Glycogen distribution in mouse hippocampus

Hirase, Hajime; Akther, Sonam; Wang, Xiaowen; Oe, Yuki

doi:10.1002/jnr.24386

Cited by 22 publications

(18 citation statements)

References 98 publications

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“…Glycogen in astrocytes is an emerging factor in memory consolidation. While astrocytes are the cell type that stores appreciable amounts of glycogen, their glycogen storage is heterogeneous in that there are glycogen-rich astrocytes and glycogen-poor astrocytes distinguished by the presence of glycogen largeparticles 50,51 In the current study, we showed the composition of adrenoreceptor subtypes is likely heterogeneous in individual astrocytes. Since astrocytic cAMP promotes glycogen metabolism, this may underlie the heterogeneous glycogen distribution.…”

Section: Discussionmentioning

confidence: 53%

Distinct temporal integration of noradrenaline signaling by astrocytic second messengers during vigilance

et al. 2020

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Astrocytes may function as mediators of the impact of noradrenaline on neuronal function. Activation of glial α1-adrenergic receptors triggers rapid astrocytic Ca 2+ elevation and facilitates synaptic plasticity, while activation of β-adrenergic receptors elevates cAMP levels and modulates memory consolidation. However, the dynamics of these processes in behaving mice remain unexplored, as do the interactions between the distinct second messenger pathways. Here we simultaneously monitored astrocytic Ca 2+ and cAMP and demonstrate that astrocytic second messengers are regulated in a temporally distinct manner. In behaving mice, we found that while an abrupt facial air puff triggered transient increases in noradrenaline release and large cytosolic astrocytic Ca 2+ elevations, cAMP changes were not detectable. By contrast, repeated aversive stimuli that lead to prolonged periods of vigilance were accompanied by robust noradrenergic axonal activity and gradual sustained cAMP increases. Our findings suggest distinct astrocytic signaling pathways can integrate noradrenergic activity during vigilance states to mediate distinct functions supporting memory.

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Section: Discussionmentioning

confidence: 53%

Distinct temporal integration of noradrenaline signaling by astrocytic second messengers during vigilance

et al. 2020

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“…Glycogen storage in the adult brain is highly compartmentalized, with the highest levels in the hippocampus, striatum, and superficial layers of the cortex (Oe et al, 2016). Immunohistochemical studies showed that glycogen has a punctate distribution localized predominantly in astrocytic processes (Oe et al, 2016;Hirase et al, 2019). These studies further indicated an astrocytic heterogeneity, whereas some astrocytes were ''glycogen-rich'' while others found to be glycogen-poor.…”

Section: Energy Metabolism During Neurodegenerationmentioning

confidence: 96%

Neuromodulation of Glial Function During Neurodegeneration

Stevenson

Samokhina

Rossetti

et al. 2020

Front. Cell. Neurosci.

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Glia, a non-excitable cell type once considered merely as the connective tissue between neurons, is nowadays acknowledged for its essential contribution to multiple physiological processes including learning, memory formation, excitability, synaptic plasticity, ion homeostasis, and energy metabolism. Moreover, as glia are key players in the brain immune system and provide structural and nutritional support for neurons, they are intimately involved in multiple neurological disorders. Recent advances have demonstrated that glial cells, specifically microglia and astroglia, are involved in several neurodegenerative diseases including Amyotrophic lateral sclerosis (ALS), Epilepsy, Parkinson's disease (PD), Alzheimer's disease (AD), and frontotemporal dementia (FTD). While there is compelling evidence for glial modulation of synaptic formation and regulation that affect neuronal signal processing and activity, in this manuscript we will review recent findings on neuronal activity that affect glial function, specifically during neurodegenerative disorders. We will discuss the nature of each glial malfunction, its specificity to each disorder, overall contribution to the disease progression and assess its potential as a future therapeutic target.

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“…For decades astrocytes have been considered fundamental for brain functions because of their metabolic support to neurons and for their ability to regulate the extracellular levels of ions, neurotransmitters, and metabolites, thus maintaining the best conditions for neuronal firing. For example, the brain contains a small amount of glycogen, and this glycogen is found mainly in astrocytes, and is particularly enriched in the hippocampus [50]. This observation is relevant when we consider the role of hippocampus in memory processes [51][52][53].…”

Section: The Role Of Glial Cells In Memorymentioning

confidence: 96%

Cell-to-Cell Communication in Learning and Memory: From Neuro- and Glio-Transmission to Information Exchange Mediated by Extracellular Vesicles

Schiera

Liegro

2019

IJMS

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Most aspects of nervous system development and function rely on the continuous crosstalk between neurons and the variegated universe of non-neuronal cells surrounding them. The most extraordinary property of this cellular community is its ability to undergo adaptive modifications in response to environmental cues originating from inside or outside the body. Such ability, known as neuronal plasticity, allows long-lasting modifications of the strength, composition and efficacy of the connections between neurons, which constitutes the biochemical base for learning and memory. Nerve cells communicate with each other through both wiring (synaptic) and volume transmission of signals. It is by now clear that glial cells, and in particular astrocytes, also play critical roles in both modes by releasing different kinds of molecules (e.g., D-serine secreted by astrocytes). On the other hand, neurons produce factors that can regulate the activity of glial cells, including their ability to release regulatory molecules. In the last fifteen years it has been demonstrated that both neurons and glial cells release extracellular vesicles (EVs) of different kinds, both in physiologic and pathological conditions. Here we discuss the possible involvement of EVs in the events underlying learning and memory, in both physiologic and pathological conditions.

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Glycogen distribution in mouse hippocampus

Cited by 22 publications

References 98 publications

Distinct temporal integration of noradrenaline signaling by astrocytic second messengers during vigilance

Distinct temporal integration of noradrenaline signaling by astrocytic second messengers during vigilance

Neuromodulation of Glial Function During Neurodegeneration

Cell-to-Cell Communication in Learning and Memory: From Neuro- and Glio-Transmission to Information Exchange Mediated by Extracellular Vesicles

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