Glycoprotein Based Phylogenetic Analysis of Rabies Virus Isolates

Tomar, Neha R.; Kumar, Rajiv; Kumar, Anil

doi:10.20546/ijcmas.2017.607.208

Cited by 1 publication

(3 citation statements)

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“…G protein antigenic sites (Tomar et al., 2017) were relatively conserved with a few exceptions. Isolates SA194858, SA212203, and SA252888 had multiple changes in antigenic site III (residues 330–338).…”

Section: Resultsmentioning

confidence: 99%

“…As it represents the major contributor to RABV pathogenicity (Faber et al., 2005), the glycoprotein (G) sequences from the new characterized isolates were screened for conservation of amino acid residues of virulence previously described (Dietzschold et al., 1983; Marston et al., 2007; Tomar et al., 2017). A motive was considered as non‐conserved when it presents more than two non‐conservative mutations in more than two RABV isolates.…”

Section: Methodsmentioning

confidence: 99%

“…The N-glycosylation motif NKT was previously described by Marston et al (2007). The ten remaining RABV amino acid motifs were analyzed as described by Tomar et al (2017). Positions with amino acid different on the glycoprotein of Senegalese RABV are highlighted in bold and black for conservative mutations and in bold and black and underlined for non-conservative mutations.…”

Section: Phylodynamics Of Rabv In Senegal and Western Africamentioning

confidence: 99%

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Rabies surveillance in Senegal 2001 to 2015 uncovers first infection of a honey‐badger

Faye

Paola

et al. 2022

Transbounding Emerging Dis

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Despite the establishment of Rabies surveillance in animals and humans since 2008, there is a lack of data on its circulation, dynamic of transmission and real burden in Senegal. To better understand the molecular epidemiology of rabies virus in Senegal, we investigated the genetic diversity of 18 new characterized Senegalese rabies virus sequences collected over 14 years, including a honey-badger-related isolate. Phylogeographic analyses demonstrated that the Senegalese isolates belong to a monophyletic cluster into the Africa-2 clade and supported two RABV introductions in Senegal from West-African neighbour countries, 36-40 years ago. Our study is noteworthy for reporting on the first characterization of an African honey-badger-related rabies virus that did not have the N-glycosylation site NKT at position 338-G of the glycoprotein. The identified amino acid polymorphisms found in the Senegalese rabies virus sequences are worthy of further investigation. Although a strong multidisciplinary stepwise cooperation is important for the successful elimination of Rabies in dog populations in Senegal by 2030, the establishment of surveillance in wildlife could be necessary to avoid future re-introductions into domestic hosts.

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Section: Resultsmentioning

confidence: 99%