Glyco-silicon Functional Materials as Anti-influenza Virus Agents

Abstract

This review shows introduction of glycoclusters using carbosilanes as core scaffolds, preparations of glycoclusters and their excellent properties as well as functions. Since a dendrimer has unique advantages such as single molecular weight, regularity of structure and easy control of shape and size, dendrimers are utilized in various research areas. Results of syntheses and biological evaluations of the carbosilane dendrimers having carbohydrate moieties for influenza viruses are presented.

Selective and Tunable Galectin Binding of Glycopolymers Synthesized by a Generalizable Conjugation Method

“…Glycopolymers are an important class of synthetic carbohydrate-containing macromolecules that feature pendant sugars. − The presentation of multiple sugar moieties along a polymer backbone results in increased binding to the complementary carbohydrate-binding proteins (lectins) compared to the individual sugars, due to the multivalent carbohydrate–protein interactions, termed as “cluster glycoside effect”. − They mimic the polyvalent display of oligosaccharides presented by a cell surface and can therefore serve as a valuable tool for probing carbohydrate–protein interactions in a number of important biological processes involving cell growth, cell differentiation, immune defense, pathogen invasion, inflammation, and cancer metastasis. , In this capacity, glycopolymers have found a variety of biomedical and pharmaceutical applications such as matrices for cell culture and scaffolds for tissue repair, , anti-infective and anticancer therapeutics, − and in vaccine design …”