Glycoproteins from the hamster respiratory tract and their response to vitamin A

Bonanni, F; Levinson, Stanley S.; Wolf, George; Luca, Luigi De

doi:10.1016/0304-4165(73)90091-3

Cited by 63 publications

(10 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These results lend further support to the earlier claims that vitamin A is specifically required in the differentiation of intestinal epithelial cells which are the main target, for admittance of various nutrients to the body (30,31). The present work thus suggests that vitamin A deficiency, which stimulates the absorption of exogenous oxalate through the gut, must be seen as an aggravating factor that increases the prevalence of stone formation in a general population afflicted with a marginal deficiency of this vitamin.…”

Section: Discussionsupporting

confidence: 76%

Effect of vitamin A deficiency on oxalate uptake by rat intestinal brush border membrane vesicles (BBMV) and its contribution towards urolithiasis.

Sharma

Narula

Nath

et al. 1990

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

View full text Add to dashboard Cite

SummaryThe intestinal uptake of [14C]oxalate, [14C] glyoxylate, and [14C] glycolate are studied in brush border membrane vesicles (BBMV) isolated from vitamin A-deficient and pair-fed control rats. The data obtained indicate that oxalate and its precursors are transported across the BBMV by passive diffusion. The intestinal uptake of glyoxylate and glycolate remains unaltered in vitamin A deficiency, while uptake rate of oxalate was significantly increased (p<0.01) in vitamin A-deficient rats as compared to pair-fed controls. In conclusion, the results indicate that vitamin A deficiency leads to hyperabsorption of oxalate through the gut.

show abstract

Section: Discussionsupporting

confidence: 76%

Effect of vitamin A deficiency on oxalate uptake by rat intestinal brush border membrane vesicles (BBMV) and its contribution towards urolithiasis.

Sharma

Narula

Nath

et al. 1990

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

View full text Add to dashboard Cite

show abstract

“…Subsequently, Bonanni et al (10,11) showed that when relatively stable macromolecular products such as glycopeptides were the object for study, such products could be isolated from tracheal epithelial cells that were enzymatically dissociated from the underlying supportive structures by incubation with hyaluronidase. Even smaller quantities of tissue than those used above apparently have been sufficient for studies of gelelectrophoretic analyses of LDH isozymes in the bronchi of rats exposed intratracheally to benzo(a)pyrene (BP).…”

Section: Methods For Biochemical Study Of Tracheobronchial Epitheliummentioning

confidence: 99%

“…On the macromolecular level, it was hypothesized (9,24) (7,10,11,76,77) as the result of a decreased capacity to manufacture mucus glycoproteins with specific sugar moieties. Further support for a role for vitamin A in glucoprotein synthesis came from work by Clark and Marchok (76,77 (35,36,(38)(39)(40)78) as an assay for retinoid potency.…”

Section: Rna Metabolism and Inhibitors Of Rna Synthesismentioning

confidence: 99%

Biochemical Studies of the Tracheobronchial Epithelium

Mass¹,

Kaufman²

1984

Environmental Health Perspectives

View full text Add to dashboard Cite

Tracheobronchial epithelium has been a focus of intense investigation in the field of chemical carcinogenesis. We have reviewed some biochemical investigations that have evolved through linkage with carcinogenesis research. These areas of investigation have included kinetics of carcinogen metabolism, identification of carcinogen metabolites, levels of carcinogen binding to DNA, and analysis of carcinogen-DNA adducts. Such studies appear to have provided a reasonable explanation for the susceptibilities of the respiratory tracts of rats and hamsters to carcinogenesis by benzo(a)pyrene. Coinciding with the attempts to understand the initiation of carcinogenesis in the respiratory tract has also been a major thrust aimed at effecting its prevention both in humans and in animal models for human bronchogenic carcinoma. These studies have concerned the effects of derivatives of vitamin A (retinoids) and their influence on normal cell biology and biochemistry of this tissue. Recent investigations have included the effects of retinoid deficiency on the synthesis of RNA and the identification of RNA species associated with this biological state, and also have included the effects of retinoids on the synthesis of mucus-related glycoproteins.Tracheal organ cultures from retinoid-deficient hamsters have been used successfully to indicate the potency of synthetic retinoids by monitoring the reversal of squamous metaplasia. Techniques applied to this tissue have also served to elucidate features of the metabolism of retinoic acid using high pressure liquid chromatography. In brief, formidable strides have been made in biochemistry specific to this important target tissue, despite the inability to acquire tracheobronchial epithelium in large quantities.

show abstract

“…A great deal of experimental evidence has established a role for vitamin A in glycoprotein synthesis. Thus, vitamin A deficiency results in diminished synthesis of glycoproteins in intestine (De Luca, Schumacher & Wolf 1970), cornea (Kim & Wolf 1974), trachea (Bonanni et al 1973), andliver (De Luca Silverman-Iones &Barr 1975). The connective tissue of hypervitaminotic A animals liberates lysosomal enzymes .…”

mentioning

confidence: 99%

Variation in sialic acid concentration in gingival tissue from rats receiving excess vitamin A

Paiva

Nicolau

1982

J of Periodontal Research

View full text Add to dashboard Cite

The effect of 1 to 5 doses of 15,000 I.U. of vitamin A on N‐acetyl neuraminic acid (NANA) concentration in gingival tissue from rats was studied. Increased sialic acid concentration was observed in those animals receiving up to 4 doses of the vitamin, while a decreased concentration was found in the 5 doses group. Also examined was the interrelationship between vitamin A‐cortisol and vitamin A‐ascorbic acid. The profile of NANA variation in the groups receiving vitamin A plus ascorbic acid was similar to that of animals receiving only ascorbic acid. The data obtained for the groups receiving both vitamin A and cortisol, did not differ from that obtained for the groups receiving only vitamin A.

show abstract

Glycoproteins from the hamster respiratory tract and their response to vitamin A

Cited by 63 publications

References 11 publications

Effect of vitamin A deficiency on oxalate uptake by rat intestinal brush border membrane vesicles (BBMV) and its contribution towards urolithiasis.

Effect of vitamin A deficiency on oxalate uptake by rat intestinal brush border membrane vesicles (BBMV) and its contribution towards urolithiasis.

Biochemical Studies of the Tracheobronchial Epithelium

Variation in sialic acid concentration in gingival tissue from rats receiving excess vitamin A

Contact Info

Product

Resources

About