Glycogen metabolism of normal and leukemic leukocytes

VanderWende, Christina; Miller, Warren L.; Glass, Susan

doi:10.1016/0024-3205(64)90063-3

Cited by 9 publications

(2 citation statements)

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“…The 39 per cent reduction from normal of the mean amount of PASMa in CML-neutrophils thus corresponds well with previous findings that the chemically-determined glycogen content is reduced by about 25-50 per cent in these cells (Valentine 1953, Luganova et ul. 1963, Van der Wende 1964. There is similar agreement between the elevated amount of PASMa in polycythaemia Vera and previous biochemical estimates of glycogen in these cells (Wagner 1947, Valentine 1953, Luganova et ul.…”

Section: Discussionsupporting

confidence: 87%

The Periodic Acid‐Schiff Reaction in Neutrophil Leukocytes in Chronic Myeloproliferative Diseases A microspectrophotometric study

Gahrton

1966

Scandinavian Journal of Haematology

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Microspectrophotometric quantification of the PAS reaction has been carried out in about 4500 individual mature neutrophil leukocytes from 20 normal persons, and from 15 patients with chronic myelocytic leukaemia (CML), 18 patients with myeloid metaplasia, and 17 patients with polycythaemia vera (PV). The reaction is considered to be a quantitative measure of the amount of PAS reactive material (PASMa) in neutrophils, most of it probably glycogen. Neutro‐phils from CML had a mean amount of PASMa that was 39 per cent below normal, the frequency distribution of PASMa per cell being approximately normal in individual cases. Neutrophils from myeloid metaplasia usually had elevated mean amounts of PASMa and considerably elevated variance between cells within subjects. Neutrophils from PV had a mean amount of PASMa that was 33 per cent above normal, with a highly augmented variance between cells within subjects. There was no correlation between the number of nuclear lobes and the amount of PASMa per cell in any diagnostic group. The quantified PAS reaction is considered to be of diagnostic importance for the differentiation of CML and myeloid metaplasia.

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Section: Discussionsupporting

confidence: 87%

The Periodic Acid‐Schiff Reaction in Neutrophil Leukocytes in Chronic Myeloproliferative Diseases A microspectrophotometric study

Gahrton

1966

Scandinavian Journal of Haematology

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“…Parkinsonism may be associated with decreased catecholamine and increased 5hydroxytryptamine levels (Orzeck & Barbeau, 1970), while serum caeruloplasmin is elevated in the disease and has been suggested as a systemic basis for its aetiology (Barbeau, 1969). Caeruloplasmin-like activity has been detected in the brain (VanderWende, 1964;Marsden, 1965) and may be localized in those brain areas, such as the caudate nucleus, where dopamine levels are particularly high and which undergo degeneration in parkinsonism.…”

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confidence: 99%