Nifedipine versus nitroglycerin for acute tocolysis in preterm labour: a randomised controlled trial

Dhawle, Ajay; Kalra, Jaswinder; Bagga, Rashmi; Aggarwal, Neelam

doi:10.5455/2320-1770.ijrcog20130211

Cited by 9 publications

(23 citation statements)

References 15 publications

(30 reference statements)

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“…1,2 The overall incidence is 6-15% 3,4 accounting for nearly 75% of perinatal deaths in developing countries. 5 There is growing recognition of increased risk of infant mortality in moderate preterm birth between 32 to 37 weeks. 6,7 Preterm delivery remains a major public health problem in terms of loss of life, long term disability like cerebral palsy, blindness, deafness, chronic lung disease and developmental delay.…”

Section: Introductionmentioning

confidence: 99%

Glyceryl trinitrate patch versus intravenous ritodrine for tocolysis in pre-term labour

Jain

Sinha

Rani

et al. 2016

Int J Reprod Contracept Obstet Gynecol

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Section: Introductionmentioning

confidence: 99%

Glyceryl trinitrate patch versus intravenous ritodrine for tocolysis in pre-term labour

Jain

Sinha

Rani

et al. 2016

Int J Reprod Contracept Obstet Gynecol

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“…In another randomized controlled trial Dhawle A et al compared the safety and efficacy of oral nifedipine with transdermal nitroglycerin (NTG) in the inhibition of preterm labour. 19 The neonatal outcomes in terms of the mean birth weight, incidence of low birth weight and very low birth weight babies, need and duration of neonatal intensive care was similar in both groups. Their results were similar to ours that oral nifedipine is a safe and effective tocolytic with a lower failure rate and better side effect profile as compared with transdermal nitroglycerin.…”

Section: Discussionmentioning

confidence: 78%

Comparative study of nitroglycerin dermal patch versus nifedipine in the management of preterm labour

Kaur

Goel

Singh

2018

Int J Reprod Contracept Obstet Gynecol

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Background: The aim of present study was to compare the effect of nitroglycerin dermal patch and nifedipine for taking control of preterm labor (tocolysis) and to find the safer drug for mother and foetus.Methods: Women with signs and symptoms of preterm labor between gestational ages 26-37 weeks were studied. These women were divided into 2 groups. Group A-50 women were prescribed nitroglycerin dermal patch and in Group B-50 women were given nifedipine. Primary outcome of the study was to delay the delivery for at least 48 hours. Secondary outcomes were gestational age at the time of delivery, prolongation of labor, effect on neonate and adverse effects.Results: Both groups were comparable regarding cervical effacement in cm and gestational age in weeks at the time of enrollment. Gestational age at the time of delivery in weeks (p < 0.01), prolongation of pregnancy in days (p > 0.05), neonatal Apgar score at 5 minutes (p < 0.05), neonatal weight in kg (p < 0.05) and foetal outcomes were better in nifedipine group in comparison to nitroglycerin. The overall side effects were less in nifedipine group as compared to nitroglycerin group. Overall success rate was 88% with nifedipine and 76% in nitroglycerin cases.Conclusions: Both the drugs were able to postpone the delivery for 48 hours. Nifedipine was found to be superior to nitroglycerin dermal patch in prolongation of gestational age at the time of delivery, in perinatal outcome and maternal acceptance.

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“…The neonatal outcomes in terms of the mean birth weight, need and duration of neonatal intensive care was similar in both groups as observed in present study too. 10 Kashanian et al, did a randomised clinical trial comparing NTG and nifedipine as a tocolytic agent. They found that more number of women in NTG group delivered after 48 hours (52 women (86.7%) vs 41(68.3%), P=0.016) and after 7 days (47 (78.3%) vs 37 (61.7%), P=0.046), than women in the nifedipine group.…”

Section: Discussionmentioning

confidence: 99%

“…9 There are very few studies directly comparing the efficacy and safety of nifedipine and nitroglycerine as a tocolytic agent. [9][10][11] Thus, the present study was planned to compare nitroglycerine with nifedipine as tocolytics for preterm labour.…”

Section: Introductionmentioning

confidence: 99%

Oral nifedipine versus nitroglycerine patch for tocolysis in preterm labour

Sharma¹,

Rani

Huria

et al. 2018

Int J Reprod Contracept Obstet Gynecol

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Background: Preterm delivery is a major cause of neonatal mortality and morbidity. Various modalities have been used to prediction of patient at risk of preterm labor. But due to multi-factorial etiology these predictors are not always useful. Tocolysis has a major role in arresting preterm labor. The purpose of this study was to compare the safety and efficacy of oral nifedipine with transdermal nitroglycerine in the inhibition of preterm labour.Methods: This single blinded randomized control trial was conducted in the labour room of department of Obstetrics and Gynecology from January 2011 to June 2012. One hundred women with singleton pregnancy between 28 weeks to 34 weeks preterm labour and no contraindication for tocolysis were enrolled in the study. After taking the informed consent subjects were randomized into two groups. Randomization was done by random number table. Fifty-one subjects in nifedipine group received oral nifedipine (Tab Depin 10mg). Forty-nine subjects receiving transdermal nitroglycerine patch (Nitroderm Patch 10) were included in NTG group. The variables analysed were delay in delivery for 48 hours, 7 days or more than 7 days, period of gestation at delivery and side effect profile of drugs.Results: The percentage of women delivering after 48hours of administration of nifedipine group (52.9%) and nitroglycerine group (53.1%). Failure of tocolysis, defined as delivery within 48 hours, with nitroglycerine group (32.7 %) was comparable to nifedipine (33.3 %). Headache was significantly higher in nitroglycerine group as compared to nifedipine group (p≤0.001). Maternal tachycardia was more common in nifedipine group compared to NTG group (p=0.001).Conclusions: Oral nifedipine and transdermal nitroglycerine have similar efficacy as tocolytic agent in patients with preterm labour.

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Nifedipine versus nitroglycerin for acute tocolysis in preterm labour: a randomised controlled trial

Cited by 9 publications

References 15 publications

Glyceryl trinitrate patch versus intravenous ritodrine for tocolysis in pre-term labour

Glyceryl trinitrate patch versus intravenous ritodrine for tocolysis in pre-term labour

Comparative study of nitroglycerin dermal patch versus nifedipine in the management of preterm labour

Oral nifedipine versus nitroglycerine patch for tocolysis in preterm labour

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