 704); one RCT 634 was added to the five primary studies 621,[635][636][637][638] identified in an earlier review. 639 Further details of the review can be found in …”

Section: Nitric Oxide Donors Tocolysismentioning

confidence: 99%

Screening to prevent spontaneous preterm birth: systematic reviews of accuracy and effectiveness literature with economic modelling

Honest

Ca²,

Durée³

et al. 2009

Health Technol Assess

189

146

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For primary prevention, an effective, affordable and safe intervention applied to all mothers without preceding testing is likely to be the most cost-effective approach in asymptomatic women in early pregnancy. For secondary prevention among women at risk of preterm labour in later pregnancy, a management strategy based on the results of testing is likely to be more cost-effective. Implementation of a treat-all strategy with simple interventions, such as fish oils, would be premature for asymptomatic women. Universal provision of high-quality ultrasound machines in labour wards is more strongly indicated for predicting spontaneous preterm birth among symptomatic women than direct management, although staffing issues and the feasibility and acceptability to mothers and health providers of such strategies need to be explored. Further research should include investigations of low-cost and effective tests and treatments to reduce and delay spontaneous preterm birth and reduce the risk of perinatal mortality arising from preterm birth.

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Glyceryl trinitrate vs. ritodrine for the treatment of preterm labor

Cited by 12 publications

References 2 publications

Nifedipine versus nitroglycerin for acute tocolysis in preterm labour: a randomised controlled trial

Nifedipine versus nitroglycerin for acute tocolysis in preterm labour: a randomised controlled trial

Transdermal Nitroglycerin Versus Oral Nifedipine for Suppression of Preterm Labor

Screening to prevent spontaneous preterm birth: systematic reviews of accuracy and effectiveness literature with economic modelling

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