Glycoprotein levels and oxidative lung injury in experimental diabetes: effect of oxovanadium(IV) complex based on thiosemicarbazone

Bayrak, Bertan Boran; Tunalı, Sevim; Bal‐Demirci, Tülay; Ülküseven, Bahrı; Yanardağ, Refiye

doi:10.1080/15376516.2021.1941462

Cited by 4 publications

(4 citation statements)

References 88 publications

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“…The CA expressed in capillary endothelia of the lung contributes to the converting process of H + and HCO 3 − dissolved in the serum (several percent of total produced CO 2 ) to CO 2 + H 2 O (H + + HCO 3 − → CO 2 + H 2 O). The activity of CA expressed in capillary endothelia of the lung has been reported to be lower in DM patients than healthy persons [51]. These reports [49][50][51] ] s would decrease associated with elevation of FBS or/and HbA1c due to the low activity of CA under the FBS/HbA1c-elevated condition; (6) the lower activity of CA in persons with high FBS or/and HbA1c might cause acidotic conditions in blood and interstitial fluids, causing the insulin resistance [6][7][8][9][10]19,30,41].…”

Section: Discussionmentioning

confidence: 99%

Possibility of Venous Serum Cl− Concentration ([Cl−]s) as a Marker for Human Metabolic Status: Correlation of [Cl−]s to Age, Fasting Blood Sugar (FBS), and Glycated Hemoglobin (HbA1c)

Marunaka

Yagi

Imagawa

et al. 2021

IJMS

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The HCO3− concentration in venous serum ([HCO3−]s) is a factor commonly used for detecting the body pH and metabolic conditions. To exactly detect [HCO3−]s, the venous CO2 pressure should be kept as it is in the vein. The [HCO3−]s measurement is technically complicated to apply for huge numbers of almost heathy persons taking only basic medical examinations. The summation of [HCO3−]s and the venous serum Cl− concentration ([Cl−]s) is approximately constant; therefore, we studied if [Cl−]s could be a marker detecting metabolic conditions instead of [HCO3−]s. Venous blood was obtained from persons taking basic medical examinations (the number of persons = 107,630). Older persons showed higher values of [Cl−]s, fasting blood sugar (FBS), and glycated hemoglobin (HbA1c) than younger ones. [Cl−]s showed positive correlation to age and negative correlation to FBS and HBA1c. The negative correlation of [Cl−]s to FBS/HbA1c was obvious in persons with high FBS/HbA1c, leading us to an idea that persons with high FBS/HbA1c show high [HCO3−]s, which might be caused by low activity of carbonic anhydrase in the lung observed in persons with diabetes mellitus under acidotic conditions. Taken together, an easily measured serum electrolyte, [Cl−]s, could be a useful marker estimating metabolic conditions.

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Section: Discussionmentioning

confidence: 99%

Possibility of Venous Serum Cl− Concentration ([Cl−]s) as a Marker for Human Metabolic Status: Correlation of [Cl−]s to Age, Fasting Blood Sugar (FBS), and Glycated Hemoglobin (HbA1c)

Marunaka

Yagi

Imagawa

et al. 2021

IJMS

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“…After one week, the serum glucose level was measured using a spectrophotometer set to 505 nm and the glucose oxidase/pyruvate oxidase (GOD-POD) technique. Animals were considered hyperglycemic if their serum glucose levels were greater than 200 mg/dl [18]. Isolated rat heart preparation Sodium pentobarbital (60mg/kg, i.m.)…”

Section: Induction Of Experimental Diabetesmentioning

confidence: 99%

“…The release of nitrite in the coronary drainage was measured by using Griess reagent and spectrophotometric analysis was performed at 550 nm. The nitrite concentration was determined andresults were expressed as micromoles per litre [18].…”

Section: Nitrite Estimationmentioning

confidence: 99%

“…To measure GSH, we mixed 0.5 millilitres of 5,5 dithiobis-2-nitrobenzoic acid (DTNB) with 0.5 millilitres of supernatant, 2.0 millilitres of phosphate buffer (0.3 M, pH 8.4), 0.4 millilitres of double-distilled water, and 0.1 millilitre of supernatant. Following a 10-minute incubation period, the reaction mixture's absorbance was measured at 412 nm [18].…”

Section: Assessment Of Glutathioneperoxidase (Gsh) Activitymentioning

confidence: 99%

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Involvement Of Inula Racemose Hook Extract on Ischemic Preconditioning Mediated Cardioprotection in Diabetes

Tiwari,

Gupta,

Prasad

2023

ijmst

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Objective: Ischemia of the heart is one of the major cause behind diabetes mediate death in peoples. PI3K/Akt phosphorylation is inhibited in IPC-induced infarcts, preventing the opening of the mitochondrial permeability transition pore (MPTP). In diabetics, the beneficial effects are lessened. IPC-mediated cardioprotection in diabetic Wistar rat hearts was observed in this study after pre-treatment with Inula racemosa Hook root extract (IrA). Ischemia reperfusion (I / R) and cycles of IPC were performed on an isolated rat heart mounted on Langendorff's assembly. MPTP is opened by atractyloside (ATR). Method: RP-HPLC and 1H and 13C NMR were used to identify the chemical components. Western blot, oxidative stress, mitochondrial function, integrity, and haemodynamic parameters are all examined in this study. Result: Pretreatment with IrA reduced LDH, CKMB, myocardial infarction size, ventricular fibrillation, and cardiac collagen content, as well as decreased oxidative stress levels and mitochondrial dysfunction in diabetic rat hearts in all groups, according to the data. By blocking the opening of MPTP in diabetic rats, ATR reduced the cardioprotective effect of IrA on IPC. Conclusion: This shows that IPC-mediated cardioprotection can be restored by pre-treatment with IrA, which inhibits the opening of the MPTP in diabetic rats.

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Antioxidant Activity and Protective Effects of an Oxovanadium (IV) Complex on Heart and Aorta Injury of STZ-Diabetic Rats

Ertik,

Tunali,

Acar

et al. 2023

Biol Trace Elem Res

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Glycoprotein levels and oxidative lung injury in experimental diabetes: effect of oxovanadium(IV) complex based on thiosemicarbazone

Cited by 4 publications

References 88 publications

Possibility of Venous Serum Cl− Concentration ([Cl−]s) as a Marker for Human Metabolic Status: Correlation of [Cl−]s to Age, Fasting Blood Sugar (FBS), and Glycated Hemoglobin (HbA1c)

Possibility of Venous Serum Cl− Concentration ([Cl−]s) as a Marker for Human Metabolic Status: Correlation of [Cl−]s to Age, Fasting Blood Sugar (FBS), and Glycated Hemoglobin (HbA1c)

Involvement Of Inula Racemose Hook Extract on Ischemic Preconditioning Mediated Cardioprotection in Diabetes

Antioxidant Activity and Protective Effects of an Oxovanadium (IV) Complex on Heart and Aorta Injury of STZ-Diabetic Rats

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