1999
DOI: 10.1002/(sici)1099-0518(19990201)37:3<303::aid-pola7>3.0.co;2-4
|View full text |Cite
|
Sign up to set email alerts
|

Glycopolymeric inhibitors of ?-glucuronidase I. Synthesis and polymerization of styrene derivatives having pendantD-glucaric moieties

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1

Citation Types

2
27
0

Year Published

2002
2002
2018
2018

Publication Types

Select...
6

Relationship

2
4

Authors

Journals

citations
Cited by 21 publications
(29 citation statements)
references
References 26 publications
2
27
0
Order By: Relevance
“…In our previous work, [5][6][7] The water soluble random copolymers of 1 and 2 with acrylamide, poly(N-p-vinylbenzyl-6-D-glucaramic acid-coacrylamide) (P(VB-6-D-GlucaH-co-AAm), 5), poly(N-p-vinylbenzyl-1-D-glucaramic acid-co-acrylamide) (P(VB-1-DGlucaH-co-AAm), 6), respectively, were found to suppress the hydrolysis of a model compound for the xenobiotics--Dglucuronide conjugates, p-nitrophenyl -D-glucuronide (9). However, the copolymers, poly(N-p-vinylbenzyl-6-L-gulonamide-co-acrylamide) (P(VB-6-D-Glco-co-AAm), 7), and poly-(N-p-vinylbenzyl-1-D-gluconamide-co-acrylamide) (P(VB-1-D-Glco-co-AAm), 8), respectively, scarcely inhibited the hydrolysis (Scheme 9).…”
mentioning
confidence: 93%
See 3 more Smart Citations
“…In our previous work, [5][6][7] The water soluble random copolymers of 1 and 2 with acrylamide, poly(N-p-vinylbenzyl-6-D-glucaramic acid-coacrylamide) (P(VB-6-D-GlucaH-co-AAm), 5), poly(N-p-vinylbenzyl-1-D-glucaramic acid-co-acrylamide) (P(VB-1-DGlucaH-co-AAm), 6), respectively, were found to suppress the hydrolysis of a model compound for the xenobiotics--Dglucuronide conjugates, p-nitrophenyl -D-glucuronide (9). However, the copolymers, poly(N-p-vinylbenzyl-6-L-gulonamide-co-acrylamide) (P(VB-6-D-Glco-co-AAm), 7), and poly-(N-p-vinylbenzyl-1-D-gluconamide-co-acrylamide) (P(VB-1-D-Glco-co-AAm), 8), respectively, scarcely inhibited the hydrolysis (Scheme 9).…”
mentioning
confidence: 93%
“…Therefore the inhibition of the -glucuronidase activity would be effective for exhausting of the xenobiotics from the body. [2][3][4][5][6][7] D-Glucaric acid and their lactone derivatives are known to be efficient inhibitors for -glucuronidase. [8][9][10][11][12][13][14][15][16] However, even if these saccharic derivatives were administered orally, they would be absorbed before reaching the small intestine.…”
mentioning
confidence: 99%
See 2 more Smart Citations
“…Currently, well‐defined glycopolymers with different architectures (e.g. linear, star‐shaped, and dendritic) have been intensively investigated by many research groups 10–14, 19–31. As an extension, Cloninger et al .…”
Section: Introductionmentioning
confidence: 99%