No abstract

No abstract

Thirsty rats, trained to press a lever for distilled water or .15 M solutions of various salts, were tested when neither thirsty nor rewarded. Rats receiving sodium salts (chloride, phosphate, or acetate) during training but sodium depleted during testing pressed 2-3 times more during testing than (a) rats trained with distilled water, calcium chloride, or potassium chloride solutions and were sodium depleted during testing, (b) rats trained with water or with sodium chloride solution but not sodium depleted during testing, or (c) rats trained with sodium chloride solutions and sodium depleted but repleted with sodium prior to testing.

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The effect of DOC on sodium chloride (saline) intake was studied in intact and adrenalectomized rats under "two-bottle" self-selection conditions. It was found that in adrenalectomized rats low doses of DOC produced a decrease in saline intake (restoration of sodium-retaining ability), whereas high doses produced an increase in saline intake (stimulation of sodium appetite). At high doses, however, intact rats consumed more saline and manifested a greater preference for it than did similarly treated adrenalectomized rats. Treatment with corticosterone increased both absolute saline intake and saline preference of DOC-treated adrenalectomized rats.