New styrene derivatives having D,L-xylaric and L-tartaric moieties, N-p-vinylbenzyl-D,L-xylaramic and N-p-vinylbenzyl-Ltartaramic acids (VB-D,L-XylarH 10 and VB-L-TartaH 11), were synthesized by the ring-opening reaction of 2,3,4-tri-Oacetyl-meso-xylaric anhydride and 2,3-di-O-acetyl-L-tartaric anhydride with p-vinylbenzylamine, respectively, and their subsequent hydrolysis under basic condition. The glycomonomers were copolymerized with acrylamide (AAm) to give novel polymers having xylaric and tartaric moieties in the pendants (P(VB-D,L-XylarH-co-AAm) 12 and P(VB-L-TartaH-co-AAm) 13) respectively. The inhibition abilities of the resulting glycopolymers on the -glucuronidase activity were found to be much higher than not only that of the corresponding saccharic acids but also that of the glycomonomers, especially at the lower concentration of saccharic unit by the spectrophotometry. However, the inhibition values were lower than those of the glycopolymers bearing D-glucaric pendant, P(VB-6-D-GlucaH-co-AAm) (5) and P(VB-1-D-GlucaH-co-AAm) (6), reported in our previous work. The Lineweaver-Burk plot suggested that the glycopolymer 13 and the corresponding monomer 11 inhibit the -glucuronidase activity noncompetitively, whereas the inhibition behavior of glycopolymer 12 and monomer 10 is more complicated, probably a mix-type of uncompetitive and noncompetitive ones. These are in contrast to the competitive inhibition in the presence of the glycopolymer 5 and its monomer 1.