Glycopeptide-functionalized gold nanoparticles for antibody induction against the tumor associated mucin-1 glycoprotein

Cai, Hui; Degliangeli, Federica; Palitzsch, Björn; Gerlitzki, Bastian; Kunz, Horst; Schmitt, Edgar; Fiammengo, Roberto; Westerlind, Ulrika

doi:10.1016/j.bmc.2016.01.044

Cited by 49 publications

(40 citation statements)

References 31 publications

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“…192–198 Besides DNA, polysaccharides, peptides and glycopeptides are used as vectors in such vaccines. 53,199–205 Moreover, whereas gold was earlier used only as a carrier, Zhao et al 206 noted: “Although the mechanism behind this is not well understood, it appears that gold cartridges might enhance immune responses in vivo ”.…”

Section: Production Of Antibodies By Using Gold Nanoparticlesmentioning

confidence: 99%

Immunological properties of gold nanoparticles

2017

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Section: Production Of Antibodies By Using Gold Nanoparticlesmentioning

confidence: 99%

Immunological properties of gold nanoparticles

2017

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“…[192][193][194][195][196][197][198] Besides DNA, polysaccharides, peptides and glycopeptides are used as vectors in such vaccines. 53,[199][200][201][202][203][204][205] Moreover, whereas gold was earlier used only as a carrier, Zhao et al 206 noted: "Although the mechanism behind this is not well understood, it appears that gold cartridges might enhance immune responses in vivo".…”

Section: Production Of Antibodies By Using Gold Nanoparticlesmentioning

confidence: 99%

Immunological Properties of Gold Nanoparticles

Дыкман¹,

Khlebtsov²

2017

Gold Nanoparticles in Biomedical Applications

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In the past decade, gold nanoparticles have attracted strong interest from the nanobiotechnological community owing to the significant progress made in robust and easy-to-make synthesis technologies, in surface functionalization, and in promising biomedical applications. These include bioimaging, gene diagnostics, analytical sensing, photothermal treatment of tumors, and targeted delivery of various biomolecular and chemical cargos. For the last-named application, gold nanoparticles should be properly fabricated to deliver the cargo into the targeted cells through effective endocytosis. In this review, we discuss recent progress in understanding the selective penetration of gold nanoparticles into immune cells. The interaction of gold nanoparticles with immune cell receptors is discussed. As distinct from other published reviews, we present a summary of the immunological properties of gold nanoparticles. This review also summarizes what is known about the application of gold nanoparticles as an antigen carrier and adjuvant in immunization for the preparation of antibodies in vivo. For each of the above topics, the basic principles, recent advances, and current challenges are discussed. Thus, this review presents a detailed analysis of data on interaction of gold nanoparticles with immune cells.Emphasis is placed on the systematization of data over production of antibodies by using gold nanoparticles and adjuvant properties of gold nanoparticles. Specifically, we start our discussion with current data on interaction of various gold nanoparticles with immune cells. The next section describes existing technologies to improve production of antibodies in vivo by using gold nanoparticles conjugated with specific ligands. Finally, we describe what is known about adjuvant properties of bare gold or functionalized nanoparticles. In the Conclusion section, we present a short summary of reported data and some challenges and perspectives.

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“…Researchers have also incorporated multiple different components, including MUC1 peptides, tumor-associated carbohydrates, immunostimulating T cell peptide epitopes, and adjuvants, to make multifunctional vaccines. In more recent studies, MUC1 glycopeptides were linked to T cell peptide epitopes and either coated onto gold nanoparticles or incorporated into adjuvant-containing nanogels [73,74]. The antisera from the mice immunized with these nanoformulations showed significant increase in antibody titers and could recognize cancer cell lines ex vivo .…”

Section: Membrane-derived Molecules and Subunitsmentioning

confidence: 99%

Cell membrane-derived nanomaterials for biomedical applications

et al. 2017

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The continued evolution of biomedical nanotechnology has enabled clinicians to better detect, prevent, manage, and treat human disease. In order to further push the limits of nanoparticle performance and functionality, there has recently been a paradigm shift towards biomimetic design strategies. By taking inspiration from nature, the goal is to create next-generation nanoparticle platforms that can more effectively navigate and interact with the incredibly complex biological systems that exist within the body. Of great interest are cellular membranes, which play essential roles in biointerfacing, self-identification, signal transduction, and compartmentalization. In this review, we explore the major ways in which researchers have directly leveraged cell membrane-derived biomaterials for the fabrication of novel nanotherapeutics and nanodiagnostics. Such emerging technologies have the potential to significantly advance the field of nanomedicine, helping to improve upon traditional modalities while also enabling novel applications.

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Glycopeptide-functionalized gold nanoparticles for antibody induction against the tumor associated mucin-1 glycoprotein

Cited by 49 publications

References 31 publications

Immunological properties of gold nanoparticles

Immunological properties of gold nanoparticles

Immunological Properties of Gold Nanoparticles

Cell membrane-derived nanomaterials for biomedical applications

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